Molecules and Cells

Cited by CrossRef (33)

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  3. Zhishan Xu, Yuliang Yang, Xianglei Jia, Lihua Guo, Xingxing Ge, Genshen Zhong, Shujiao Chen, Zhe Liu. Novel cyclometalated iridium(iii) phosphine-imine (P^N) complexes: highly efficient anticancer and anti-lung metastasis agents in vivo. Inorg. Chem. Front. 2020;7:1273
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  4. Martyna Wojtala, Ewa Macierzyńska-Piotrowska, Dorota Rybaczek, Luciano Pirola, Aneta Balcerczyk. Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells. Pharmacological Research 2018;128:252
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  5. Abrar Mohammad Sayaf, Saif Ullah Khalid, Jawad Ahmed Hameed, Abdulrahman Alshammari, Abbas Khan, Anwar Mohammad, Saeed Alghamdi, Dong-Qing Wei, KarKheng Yeoh. Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD). Front. Pharmacol. 2023;14
    https://doi.org/10.3389/fphar.2023.1202128
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  7. Tina Schönberger, Joachim Fandrey, Katrin Prost-Fingerle. Ways into Understanding HIF Inhibition. Cancers 2021;13:159
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  8. Xiujuan Wang, Kun Liu, Bin Li, Yanning Li, Kaiwei Ye, Jinsheng Qi, Yu Wang. Macrophages Aggravate Hypoxia-Induced Cardiac Microvascular Endothelial Cell Injury via Peroxynitrite: Protection by Tongxinluo. Cell Communication & Adhesion 2015;22:39
    https://doi.org/10.3109/15419061.2016.1155565
  9. Jin Rong Ow, Monica Palanichamy Kala, Vinay Kumar Rao, Min Hee Choi, Narendra Bharathy, Reshma Taneja. G9a inhibits MEF2C activity to control sarcomere assembly. Sci Rep 2016;6
    https://doi.org/10.1038/srep34163
  10. Christian Mayr, Katharina Helm, Martin Jakab, Markus Ritter, Rajeev Shrestha, Ramesh Makaju, Andrej Wagner, Martin Pichler, Marlena Beyreis, Stefan Staettner, Tarkan Jaeger, Eckhard Klieser, Tobias Kiesslich, Daniel Neureiter. The histone methyltransferase G9a: a new therapeutic target in biliary tract cancer. Human Pathology 2018;72:117
    https://doi.org/10.1016/j.humpath.2017.11.003
  11. Tiansheng Li, Chao Mao, Xiang Wang, Ying Shi, Yongguang Tao. Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation. J Exp Clin Cancer Res 2020;39
    https://doi.org/10.1186/s13046-020-01733-5
  12. Steven J. Deimling, Jonathan B. Olsen, Vincent Tropepe. The expanding role of the Ehmt2/G9a complex in neurodevelopment. Neurogenesis 2017;4:e1316888
    https://doi.org/10.1080/23262133.2017.1316888
  13. Seon Min Woo, Seung Un Seo, Kyoung-Jin Min, Taeg Kyu Kwon. BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression. Cell Death Discovery 2018;4
    https://doi.org/10.1038/s41420-018-0035-8
  14. M. Francis, G. Gopinathan, D. Foyle, P. Fallah, M. Gonzalez, X. Luan, T.G.H. Diekwisch. Histone Methylation: Achilles Heel and Powerful Mediator of Periodontal Homeostasis. J Dent Res 2020;99:1332
    https://doi.org/10.1177/0022034520932491
  15. Jolene Caifeng Ho, Lissa Nurrul Abdullah, Qing You Pang, Sudhakar Jha, Edward Kai-Hua Chow, Henry Yang, Hiroyuki Kato, Lorenz Poellinger, Jun Ueda, Kian Leong Lee, Aamir Ahmad. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway. PLoS ONE 2017;12:e0188051
    https://doi.org/10.1371/journal.pone.0188051
  16. Weibo Luo, Yingfei Wang. Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity. Cell. Mol. Life Sci. 2018;75:1043
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  17. Yan Zhao, Cheng Xing, Yating Deng, Can Ye, Hongling Peng. HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies. Genes & Diseases 2024;11:234
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  18. Ellen G. Jarred, Heidi Bildsoe, Patrick S. Western. Out of sight, out of mind? Germ cells and the potential impacts of epigenomic drugs. F1000Res 2018;7:1967
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  19. Yanyan Qian, Yiping Li, Chuqian Zheng, Tianyu Lu, Rui Sun, Yuhang Mao, Shenling Yu, Hong Fan, Zhihong Zhang. High methylation levels of histone H3 lysine 9 associated with activation of hypoxia-inducible factor 1α (HIF-1α) predict patients’ worse prognosis in human hepatocellular carcinomas. Cancer Genetics 2020;245:17
    https://doi.org/10.1016/j.cancergen.2020.04.077
  20. Huining Tian, Xiaoyu Zhu, You Lv, Yan Jiao, Guixia Wang.

    Glucometabolic Reprogramming in the Hepatocellular Carcinoma Microenvironment: Cause and Effect

    . CMAR 2020;Volume 12:5957
    https://doi.org/10.2147/CMAR.S258196
  21. Shanshan Wan, Wanju Yang, Yumiao Pan, Zhuoqun Rao, Yanning Yang. G9a Suppression Alleviates Corneal Neovascularization through Blocking Nox4-Mediated Oxidative Stress. Oxidative Medicine and Cellular Longevity 2020;2020:1
    https://doi.org/10.1155/2020/6983268
  22. Luciano Pirola, Oskar Ciesielski, Aneta Balcerczyk. The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting. Cancers 2018;10:268
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  23. Lingyue Gao, Lihui Wang. Epigenetic Regulation in Overcoming Chemoresistance. 2018.
    https://doi.org/10.1016/B978-0-12-823684-0.00015-3
  24. Shinjini Bandopadhyay, Somi Patranabis. Mechanisms of HIF-driven immunosuppression in tumour microenvironment. J Egypt Natl Canc Inst 2023;35
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  25. Xiang Wei, Xin Yi, Xue-Hai Zhu, Ding-Sheng Jiang. Histone methylation and vascular biology. Clin Epigenet 2020;12
    https://doi.org/10.1186/s13148-020-00826-4
  26. SunilGowda Sunnaghatta Nagaraja, Umadevi Subramanian, Devipriya Nagarajan. Radiation-induced H3K9 methylation on E-cadherin promoter mediated by ROS/Snail axis : Role of G9a signaling during lung epithelial-mesenchymal transition. Toxicology in Vitro 2021;70:105037
    https://doi.org/10.1016/j.tiv.2020.105037
  27. Lan-Ting Yuan, Wei-Jiunn Lee, Yi-Chieh Yang, Bo-Rong Chen, Ching-Yao Yang, Min-Wei Chen, Ji-Qing Chen, Michael Hsiao, Ming-Hsien Chien, Kuo-Tai Hua. Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122. Cancers 2021;13:2376
    https://doi.org/10.3390/cancers13102376
  28. Daniel J. García-Domínguez, Nabil Hajji, Roser López-Alemany, Sara Sánchez-Molina, Elisabet Figuerola-Bou, Francisco J. Morón Civanto, Santiago Rello-Varona, Eduardo Andrés-León, Adrián Benito, Hector C. Keun, Jaume Mora, Óscar M. Tirado, Enrique de Álava, Lourdes Hontecillas-Prieto. Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1. Oncogene 2022;41:2638
    https://doi.org/10.1038/s41388-022-02279-w
  29. Najah Albadari, Shanshan Deng, Wei Li. The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy. Expert Opinion on Drug Discovery 2019;14:667
    https://doi.org/10.1080/17460441.2019.1613370
  30. Steven G. Gray. Handbook of Nutrition, Diet, and Epigenetics. 2019.
    https://doi.org/10.1007/978-3-319-55530-0_36
  31. Gregg L. Semenza. Pharmacologic Targeting of Hypoxia-Inducible Factors. Annu. Rev. Pharmacol. Toxicol. 2019;59:379
    https://doi.org/10.1146/annurev-pharmtox-010818-021637
  32. Shilei Zhang, Fukai Gong, Jiali Liu, Tao Liu, Jianhua Yang, Junping Hu. A novel PHD2 inhibitor acteoside from Cistanche tubulosa induces skeletal muscle mitophagy to improve cancer-related fatigue. Biomedicine & Pharmacotherapy 2022;150:113004
    https://doi.org/10.1016/j.biopha.2022.113004
  33. Steven G. Gray. Handbook of Nutrition, Diet, and Epigenetics. 2022.
    https://doi.org/10.1007/978-3-319-31143-2_36-1