Molecules and Cells

Cited by CrossRef (156)

  1. Ju-Xian Song, Jia Liu, Yimin Jiang, Zi-Ying Wang, Min Li. Transcription factor EB: an emerging drug target for neurodegenerative disorders. Drug Discovery Today 2021;26:164
    https://doi.org/10.1016/j.drudis.2020.10.013
  2. Vichitra Chandrasekaran, Tousif Ahmed Hediyal, Nikhilesh Anand, Pavan Heggadadevanakote Kendaganna, Vasavi Rakesh Gorantla, Arehally M. Mahalakshmi, Ruchika Kaul Ghanekar, Jian Yang, Meena Kishore Sakharkar, Saravana Babu Chidambaram. Polyphenols, Autophagy and Neurodegenerative Diseases: A Review. Biomolecules 2023;13:1196
    https://doi.org/10.3390/biom13081196
  3. Khaled S. Abd-Elrahman, Alison Hamilton, Maryam Vasefi, Stephen S. G. Ferguson. Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models. Mol Brain 2018;11
    https://doi.org/10.1186/s13041-018-0364-9
  4. Chang-Long He, Yong Tang, Xue Chen, Tao Long, Yan-Ni He, Jing Wei, Jian-Ming Wu, Cai Lan, Lu Yu, Fei-Hong Huang, Cong-Wei Gu, Jian Liu, Chong-Lin Yu, Vincent Kam-Wai Wong, Betty Yuen-Kwan Law, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou. Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases. Phytomedicine 2023;109:154548
    https://doi.org/10.1016/j.phymed.2022.154548
  5. Kaja Urbańska, Arkadiusz Orzechowski. The Secrets of Alternative Autophagy. Cells 2021;10:3241
    https://doi.org/10.3390/cells10113241
  6. Sataree Khuansuwan, Lisa M. Barnhill, Sizhu Cheng, Jeff M. Bronstein. A novel transgenic zebrafish line allows for in vivo quantification of autophagic activity in neurons. Autophagy 2019;15:1322
    https://doi.org/10.1080/15548627.2019.1580511
  7. Angela Dixon, Myoung Sup Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, Paloma B. Liton. Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontaneous glaucoma mouse models. Cell Death Dis 2023;14
    https://doi.org/10.1038/s41419-023-06086-3
  8. Pol Andrés-Benito, Ignacio Íñigo-Marco, Marta Brullas, Margarita Carmona, José Antonio del Rio, Joaquín Fernández-Irigoyen, Enrique Santamaría, Mónica Povedano, Isidro Ferrer. Proteostatic modulation in brain aging without associated Alzheimer’s disease-and age-related neuropathological changes. Aging 2023;15:3295
    https://doi.org/10.18632/aging.204698
  9. Firyal Ramzan, Fatima Abrar, Gyana Gourab Mishra, Lucia Meng Qi Liao, Dale D. O. Martin. Lost in traffic: consequences of altered palmitoylation in neurodegeneration. Front. Physiol. 2023;14
    https://doi.org/10.3389/fphys.2023.1166125
  10. Janani Manochkumar, C. George Priya Doss, Hesham R. El-Seedi, Thomas Efferth, Siva Ramamoorthy. The neuroprotective potential of carotenoids in vitro and in vivo. Phytomedicine 2021;91:153676
    https://doi.org/10.1016/j.phymed.2021.153676
  11. Ting Sun. Long noncoding RNAs act as regulators of autophagy in cancer. Pharmacological Research 2018;129:151
    https://doi.org/10.1016/j.phrs.2017.11.009
  12. Christina G. Towers, Andrew Thorburn. Therapeutic Targeting of Autophagy. EBioMedicine 2016;14:15
    https://doi.org/10.1016/j.ebiom.2016.10.034
  13. A. B. Pupyshev, T. A. Korolenko, M. A. Tikhonova. A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy. Neurosci Behav Physi 2017;47:1109
    https://doi.org/10.1007/s11055-017-0519-7
  14. A. Raquel Esteves, Filipa Filipe, João D. Magalhães, Diana F. Silva, Sandra M. Cardoso. The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease. Mol Neurobiol 2019;56:5654
    https://doi.org/10.1007/s12035-019-1483-8
  15. Leyan Feng, Heping Wang, Xue Xue. Recent Progress of Nanomedicine in the Treatment of Central Nervous System Diseases. Advanced Therapeutics 2020;3
    https://doi.org/10.1002/adtp.201900159
  16. Fouzi Magraoui, Christina Reidick, Hemut Meyer, Harald Platta. Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease. Cells 2015;4:596
    https://doi.org/10.3390/cells4040596
  17. Dunxin Shen, Kenneth Hensley, Travis T. Denton. An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues. Analytical Biochemistry 2020;591:113543
    https://doi.org/10.1016/j.ab.2019.113543
  18. Yann Wan Yap, Roxana M. Llanos, Sharon La Fontaine, Michael A. Cater, Philip M. Beart, Nam Sang Cheung. Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy–Lysosomal Pathway. Neurochem Res 2016;41:554
    https://doi.org/10.1007/s11064-015-1666-2
  19. Dexiang Liu, Zunji Ke, Jia Luo. Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy. Mol Neurobiol 2017;54:5440
    https://doi.org/10.1007/s12035-016-0079-9
  20. Ziyan Zhang, Jingqi Yan, Aaron B. Bowman, Miles R. Bryan, Rajat Singh, Michael Aschner. Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes. Autophagy 2020;16:1506
    https://doi.org/10.1080/15548627.2019.1688488
  21. Shohreh Majd, John H. Power, Hugh J. M. Grantham. Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways. BMC Neurosci 2015;16
    https://doi.org/10.1186/s12868-015-0211-1
  22. Milad Moloudizargari, Mohammad Hossein Asghari, Emad Ghobadi, Marjan Fallah, Shima Rasouli, Mohammad Abdollahi. Autophagy, its mechanisms and regulation: Implications in neurodegenerative diseases. Ageing Research Reviews 2017;40:64
    https://doi.org/10.1016/j.arr.2017.09.005
  23. Hee-Young Sohn, Seong-Ik Kim, Jee-Yun Park, Sung-Hye Park, Young Ho Koh, Joon Kim, Chulman Jo. ApoE4 attenuates autophagy via FoxO3a repression in the brain. Sci Rep 2021;11
    https://doi.org/10.1038/s41598-021-97117-6
  24. Zhong-Hao Zhang, Qiu-Yan Wu, Chen Chen, Rui Zheng, Yao Chen, Qiong Liu, Jia-Zuan Ni, Guo-Li Song. Selenomethionine Attenuates the Amyloid-β Level by Both Inhibiting Amyloid-β Production and Modulating Autophagy in Neuron-2a/AβPPswe Cells. JAD 2017;59:591
    https://doi.org/10.3233/JAD-170216
  25. Khaled S. Abd-Elrahman, Alison Hamilton, Awatif Albaker, Stephen S. G. Ferguson. mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent. ACS Pharmacol. Transl. Sci. 2020;3:334
    https://doi.org/10.1021/acsptsci.0c00013
  26. Xiaoming Zhang, Youfa Zhou, Mingmin Xu, Gang Chen, David Blum. Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats. PLoS ONE 2016;11:e0153505
    https://doi.org/10.1371/journal.pone.0153505
  27. Ling Zheng, Xin-Yi Li, Feng-Zhen Huang, Xia-Tian Zhang, He-Bin Tang, Yu-Sang Li, Wei Kevin Zhang, Xiao-Jun Li, Gui-Hua Tian. Effect of electroacupuncture on relieving central post-stroke pain by inhibiting autophagy in the hippocampus. Brain Research 2020;1733:146680
    https://doi.org/10.1016/j.brainres.2020.146680
  28. Jee-Yun Park, Hee-Young Sohn, Young Ho Koh, Chulman Jo. A splicing variant of TFEB negatively regulates the TFEB-autophagy pathway. Sci Rep 2021;11
    https://doi.org/10.1038/s41598-021-00613-y
  29. Rudranil De, Somnath Mazumder, Uday Bandyopadhyay. Mediators of mitophagy that regulate mitochondrial quality control play crucial role in diverse pathophysiology. Cell Biol Toxicol 2021;37:333
    https://doi.org/10.1007/s10565-020-09561-1
  30. Dalinda Isabel Sánchez-Vidaña, Jingjing Li, Samuel Abokyi, Jackie Ngai-Man Chan, Shirley Pui-Ching Ngai, Benson Wui-Man Lau. In vitro methods in autophagy research: Applications in neurodegenerative diseases and mood disorders. Front. Mol. Neurosci. 2023;16
    https://doi.org/10.3389/fnmol.2023.1168948
  31. Nicolas Ruffini, Susanne Klingenberg, Raoul Heese, Susann Schweiger, Susanne Gerber. The Big Picture of Neurodegeneration: A Meta Study to Extract the Essential Evidence on Neurodegenerative Diseases in a Network-Based Approach. Front. Aging Neurosci. 2022;14
    https://doi.org/10.3389/fnagi.2022.866886
  32. Hongjun Xie, Jie Wu. Silica nanoparticles induce alpha-synuclein induction and aggregation in PC12-cells. Chemico-Biological Interactions 2016;258:197
    https://doi.org/10.1016/j.cbi.2016.09.006
  33. Rachel E. Lackie, Andrzej Maciejewski, Valeriy G. Ostapchenko, Jose Marques-Lopes, Wing-Yiu Choy, Martin L. Duennwald, Vania F. Prado, Marco A. M. Prado. The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases. Front. Neurosci. 2017;11
    https://doi.org/10.3389/fnins.2017.00254
  34. Liang Chen, Hongyuan Fu, Tongyu Lu, Jianye Cai, Wei Liu, Jia Yao, Jinliang Liang, Hui Zhao, Jiebin Zhang, Jun Zheng, Yingcai Zhang, Yang Yang. An Integrated Nomogram Combining Clinical Factors and Microtubule-Associated Protein 1 Light Chain 3B Expression to Predict Postoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma. Cancer Res Treat 2020;52:469
    https://doi.org/10.4143/crt.2019.423
  35. Xiaoxian Xie, Ruonan Shu, Chunan Yu, Zhengwei Fu, Zezhi Li. Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases. Aging and disease 2022;13:157
    https://doi.org/10.14336/AD.2021.0729
  36. Wei Liu, Shi-ou Zhu, Yu-lin Guo, Long-fang Tu, Yong-qi Zhen, Rong-yan Zhao, Liang Ou-Yang, Hiroshi Kurihara, Rong-Rong He, Bo Liu. BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy. Acta Pharmacol Sin 2023;44:524
    https://doi.org/10.1038/s41401-022-00972-w
  37. Rob U. Onyenwoke, Jay E. Brenman. Lysosomal Storage Diseases-Regulating Neurodegeneration. J Exp Neurosci 2015;9s2:JEN.S25475
    https://doi.org/10.4137/JEN.S25475
  38. Anthony R. Anzell, Rita Maizy, Karin Przyklenk, Thomas H. Sanderson. Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury. Mol Neurobiol 2018;55:2547
    https://doi.org/10.1007/s12035-017-0503-9
  39. Xiaohua Li, Shikun He, Binyun Ma. Autophagy and autophagy-related proteins in cancer. Mol Cancer 2020;19
    https://doi.org/10.1186/s12943-020-1138-4
  40. Rashad Hussain, Hira Zubair, Sarah Pursell, Muhammad Shahab. Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches. Brain Sciences 2018;8:177
    https://doi.org/10.3390/brainsci8090177
  41. Zhongkang Zhu, Yuxi Liu, Xinyun Li, Lin Zhang, Huihui Liu, Yong Cui, Yanjie Wang, Danyu Zhao. GPNMB mitigates Alzheimer’s disease and enhances autophagy via suppressing the mTOR signal. Neuroscience Letters 2022;767:136300
    https://doi.org/10.1016/j.neulet.2021.136300
  42. Ivan Dikic, Zvulun Elazar. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol 2018;19:349
    https://doi.org/10.1038/s41580-018-0003-4
  43. Hsiao-Chien Ting, Chia-Yu Chang, Kang-Yun Lu, Hong-Meng Chuang, Sheng-Feng Tsai, Mao-Hsuan Huang, Ching-Ann Liu, Shinn-Zong Lin, Horng-Jyh Harn. Targeting Cellular Stress Mechanisms and Metabolic Homeostasis by Chinese Herbal Drugs for Neuroprotection. Molecules 2018;23:259
    https://doi.org/10.3390/molecules23020259
  44. Yasmin Fardghassemi, Claudia Maios, J. Alex Parker. Small Molecule Rescue of ATXN3 Toxicity in C. elegans via TFEB/HLH-30. Neurotherapeutics 2021;18:1151
    https://doi.org/10.1007/s13311-020-00993-5
  45. Prashant Koshal, Ilenia Matera, Vittorio Abruzzese, Angela Ostuni, Faustino Bisaccia. The Crosstalk between HepG2 and HMC-III Cells: In Vitro Modulation of Gene Expression with Conditioned Media. IJMS 2022;23:14443
    https://doi.org/10.3390/ijms232214443
  46. Ruth Ruiz Esparza-Garrido, María Eugenia Torres-Márquez, Rubí Viedma-Rodríguez, Ana Claudia Velázquez-Wong, Fabio Salamanca-Gómez, Haydeé Rosas-Vargas, Miguel Ángel Velázquez-Flores. Breast cancer cell line MDA-MB-231 miRNA profile expression after BIK interference: BIK involvement in autophagy. Tumor Biol. 2016;37:6749
    https://doi.org/10.1007/s13277-015-4494-8
  47. Daniela Liśkiewicz, Arkadiusz Liśkiewicz, Mateusz Grabowski, Marta Maria Nowacka-Chmielewska, Konstancja Jabłońska, Anna Wojakowska, Łukasz Marczak, Jarosław J. Barski, Andrzej Małecki. Upregulation of hepatic autophagy under nutritional ketosis. The Journal of Nutritional Biochemistry 2021;93:108620
    https://doi.org/10.1016/j.jnutbio.2021.108620
  48. Hui Liu, Hongyan Qiu, Qian Xiao, Weidong Le. Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer’s Disease through AMPK-mTOR Signaling in the APPSwe/PS1dE9 Mouse Model. JAD 2015;48:1019
    https://doi.org/10.3233/JAD-150303
  49. Xiaoying Li, Feng Jin, Yang Li. A novel autophagy‐related lncRNA prognostic risk model for breast cancer. J Cellular Molecular Medi 2021;25:4
    https://doi.org/10.1111/jcmm.15980
  50. Ramu Venkatesan, Yong Un Park, Eunhee Ji, Eui-Ju Yeo, Sun Yeou Kim. Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer’s disease. Cell Death Discov. 2017;3
    https://doi.org/10.1038/cddiscovery.2017.7
  51. Rohan S. Kulkarni, Manmohan Bajaj, Vaijayanti P. Kale. Autophagy in Health and Disease. 2017.
    https://doi.org/10.1007/978-3-319-98146-8_3
  52. Karolina Pircs, Rebecca Petri, Johan Jakobsson, Bryan W. Luikart. Crosstalk between MicroRNAs and Autophagy in Adult Neurogenesis: Implications for Neurodegenerative Disorders. BPL 2018;3:195
    https://doi.org/10.3233/BPL-180066
  53. Daniela Liśkiewicz, Arkadiusz Liśkiewicz, Marta M. Nowacka-Chmielewska, Mateusz Grabowski, Natalia Pondel, Konstancja Grabowska, Sebastian Student, Jaroslaw J. Barski, Andrzej Małecki. Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet. Front. Cell. Neurosci. 2021;15
    https://doi.org/10.3389/fncel.2021.733607
  54. Zhigang Liang, Zhuli Liu, Xuwen Sun, Manli Tao, Xiao Xiao, Guoping Yu, Xiaomin Wang. The Effect of Fucoidan on Cellular Oxidative Stress and the CatD-Bax Signaling Axis in MN9D Cells Damaged by 1-Methyl-4-Phenypyridinium. Front. Aging Neurosci. 2019;10
    https://doi.org/10.3389/fnagi.2018.00429
  55. Rohan Gupta, Rashmi K. Ambasta, Pravir Kumar. Autophagy and apoptosis cascade: which is more prominent in neuronal death?. Cell. Mol. Life Sci. 2021;78:8001
    https://doi.org/10.1007/s00018-021-04004-4
  56. Sheng Dai, Andrés E. Dulcey, Xin Hu, Christopher A. Wassif, Forbes D. Porter, Christopher P. Austin, Daniel S. Ory, Juan Marugan, Wei Zheng. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy 2017;13:1435
    https://doi.org/10.1080/15548627.2017.1329081
  57. Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E Jönsson, Pia A Johansson, Romina Vuono, Shaline V Fazal, Thomas Stoker, Bob A Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S Hébert, György Marko-Varga, Malin Parmar, Roger A Barker, Johan Jakobsson. Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease. 2022;145:3035
    https://doi.org/10.1093/brain/awab473
  58. Giuseppe Grasso, Anna Maria Santoro, Valeria Lanza, Diego Sbardella, Grazia Raffaella Tundo, Chiara Ciaccio, Stefano Marini, Massimo Coletta, Danilo Milardi. The double faced role of copper in Aβ homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration. Coordination Chemistry Reviews 2017;347:1
    https://doi.org/10.1016/j.ccr.2017.06.004
  59. Di Chen, Mengmeng Wang, Yushuang Xu, Xin Jiang, Lina Xiong, Li Zhang, Honglu Yu, Zhifan Xiong. A Novel Autophagy-Related lncRNA Prognostic Signature Associated with Immune Microenvironment and Survival Outcomes of Gastric Cancer Patients. IJGM 2021;Volume 14:6935
    https://doi.org/10.2147/IJGM.S331959
  60. Seema Singh, Annadurai Thangaraj, Ernest T. Chivero, Ming-Lei Guo, Palsamy Periyasamy, Shilpa Buch. Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia. J Neuroimmune Pharmacol 2023
    https://doi.org/10.1007/s11481-023-10063-0
  61. Wei Li, Jieru Lin, Zhichen Shi, Jiren Wen, Yuyin Li, Zhenxing Liu, Aipo Diao. Clomiphene citrate induces nuclear translocation of the TFEB transcription factor and triggers apoptosis by enhancing lysosomal membrane permeabilization. Biochemical Pharmacology 2019;162:191
    https://doi.org/10.1016/j.bcp.2018.11.016
  62. E. Yu. Brusentsev, M. A. Tikhonova, Yu. E. Herbeck, D. S. Ragaeva, I. N. Rozhkova, S. Ya. Amstislavsky. Developmental aspects of senescence. Russ J Dev Biol 2017;48:93
    https://doi.org/10.1134/S1062360417020035
  63. Kristina Ramdial, Maria Clara Franco, Alvaro G. Estevez. Cellular mechanisms of peroxynitrite-induced neuronal death. Brain Research Bulletin 2017;133:4
    https://doi.org/10.1016/j.brainresbull.2017.05.008
  64. Xiaoying Li, Yu Cao, Xinmiao Yu, Feng Jin, Yang Li. A novel autophagy-related genes prognostic risk model and validation of autophagy-related oncogene VPS35 in breast cancer. Cancer Cell Int 2021;21
    https://doi.org/10.1186/s12935-021-01970-4
  65. Amit Kumar Chauhan, Birendra Nath Mallick. Association between autophagy and rapid eye movement sleep loss-associated neurodegenerative and patho-physio-behavioral changes. Sleep Medicine 2019;63:29
    https://doi.org/10.1016/j.sleep.2019.04.019
  66. Amity F. Eaton, Maria Merkulova, Dennis Brown. The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease. American Journal of Physiology-Cell Physiology 2021;320:C392
    https://doi.org/10.1152/ajpcell.00442.2020
  67. Yan Li, Lidan Liu, Yue Tian, Jin Zhang. Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. Mol Med Report 2019
    https://doi.org/10.3892/mmr.2019.10541
  68. Lubin Huang, Kejing Huang, Hong Ning. Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats. Biomedicine & Pharmacotherapy 2018;98:460
    https://doi.org/10.1016/j.biopha.2017.12.097
  69. Dongmei Wang, Xinmiao Ji, Juanjuan Liu, Zhiyuan Li, Xin Zhang. Dopamine Receptor Subtypes Differentially Regulate Autophagy. IJMS 2018;19:1540
    https://doi.org/10.3390/ijms19051540
  70. Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Robert J. Shmookler Reis. Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2. Sci Rep 2018;8
    https://doi.org/10.1038/s41598-018-33143-1
  71. Shinrye Lee, Myungjin Jo, Younghwi Kwon, Yu-Mi Jeon, Seyeon Kim, Kea Joo Lee, Hyung-Jun Kim. PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403. Journal of Neurogenetics 2023;37:10
    https://doi.org/10.1080/01677063.2022.2114471
  72. Maheedhar Kodali, Tanvi Jankay, Ashok K. Shetty, Doodipala Samba Reddy. Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans. Psychopharmacology 2023;240:673
    https://doi.org/10.1007/s00213-023-06319-5
  73. Nandini Ramesh, Udai Bhan Pandey. Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand. Front. Mol. Neurosci. 2017;10
    https://doi.org/10.3389/fnmol.2017.00263
  74. Shang-Der Chen, Jenq-Lin Yang, Wei-Chao Hwang, Ding-I Yang. Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond. IJMS 2018;19:2423
    https://doi.org/10.3390/ijms19082423
  75. Joshua S Talboom, Ramon Velazquez, Salvatore Oddo. The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer’s disease. npj Aging Mech Dis 2015;1
    https://doi.org/10.1038/npjamd.2015.8
  76. Xue Chen, Tong Zhang, Yulin Zhang. Endoplasmic reticulum stress and autophagy in HIV-1-associated neurocognitive disorders. J. Neurovirol. 2020;26:824
    https://doi.org/10.1007/s13365-020-00906-4
  77. Khaled S. Abd-Elrahman, Awatif Albaker, Jessica M. de Souza, Fabiola M. Ribeiro, Michael G. Schlossmacher, Mario Tiberi, Alison Hamilton, Stephen S. G. Ferguson. Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner. Sci. Signal. 2020;13
    https://doi.org/10.1126/scisignal.abd2494
  78. S.I. Sherwani, H.A. Khan. Trace Amines and Neurological Disorders. 2020.
    https://doi.org/10.1016/B978-0-12-803603-7.00018-5
  79. Ziyan Zhang, Mahfuzur Miah, Megan Culbreth, Michael Aschner. Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity. Neurochem Res 2016;41:409
    https://doi.org/10.1007/s11064-016-1844-x
  80. Sarmistha Mitra, Neha Kaushik, Il Soo Moon, Eun Ha Choi, Nagendra Kumar Kaushik. Utility of Reactive Species Generation in Plasma Medicine for Neuronal Development. Biomedicines 2020;8:348
    https://doi.org/10.3390/biomedicines8090348
  81. Junyang Li, Chao Tang, Liwen Li, Rujun Li, Youwu Fan. Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitro. J Neurooncol 2016;129:39
    https://doi.org/10.1007/s11060-016-2149-2
  82. David R. Graykowski, Yi-Zhi Wang, Arun Upadhyay, Jeffrey N. Savas. The Dichotomous Role of Extracellular Vesicles in the Central Nervous System. iScience 2020;23:101456
    https://doi.org/10.1016/j.isci.2020.101456
  83. Xiangqing Li, Jinqiu Song, Ruijian Dong. Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer’s disease. Cytotechnology 2019;71:679
    https://doi.org/10.1007/s10616-019-00313-6
  84. Franziska Hommen, Saygın Bilican, David Vilchez. Protein clearance strategies for disease intervention. J Neural Transm 2022;129:141
    https://doi.org/10.1007/s00702-021-02431-y
  85. Angeles Aroca, Cecilia Gotor. Hydrogen Sulfide: A Key Role in Autophagy Regulation from Plants to Mammalians. Antioxidants 2022;11:327
    https://doi.org/10.3390/antiox11020327
  86. Carlo Rinaldi, Imre Mäger, Matthew J. Wood. Proteostasis and Diseases of the Motor Unit. Front. Mol. Neurosci. 2016;9
    https://doi.org/10.3389/fnmol.2016.00164
  87. Mukul Jain, Nil Patil, Gholamreza Abdi, Maryam Abbasi Tarighat, Arifullah Mohammed, Muhammad Rajaei Ahmad Mohd Zain, Khang Wen Goh. Mechanistic Insights and Potential Therapeutic Approaches in PolyQ Diseases via Autophagy. Biomedicines 2023;11:162
    https://doi.org/10.3390/biomedicines11010162
  88. Carlo Rodolfo, Silvia Campello, Francesco Cecconi. Mitophagy in neurodegenerative diseases. Neurochemistry International 2018;117:156
    https://doi.org/10.1016/j.neuint.2017.08.004
  89. Arthur Sefiani, Cédric G. Geoffroy. The Potential Role of Inflammation in Modulating Endogenous Hippocampal Neurogenesis After Spinal Cord Injury. Front. Neurosci. 2021;15
    https://doi.org/10.3389/fnins.2021.682259
  90. Juyi Zhang, Guiqiang Yuan, Tianyu Liang, Pengjie Pan, Xiang Li, Haiying Li, Haitao Shen, Zhong Wang, Gang Chen. Nix Plays a Neuroprotective Role in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats. Front. Neurosci. 2020;14
    https://doi.org/10.3389/fnins.2020.00245
  91. Marco Kirchenwitz, Stephanie Stahnke, Kyra Grunau, Lars Melcher, Marco van Ham, Klemens Rottner, Anika Steffen, Theresia E. B. Stradal. The autophagy inducer SMER28 attenuates microtubule dynamics mediating neuroprotection. Sci Rep 2022;12
    https://doi.org/10.1038/s41598-022-20563-3
  92. Yupei Cheng, Bangqi Wu, Jingjie Huang, Yameng Chen. Research Progress on the Mechanisms of Central Post-Stroke Pain: A Review. Cell Mol Neurobiol 2023;43:3083
    https://doi.org/10.1007/s10571-023-01360-6
  93. Lin Wang, Zhihui Tan, Ying Zhang, Nankoria Kady Keita, Huining Liu, Yu Zhang. ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells. Int J Oncol 2020
    https://doi.org/10.3892/ijo.2020.5007
  94. James J. McCormick, Karol Dokladny, Pope L. Moseley, Glen P. Kenny. Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease. Journal of Applied Physiology 2021;130:1
    https://doi.org/10.1152/japplphysiol.00542.2020
  95. Shree Padma Metur, Yuchen Lei, Zhihai Zhang, Daniel J. Klionsky. Regulation of autophagy gene expression and its implications in cancer. 2023;136
    https://doi.org/10.1242/jcs.260631
  96. Yanjie Guan, Yifei Wang, Bo Li, Kai Shen, Quanfu Li, Yingyin Ni, Lei Huang. Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics. Cancer Cell Int 2021;21
    https://doi.org/10.1186/s12935-021-02065-w
  97. Olivier Camuzard, Sabine Santucci-Darmanin, Georges F. Carle, Valérie Pierrefite-Carle. Autophagy in the crosstalk between tumor and microenvironment. Cancer Letters 2020;490:143
    https://doi.org/10.1016/j.canlet.2020.06.015
  98. Zhan-ying Hu, Bo Chen, Jing-pu Zhang, Yuan-yuan Ma. Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease. Journal of Biological Chemistry 2017;292:18062
    https://doi.org/10.1074/jbc.M116.764795
  99. Rim Diab, Federica Pilotto, Smita Saxena. Autophagy and neurodegeneration: Unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology. Front. Cell. Neurosci. 2023;17
    https://doi.org/10.3389/fncel.2023.1086895
  100. Sarbari Saha, Debasna P. Panigrahi, Shankargouda Patil, Sujit K. Bhutia. Autophagy in health and disease: A comprehensive review. Biomedicine & Pharmacotherapy 2018;104:485
    https://doi.org/10.1016/j.biopha.2018.05.007
  101. Yu Dong, Zhe-Ling Feng, Hu-Biao Chen, Fu-Sheng Wang, Jia-Hong Lu. Corni Fructus: a review of chemical constituents and pharmacological activities. Chin Med 2018;13
    https://doi.org/10.1186/s13020-018-0191-z
  102. Midhun B Thomas, Divya Prakash Gnanadhas, Prasanta K Dash, Jatin Machhi, Zhiyi Lin, JoEllyn McMillan, Benson Edagwa, Harris Gelbard, Howard E Gendelman, Santhi Gorantla. Modulating cellular autophagy for controlled antiretroviral drug release. Nanomedicine 2018;13:2139
    https://doi.org/10.2217/nnm-2018-0224
  103. Dan-Jing Yang, Liang Zhu, Jie Ren, Rong-Jie Ma, Hongwen Zhu, Jun Xu. Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model. Neurosci. Bull. 2015;31:445
    https://doi.org/10.1007/s12264-015-1541-9
  104. Jihoon Nah, Shigeki Miyamoto, Junichi Sadoshima. Comprehensive Physiology. 2015.
    https://doi.org/10.1002/cphy.c170005
  105. Manish Bodas, Neeraj Vij. Augmenting autophagy for prognosis based intervention of COPD-pathophysiology. Respir Res 2017;18
    https://doi.org/10.1186/s12931-017-0560-7
  106. Ankit Sharma, Kavyashree Narasimha, Ravi Manjithaya, Vasu Sheeba. Restoration of Sleep and Circadian Behavior by Autophagy Modulation in Huntington's Disease. J. Neurosci. 2023;43:4907
    https://doi.org/10.1523/JNEUROSCI.1894-22.2023
  107. Xianjuan Kou, Ning Chen. Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer’s Disease. Nutrients 2017;9:927
    https://doi.org/10.3390/nu9090927
  108. Qing Tang, Xiangning Li, Jiou Wang. Tubulin deacetylase NDST3 modulates lysosomal acidification: Implications in neurological diseases. BioEssays 2022;44
    https://doi.org/10.1002/bies.202200110
  109. R. E. Foulger, P. Denny, J. Hardy, M. J. Martin, T. Sawford, R. C. Lovering. Using the Gene Ontology to Annotate Key Players in Parkinson’s Disease. Neuroinform 2016;14:297
    https://doi.org/10.1007/s12021-015-9293-2
  110. Bok-Seok Kim, Jin-A Song, Ki-Hong Jang, Taeik Jang, Bumjun Jung, Sung-Eun Yoo, Jae Moon Lee, Eunhee Kim. Pharmacological Intervention Targeting FAF1 Restores Autophagic Flux for α-Synuclein Degradation in the Brain of a Parkinson’s Disease Mouse Model. ACS Chem. Neurosci. 2022;13:806
    https://doi.org/10.1021/acschemneuro.1c00828
  111. Xuan Qin, Xiaodong Shi, Licheng Tu, Yue Ma, Ziyuan Zhou, Rongtong Zhao, Meimiao Zhan, Feng Yin, Zigang Li. Autophagy inducing cyclic peptides constructed by methionine alkylation. Chem. Commun. 2019;55:4198
    https://doi.org/10.1039/C9CC01027K
  112. Fatemeh Saadatpour, Fatemeh Mohammadipanah, Nazanin Zohourian, Mahshid Hodjat. Potential of nanoparticles and nanopolymers in treatment of age-associated diseases. Adv. Nat. Sci: Nanosci. Nanotechnol. 2021;12:045008
    https://doi.org/10.1088/2043-6262/ac42c7
  113. Yong Ni, Wei-Wei Gu, Zhi-He Liu, Yong-Ming Zhu, Jia-Guo Rong, Thomas A. Kent, Min Li, Shi-Gang Qiao, Jian-Zhong An, Hui-Ling Zhang. RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway. Neuroscience 2018;371:60
    https://doi.org/10.1016/j.neuroscience.2017.10.038
  114. Zhanbin Tang, Jingwei Cao, Jialin Yao, Xuehui Fan, Jingkun Zhao, Mianqiao Zhao, Qiong Duan, Baichao Han, Shurong Duan. KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1. Free Radical Biology and Medicine 2023;195:343
    https://doi.org/10.1016/j.freeradbiomed.2022.12.099
  115. Sachchida Nand Rai, Hagera Dilnashin, Hareram Birla, Saumitra Sen Singh, Walia Zahra, Aaina Singh Rathore, Brijesh Kumar Singh, Surya Pratap Singh. The Role of PI3K/Akt and ERK in Neurodegenerative Disorders. Neurotox Res 2019;35:775
    https://doi.org/10.1007/s12640-019-0003-y
  116. Anchala Pandey, Pooja Yadav, Sanjeev Shukla. Unfolding the role of autophagy in the cancer metabolism. Biochemistry and Biophysics Reports 2021;28:101158
    https://doi.org/10.1016/j.bbrep.2021.101158
  117. Pan Fan, Xing-Hui Xie, Chang-Hong Chen, Xin Peng, Po Zhang, Cheng Yang, Yun-Tao Wang. Molecular Regulation Mechanisms and Interactions Between Reactive Oxygen Species and Mitophagy. DNA and Cell Biology 2019;38:10
    https://doi.org/10.1089/dna.2018.4348
  118. Subhashree Sahoo, Amrita Arpita Padhy, Varsha Kumari, Parul Mishra. Role of Ubiquitin–Proteasome and Autophagy-Lysosome Pathways in α-Synuclein Aggregate Clearance. Mol Neurobiol 2022;59:5379
    https://doi.org/10.1007/s12035-022-02897-1
  119. Yanfang Yang, Yu He, Xixi Wang, Ziwei liang, Gu He, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang. Protein SUMOylation modification and its associations with disease. Open Biol. 2017;7:170167
    https://doi.org/10.1098/rsob.170167
  120. Nouri, Fakhri, El-Senduny, Sanadgol, Abd-ElGhani, Farzaei, Chen. On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective. Biomolecules 2019;9:690
    https://doi.org/10.3390/biom9110690
  121. Fengjuan Jiao, Bojie Zhou, Lingyan Meng. The regulatory mechanism and therapeutic potential of transcription factor EB in neurodegenerative diseases. CNS Neurosci Ther 2023;29:37
    https://doi.org/10.1111/cns.13985
  122. Irene Maeve Rea, David S. Gibson, Victoria McGilligan, Susan E. McNerlan, H. Denis Alexander, Owen A. Ross. Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines. Front. Immunol. 2018;9
    https://doi.org/10.3389/fimmu.2018.00586
  123. Honggang Xiang, Jifa Zhang, Congcong Lin, Lan Zhang, Bo Liu, Liang Ouyang. Targeting autophagy-related protein kinases for potential therapeutic purpose. Acta Pharmaceutica Sinica B 2020;10:569
    https://doi.org/10.1016/j.apsb.2019.10.003
  124. Tarapati Rana, Tapan Behl, Aayush Sehgal, Vineet Mehta, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau. Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders. Mol Neurobiol 2021;58:4886
    https://doi.org/10.1007/s12035-021-02472-0
  125. Mehdi Mirzaei, Morteza Abyadeh, Anita J. Turner, Roshana Vander Wall, Joel M. Chick, Joao A. Paulo, Veer K. Gupta, Devaraj Basavarajappa, Nitin Chitranshi, Seyed Shahab Oddin Mirshahvaladi, Yuyi You, Matthew J. Fitzhenry, Ardeshir Amirkhani, Paul A. Haynes, Alexander Klistorner, Vivek Gupta, Stuart L. Graham. Fingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy, and neuroinflammatory networks. Proteomics 2022;22
    https://doi.org/10.1002/pmic.202100247
  126. Yoshinori Tanaka, Takashi Nonaka, Genjiro Suzuki, Fuyuki Kametani, Masato Hasegawa. Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation. Hum. Mol. Genet. 2016;25:1420
    https://doi.org/10.1093/hmg/ddw024
  127. Kai-liang Zhou, Yi-fei Zhou, Kai Wu, Nai-feng Tian, Yao-sen Wu, Yong-li Wang, De-heng Chen, Bin Zhou, Xiang-yang Wang, Hua-zi Xu, Xiao-lei Zhang. Stimulation of autophagy promotes functional recovery in diabetic rats with spinal cord injury. Sci Rep 2015;5
    https://doi.org/10.1038/srep17130
  128. Dong-Won Lee, Yong-Sik Hong, Sung-Hee Oh, Yoo-Hyun Lee, Jeong-Sun Ju. The Effects of 8-Week Endurance Training on Prostatic Autophagy and Benign Prostatic Hyperplasia of Rats. Exerc Sci 2019;28:270
    https://doi.org/10.15857/ksep.2019.28.3.270
  129. Patrycja Michalska, Rafael León. When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration. Antioxidants 2020;9:740
    https://doi.org/10.3390/antiox9080740
  130. Qin Yang, Xiaohong Li, Rongqing Li, Juan Peng, Zuo Wang, Zhisheng Jiang, Xiaoqing Tang, Zhao Peng, Yu Wang, Dangheng Wei. Low Shear Stress Inhibited Endothelial Cell Autophagy Through TET2 Downregulation. Ann Biomed Eng 2016;44:2218
    https://doi.org/10.1007/s10439-015-1491-4
  131. Xuemei Bai, Song Liu, Lin Yuan, Yunkai Xie, Tong Li, Lingxiao Wang, Xueer Wang, Tiantian Zhang, Shucun Qin, Guohau Song, Li Ge, Zhen Wang. Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Research 2016;1646:410
    https://doi.org/10.1016/j.brainres.2016.06.020
  132. Federica Cavaliere, Alessandra Fornarelli, Fabio Bertan, Rossella Russo, Anaïs Marsal-Cots, Luigi Antonio Morrone, Annagrazia Adornetto, Maria Tiziana Corasaniti, Daniele Bano, Giacinto Bagetta, Pierluigi Nicotera. The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-40887-x
  133. Maria A. Tikhonova. A new avenue for treating Parkinson's disease targeted at aggrephagy modulation and neuroinflammation: Insights from in vitro and animal studies. EBioMedicine 2020;51:102575
    https://doi.org/10.1016/j.ebiom.2019.11.036
  134. Miguel Pareja-Cajiao, Heather M. Gransee, Jessica M. Stowe, Sabhya Rana, Gary C. Sieck, Carlos B. Mantilla. Age-related impairment of autophagy in cervical motor neurons. Experimental Gerontology 2021;144:111193
    https://doi.org/10.1016/j.exger.2020.111193
  135. Savina Apolloni, Paola Fabbrizio, Susanna Amadio, Cinzia Volonté. Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression. J Neuroinflammation 2016;13
    https://doi.org/10.1186/s12974-016-0658-8
  136. Nada Saewanee, Theethawat Praputpittaya, Nawaphat Malaiwong, Pawanrat Chalorak, Krai Meemon. Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson’s disease. Neuroscience Research 2021;162:13
    https://doi.org/10.1016/j.neures.2019.12.017
  137. Vincent Kam Wai Wong, Wu Zeng, Juan Chen, Xiao Jun Yao, Elaine Lai Han Leung, Qian Qian Wang, Pauline Chiu, Ben C. B. Ko, Betty Yuen Kwan Law. Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms. Front. Pharmacol. 2017;8
    https://doi.org/10.3389/fphar.2017.00351
  138. Wei Xie, Jun Zhou. Aberrant regulation of autophagy in mammalian diseases. Biol. Lett. 2018;14:20170540
    https://doi.org/10.1098/rsbl.2017.0540
  139. Tao Long, Yong Tang, Yan-Ni He, Chang-Long He, Xue Chen, Min-Song Guo, Jian-Ming Wu, Lu Yu, Chong-Lin Yu, Betty Yuen-Kwan Law, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou, Rozalyn M Anderson. Citri Reticulatae Semen Extract Promotes Healthy Aging and Neuroprotection via Autophagy Induction in Caenorhabditis elegans . 2022;77:2186
    https://doi.org/10.1093/gerona/glac136
  140. Karen Libberecht, Tim Vangansewinkel, Ludo Van Den Bosch, Ivo Lambrichts, Esther Wolfs. Proteostasis plays an important role in demyelinating Charcot Marie Tooth disease. Biochemical Pharmacology 2023;216:115760
    https://doi.org/10.1016/j.bcp.2023.115760
  141. R. Yu. Shadrina, A. I. Yemets, Ya. B. Blume. Autophagy development as an adaptive response to microgravity conditions in Arabidopsis thaliana. Fakt. eksp. evol. org. 2019;25:327
    https://doi.org/10.7124/FEEO.v25.1186
  142. Sylviane Muller, Susana Brun, Frédérique René, Jérôme de Sèze, Jean-Philippe Loeffler, Hélène Jeltsch-David. Autophagy in neuroinflammatory diseases. Autoimmunity Reviews 2017;16:856
    https://doi.org/10.1016/j.autrev.2017.05.015
  143. Gal Chaim Nuta, Yuval Gilad, Nadav Goldberg, Sara Meril, Marcela Bahlsen, Silvia Carvalho, Noga Kozer, Haim Barr, Yael Fridmann Sirkis, Kamil Hercík, Petra Břehová, Radim Nencka, Shani Bialik, Miriam Eisenstein, Adi Kimchi. Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction. Autophagy 2023;19:2372
    https://doi.org/10.1080/15548627.2023.2178159
  144. Simon Michaeli, Gad Galili, Pascal Genschik, Alisdair R. Fernie, Tamar Avin-Wittenberg. Autophagy in Plants – What's New on the Menu?. Trends in Plant Science 2016;21:134
    https://doi.org/10.1016/j.tplants.2015.10.008
  145. Andrew P. Shoubridge, Célia Fourrier, Jocelyn M. Choo, Christopher G. Proud, Timothy J. Sargeant, Geraint B. Rogers. Gut Microbiome Regulation of Autophagic Flux and Neurodegenerative Disease Risks. Front. Microbiol. 2021;12
    https://doi.org/10.3389/fmicb.2021.817433
  146. Xiangming Xu, Lili Cui, Wangtao Zhong, Yujie Cai. Autophagy-Associated lncRNAs: Promising Targets for Neurological Disease Diagnosis and Therapy. Neural Plasticity 2020;2020:1
    https://doi.org/10.1155/2020/8881687
  147. Mariana Abrantes do Amaral, Lais Cavalieri Paredes, Barbara Nunes Padovani, Juliana Moreira Mendonça-Gomes, Luan Fávero Montes, Niels Olsen Saraiva Câmara, Camila Morales Fénero. Mitochondrial connections with immune system in Zebrafish. Fish and Shellfish Immunology Reports 2021;2:100019
    https://doi.org/10.1016/j.fsirep.2021.100019
  148. Ching-Chi Chang, Tzu-Chin Lin, Hsiao-Li Ho, Chien-Yin Kuo, Hsin-Hua Li, Tatiana Korolenko, Wei-Jen Chen, Te-Jen Lai, Ying-Jui Ho, Chih-Li Lin. GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. IJMS 2018;19:2505
    https://doi.org/10.3390/ijms19092505
  149. Reinis Svarcbahs, Maria Jäntti, Tommi Kilpeläinen, Ulrika H. Julku, Lauri Urvas, Saara Kivioja, Susanna Norrbacka, Timo T. Myöhänen. Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A. Pharmacological Research 2020;151:104558
    https://doi.org/10.1016/j.phrs.2019.104558
  150. Valeriya Gyurkovska, Rakhilya Murtazina, Sarah F Zhao, Sojin Shikano, Yukari Okamoto, Nava Segev. Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence. Life Sci. Alliance 2023;6:e202201810
    https://doi.org/10.26508/lsa.202201810
  151. WEILIN LIU, GUANHAO SHANG, SHANLI YANG, JIA HUANG, XIEHUA XUE, YUNJIAO LIN, YI ZHENG, XIAN WANG, LULU WANG, RUHUI LIN, JING TAO, LIDIAN CHEN. Electroacupuncture protects against ischemic stroke by reducing autophagosome formation and inhibiting autophagy through the mTORC1-ULK1 complex-Beclin1 pathway. 2016;37:309
    https://doi.org/10.3892/ijmm.2015.2425
  152. Khaled S. Abd-Elrahman, Stephen S. G. Ferguson. Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice. Mol Brain 2019;12
    https://doi.org/10.1186/s13041-019-0456-1
  153. Longxue Cai, Xianfa Liu, Qicai Guo, Qi huang, Qiong Zhang, Zuohong Cao. MiR-15a attenuates peripheral nerve injury-induced neuropathic pain by targeting AKT3 to regulate autophagy. Genes Genom 2020;42:77
    https://doi.org/10.1007/s13258-019-00881-z
  154. Xianjuan Kou, Meng Zhang, Hu Zhang, Michael Kirberger, Ning Chen. Exercise, Autophagy and Chronic Diseases. 2020.
    https://doi.org/10.1007/978-981-16-4525-9_7
  155. Dirk Balke, Lars Tatenhorst, Vivian Dambeck, Vinicius Toledo Ribas, Björn F. Vahsen, Uwe Michel, Mathias Bähr, Paul Lingor. AAV-Mediated Expression of Dominant-Negative ULK1 Increases Neuronal Survival and Enhances Motor Performance in the MPTP Mouse Model of Parkinson’s Disease. Mol Neurobiol 2020;57:685
    https://doi.org/10.1007/s12035-019-01744-0
  156. Xiaoyi Zhang, Quanzhong Su, Ji Zhou, Zhihong Yang, Zhantao Liu, Lixia Ji, Hui Gao, Guohui Jiang. To betray or to fight? The dual identity of the mitochondria in cancer. Future Oncology 2021;17:723
    https://doi.org/10.2217/fon-2020-0362