Molecules and Cells

Cited by CrossRef (130)

  1. Eoghan J. Mulholland, Ahlam Ali, Tracy Robson, Nicholas J. Dunne, Helen O. McCarthy. Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair. Journal of Controlled Release 2019;316:53
    https://doi.org/10.1016/j.jconrel.2019.10.050
  2. Fan Yang, Xiangjun Bai, Xiaojing Dai, Yong Li. The biological processes during wound healing. Regenerative Medicine 2021;16:373
    https://doi.org/10.2217/rme-2020-0066
  3. Eoin P. Cummins, Daniel Crean. Hypoxia and inflammatory bowel disease. Microbes and Infection 2017;19:210
    https://doi.org/10.1016/j.micinf.2016.09.004
  4. Lara Batičić Pučar, Antonijo Grčić, Ester Pernjak Pugel, Dijana Detel, Jadranka Varljen. Wound healing process and dipeptidyl peptidase IV. Med. flum. 2017;53:4
    https://doi.org/10.21860/medflum2017_173375
  5. Céline M. Desmet, Véronique Préat, Bernard Gallez. Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing. Advanced Drug Delivery Reviews 2018;129:262
    https://doi.org/10.1016/j.addr.2018.02.001
  6. Alexander I. Kostyuk, Aleksandra D. Kokova, Oleg V. Podgorny, Ilya V. Kelmanson, Elena S. Fetisova, Vsevolod V. Belousov, Dmitry S. Bilan. Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia. Antioxidants 2020;9:516
    https://doi.org/10.3390/antiox9060516
  7. Bo-Yoon Park, Dirong Wu, Kyoo-Ri Kwon, Mi-Jin Kim, Tae-Gon Kim, Jun-Ho Lee, Do Young Park, Il-Kug Kim. Implantation and tracing of green fluorescent protein-expressing adipose-derived stem cells in peri-implant capsular fibrosis. Stem Cell Res Ther 2023;14
    https://doi.org/10.1186/s13287-023-03248-0
  8. Barbara Casella Amorim, Ana Carla Pereira-Latini, Márjorie de Assis Golim, Raul Lopes Ruiz Júnior, Hugo Hyung Bok Yoo, Maria Sueli Parreira de Arruda, Aldo Henrique Tavares, Ricardo de Souza Cavalcante, Rinaldo Poncio Mendes, Alessandra Pontillo, James Venturini. Enhanced expression of NLRP3 inflammasome components by monocytes of patients with pulmonary paracoccidioidomycosis is associated with smoking and intracellular hypoxemia. Microbes and Infection 2020;22:137
    https://doi.org/10.1016/j.micinf.2019.11.001
  9. Sampath Narayanan, Sofie Eliasson Angelstig, Cheng Xu, Jacob Grünler, Allan Zhao, Wan Zhu, Ning Xu Landén, Mona Ståhle, Jingping Zhang, Mircea Ivan, Raluca Georgiana Maltesen, Ileana Ruxandra Botusan, Neda Rajamand Ekberg, Xiaowei Zheng, Sergiu-Bogdan Catrina. HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism. Commun Biol 2020;3
    https://doi.org/10.1038/s42003-020-01495-y
  10. Irfan Khan, Marium Naz Siddiqui, Fatima Jameel, Rida-e-Maria Qazi, Asmat Salim, Shazmeen Aslam, Midhat Batool Zaidi. Potential of stem cell seeded three-dimensional scaffold for regeneration of full-thickness skin wounds. Interface Focus. 2022;12
    https://doi.org/10.1098/rsfs.2022.0017
  11. Chris J van Koppen, Rolf W Hartmann. Advances in the treatment of chronic wounds: a patent review. Expert Opinion on Therapeutic Patents 2015;25:931
    https://doi.org/10.1517/13543776.2015.1045879
  12. Ian Warbrick, Simon W. Rabkin. Hypoxia‐inducible factor 1‐alpha (HIF‐1α) as a factor mediating the relationship between obesity and heart failure with preserved ejection fraction. Obesity Reviews 2019;20:701
    https://doi.org/10.1111/obr.12828
  13. Silvia Tejada, Juan M. Batle, Miguel D. Ferrer, Carla Busquets-Cortés, Margalida Monserrat-Mesquida, Seyed M. Nabavi, Maria del Mar Bibiloni, Antoni Pons, Antoni Sureda. Therapeutic Effects of Hyperbaric Oxygen in the Process of Wound Healing. CPD 2019;25:1682
    https://doi.org/10.2174/1381612825666190703162648
  14. Moritz J. Strowitzki, Alina S. Ritter, Gwendolyn Kimmer, Martin Schneider. Hypoxia-adaptive pathways: A pharmacological target in fibrotic disease?. Pharmacological Research 2019;147:104364
    https://doi.org/10.1016/j.phrs.2019.104364
  15. Jianzhong Zhu, Cheng Chen, Jie Dong, Shasha Cheng, Guodong Li, Chunming Wang, Defang Ouyang, Chung-Hang Leung, Ligen Lin. Artificial intelligence-aided discovery of prolyl hydroxylase 2 inhibitors to stabilize hypoxia inducible factor-1α and promote angiogenesis. Chinese Chemical Letters 2023;34:107514
    https://doi.org/10.1016/j.cclet.2022.05.028
  16. Cansu Gorgun, Davide Ceresa, Raphaelle Lesage, Federico Villa, Daniele Reverberi, Carolina Balbi, Sara Santamaria, Katia Cortese, Paolo Malatesta, Liesbet Geris, Rodolfo Quarto, Roberta Tasso. Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs). Biomaterials 2021;269:120633
    https://doi.org/10.1016/j.biomaterials.2020.120633
  17. Yasamin Pesaran Afsharian, Mostafa Rahimnejad. Bioactive electrospun scaffolds for wound healing applications: A comprehensive review. Polymer Testing 2021;93:106952
    https://doi.org/10.1016/j.polymertesting.2020.106952
  18. Yong Mao, Vimal Jacob, Amit Singal, Shunyao Lei, Min Sung Park, Mariana R.N. Lima, Chaoyang Li, Sandeep Dhall, Malathi Sathyamoorthy, Joachim Kohn. Exosomes Secreted from Amniotic Membrane Contribute to Its Anti-Fibrotic Activity. IJMS 2021;22:2055
    https://doi.org/10.3390/ijms22042055
  19. John F. Burke, Nicole D. Quinlan, Brian C. Werner, James A. Browne. Use of Supplemental Home Oxygen is Associated With Early Postoperative Complications Following Total Knee Arthroplasty. The Journal of Arthroplasty 2022;37:2186
    https://doi.org/10.1016/j.arth.2022.05.044
  20. Chilan B. G. Leite, Luciana P. Tavares, Magno S. Leite, Marco K. Demange. Revisiting the role of hyperbaric oxygen therapy in knee injuries: Potential benefits and mechanisms. Journal Cellular Physiology 2023;238:498
    https://doi.org/10.1002/jcp.30947
  21. Guodan Zeng, Tao Wang, Jingyao Zhang, Y. James Kang, Li Feng. FLI1 mediates the selective expression of hypoxia‐inducible factor 1 target genes in endothelial cells under hypoxic conditions. FEBS Open Bio 2021;11:2174
    https://doi.org/10.1002/2211-5463.13220
  22. Barani Karikalan, Srikumar Chakravarthi. Genes involved in chronic wound healing and their therapeutic potential. ACHR 2023;8:83
    https://doi.org/10.18231/j.achr.2023.020
  23. Yvonn Heun, Kristin Pogoda, Martina Anton, Joachim Pircher, Alexander Pfeifer, Markus Woernle, Andrea Ribeiro, Petra Kameritsch, Olga Mykhaylyk, Christian Plank, Florian Kroetz, Ulrich Pohl, Hanna Mannell. HIF-1α Dependent Wound Healing Angiogenesis In Vivo Can Be Controlled by Site-Specific Lentiviral Magnetic Targeting of SHP-2. Molecular Therapy 2017;25:1616
    https://doi.org/10.1016/j.ymthe.2017.04.007
  24. Jingti Jing, Haoming Jiang, Lin Zhang. Endothelial progenitor cells promote neural stem cell proliferation in hypoxic conditions through VEGF via the PI3K/AKT pathway. Journal of Receptors and Signal Transduction 2022;42:479
    https://doi.org/10.1080/10799893.2021.2019275
  25. Xian‐Kun Sun, Rao Li, Xiao‐Ling Yang, Li Yuan. Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta‐analysis. International Wound Journal 2022;19:2200
    https://doi.org/10.1111/iwj.13830
  26. Xinyu Zhao, Wei Zhang, Junjuan Fan, Xulin Chen, Xianwen Wang. Application of mesenchymal stem cell exosomes in the treatment of skin wounds. Smart Materials in Medicine 2023;4:578
    https://doi.org/10.1016/j.smaim.2023.04.006
  27. Anna A. Borovikova, Mary E. Ziegler, Derek A. Banyard, Garrett A. Wirth, Keyianoosh Z. Paydar, Gregory R.D. Evans, Alan David Widgerow. Adipose-Derived Tissue in the Treatment of Dermal Fibrosis. 2018;80:297
    https://doi.org/10.1097/SAP.0000000000001278
  28. Shuo Qiu, Yachao Jia, Yunchu Sun, Pei Han, Jia Xu, Gen Wen, Yimin Chai. Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling. Journal of Diabetes Research 2019;2019:1
    https://doi.org/10.1155/2019/1897174
  29. Guodong Li, Chung-Nga Ko, Dan Li, Chao Yang, Wanhe Wang, Guan-Jun Yang, Carmelo Di Primo, Vincent Kam Wai Wong, Yaozu Xiang, Ligen Lin, Dik-Lung Ma, Chung-Hang Leung. A small molecule HIF-1α stabilizer that accelerates diabetic wound healing. Nat Commun 2021;12
    https://doi.org/10.1038/s41467-021-23448-7
  30. Chiara Formica, Hester Happé, Kimberley AM Veraar, Andrea Vortkamp, Marion Scharpfenecker, Helen McNeill, Dorien JM Peters. Four‐jointed knock‐out delays renal failure in an ADPKD model with kidney injury. The Journal of Pathology 2019;249:114
    https://doi.org/10.1002/path.5286
  31. Lucas R. Smith, Elisabeth R. Barton. Regulation of fibrosis in muscular dystrophy. Matrix Biology 2018;68-69:602
    https://doi.org/10.1016/j.matbio.2018.01.014
  32. Kim Jones. Host Response to Biomaterials. 2018.
    https://doi.org/10.1016/B978-0-12-800196-7.00009-8
  33. Ivan Kurniawan Bassar, Jamsari Jamsari, Ellyza Nasrul, Humaryanto Humaryanto. Relationship between Gene Polymorphism of Vascular Endothelial Growth Factor (VEGF) rs699947 with VEGF and Matrix Metalloproteinase-14 Protein Levels in Patient with Diabetic Foot Ulcer. Open Access Maced J Med Sci 2022;10:720
    https://doi.org/10.3889/oamjms.2022.9562
  34. M. N. Kudykin, V. V. Beschastnov, R. A. Deryabin, G. E. Sheiko, L. M. Celousova, A. N. Belova. The role of hypoxia-inducible factorin the syndrome of chronic lower limb ischemia and influence of diabetes mellitus on process of angiogenesis. Regional blood circulation and microcirculation 2017;16:4
    https://doi.org/10.24884/1682-6655-2017-16-3-4-9
  35. Florence Jeny, Jean-François Bernaudin, Dominique Valeyre, Marianne Kambouchner, Marina Pretolani, Hilario Nunes, Carole Planès, Valérie Besnard. Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis. Front. Immunol. 2021;12
    https://doi.org/10.3389/fimmu.2021.719009
  36. Si Young Heo, Myoung Jin Lee, Hyeon jun Kim, Sung Bin Byun. Relationship between Ischemia–Modified Albumin and the Healing Period of Amputation Wounds in Patients with Diabetes Mellitus Following Non-traumatic Below-Knee Amputation. J Korean Foot Ankle Soc 2023;27:49
    https://doi.org/10.14193/jkfas.2023.27.2.49
  37. Angkhana Nilnumkhum, Rattiyaporn Kanlaya, Sunisa Yoodee, Visith Thongboonkerd. Caffeine inhibits hypoxia-induced renal fibroblast activation by antioxidant mechanism. Cell Adhesion & Migration 2019;13:259
    https://doi.org/10.1080/19336918.2019.1638691
  38. Jing Geng, Xiaoxi Huang, Ying Li, Xuefeng Xu, Shuhong Li, Dingyuan Jiang, Zheng Liu, Huaping Dai. Phosphatase and tensin homolog deleted on chromosome 10 contributes to phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis via multiple pathways. Exp Biol Med (Maywood) 2016;241:157
    https://doi.org/10.1177/1535370215600100
  39. Adrian Hautmann, Devaki Kedilaya, Sanja Stojanović, Milena Radenković, Christian K. Marx, Stevo Najman, Markus Pietzsch, João F. Mano, Thomas Groth. Free-standing multilayer films as growth factor reservoirs for future wound dressing applications. Biomaterials Advances 2022;142:213166
    https://doi.org/10.1016/j.bioadv.2022.213166
  40. Shen-Yuan Zheng, Xin-Xing Wan, Piniel Alphayo Kambey, Yan Luo, Xi-Min Hu, Yi-Fan Liu, Jia-Qi Shan, Yu-Wei Chen, Kun Xiong. Therapeutic role of growth factors in treating diabetic wound. World J Diabetes 2023;14:364
    https://doi.org/10.4239/wjd.v14.i4.364
  41. Janina Deppe, Tanja Popp, Virginia Egea, Dirk Steinritz, Annette Schmidt, Horst Thiermann, Christian Weber, Christian Ries. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol 2016;90:1141
    https://doi.org/10.1007/s00204-015-1549-y
  42. Paula Grippa Sant’Ana, Loreta Casquel de Tomasi, Gilson Masahiro Murata, Danielle Fernandes Vileigas, Gustavo Augusto Ferreira Mota, Sérgio Luiz Borges de Souza, Vitor Loureiro Silva, Livia Paschoalino de Campos, Katashi Okoshi, Carlos Roberto Padovani, Antonio Carlos Cicogna. Hypoxia-Inducible Factor 1-Alpha and Glucose Metabolism during Cardiac Remodeling Progression from Hypertrophy to Heart Failure. IJMS 2023;24:6201
    https://doi.org/10.3390/ijms24076201
  43. Bin Yang, Hongwei Chen, Jiawen Cao, Bo He, Shanshan Wang, Yang Luo, Jiakun Wang. Transcriptome Analysis Reveals That Alfalfa Promotes Rumen Development Through Enhanced Metabolic Processes and Calcium Transduction in Hu Lambs. Front. Genet. 2019;10
    https://doi.org/10.3389/fgene.2019.00929
  44. Christopher T.A. Lewis, Keith S. Mascall, Heather M. Wilson, Fiona Murray, Keith M. Kerr, George Gibson, Keith Buchan, Gary R. Small, Graeme F. Nixon. An endogenous inhibitor of angiogenesis downregulated by hypoxia in human aortic valve stenosis promotes disease pathogenesis. Journal of Molecular and Cellular Cardiology 2023;174:25
    https://doi.org/10.1016/j.yjmcc.2022.10.010
  45. Ajoy Aloysius. Tissue Engineering. 2023.
    https://doi.org/10.1016/B978-0-12-824064-9.00020-4
  46. Wei Deng, Xuebing Feng, Xia Li, Dandan Wang, Lingyun Sun. Hypoxia-inducible factor 1 in autoimmune diseases. Cellular Immunology 2016;303:7
    https://doi.org/10.1016/j.cellimm.2016.04.001
  47. Hui-Cong Du, Lin Jiang, Wen-Xin Geng, Jing Li, Rui Zhang, Jin-Ge Dang, Mao-Guo Shu, Li-Wen Li. Growth Factor-Reinforced ECM Fabricated from Chemically Hypoxic MSC Sheet with Improved In Vivo Wound Repair Activity. BioMed Research International 2017;2017:1
    https://doi.org/10.1155/2017/2578017
  48. Mogher Khamaisi, Sarit Balanson. Dysregulation of wound healing mechanisms in diabetes and the importance of negative pressure wound therapy (NPWT). Diabetes Metab Res Rev 2017;33:e2929
    https://doi.org/10.1002/dmrr.2929
  49. Wenpei Dong, Zhicheng Song, Suihong Liu, Ping Yu, Zhipeng Shen, Jianjun Yang, Dongchao Yang, Qinxi Hu, Haiguang Zhang, Yan Gu. Adipose-Derived Stem Cells Based on Electrospun Biomimetic Scaffold Mediated Endothelial Differentiation Facilitating Regeneration and Repair of Abdominal Wall Defects via HIF-1α/VEGF Pathway. Front. Bioeng. Biotechnol. 2021;9
    https://doi.org/10.3389/fbioe.2021.676409
  50. Meriem Hasmim, Yosra Messai, Stéphane Terry, Bassam Janji, Muhammad Zaeem Noman, Salem Chouaib. Resistance of Cancer Cells to CTL-Mediated Immunotherapy. 2021.
    https://doi.org/10.1007/978-3-319-17807-3_6
  51. Hiroyuki Yano, Mashito Sakai, Toshiya Matsukawa, Takashi Yagi, Takao Naganuma, Masaru Mitsushima, Satoshi Iida, Yuka Inaba, Hiroshi Inoue, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-ichiro Asahara, Yoshiaki Kido, Shiro Minami, Masato Kasuga, Michihiro Matsumoto. PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes. Sci Rep 2018;8
    https://doi.org/10.1038/s41598-018-32575-z
  52. Kayley M. Usher, Sipin Zhu, Georgios Mavropalias, John A. Carrino, Jinmin Zhao, Jiake Xu. Pathological mechanisms and therapeutic outlooks for arthrofibrosis. Bone Res 2019;7
    https://doi.org/10.1038/s41413-019-0047-x
  53. Xinrong Geng, Kang Liu, Jinlei Wang, Xiangchen Su, Yijie Shi, Liang Zhao. Preparation of Ultra-Small Copper Nanoparticles-Loaded Self-Healing Hydrogels with Antibacterial, Inflammation-Suppressing and Angiogenesis-Enhancing Properties for Promoting Diabetic Wound Healing. IJN 2023;Volume 18:3339
    https://doi.org/10.2147/IJN.S399933
  54. Matilde Alique, Guillermo Bodega, Chiara Giannarelli, Julia Carracedo, Rafael Ramírez. MicroRNA-126 regulates Hypoxia-Inducible Factor-1α which inhibited migration, proliferation, and angiogenesis in replicative endothelial senescence. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-43689-3
  55. Tiantian Yan, Junhui Zhang, Di Tang, Xingyue Zhang, Xupin Jiang, Liping Zhao, Qiong Zhang, Dongxia Zhang, Yuesheng Huang, Cong Cao. Hypoxia Regulates mTORC1-Mediated Keratinocyte Motility and Migration via the AMPK Pathway. PLoS ONE 2017;12:e0169155
    https://doi.org/10.1371/journal.pone.0169155
  56. Bin Zhao, Hao Guan, Jia-Qi Liu, Zhao Zheng, Qin Zhou, Jian Zhang, Lin-Lin Su, Da-Hai Hu. Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway. 2017;39:153
    https://doi.org/10.3892/ijmm.2016.2816
  57. Jessica Salvo, Cristian Sandoval. Role of copper nanoparticles in wound healing for chronic wounds: literature review. 2022;10
    https://doi.org/10.1093/burnst/tkab047
  58. Aditya K. Kar, Amrita Singh, Divya Singh, Nikita Shraogi, Rahul Verma, Joel Saji, Pankaj Jagdale, Debabrata Ghosh, Satyakam Patnaik. Biopolymeric composite hydrogel loaded with silver NPs and epigallocatechin gallate (EGCG) effectively manages ROS for rapid wound healing in type II diabetic wounds. International Journal of Biological Macromolecules 2022;218:506
    https://doi.org/10.1016/j.ijbiomac.2022.06.196
  59. Jacqueline A. Maybin, Alison A. Murray, Philippa T. K. Saunders, Nikhil Hirani, Peter Carmeliet, Hilary O. D. Critchley. Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation. Nat Commun 2018;9
    https://doi.org/10.1038/s41467-017-02375-6
  60. Francesca Vitali, Simone Marini, Martina Balli, Hanne Grosemans, Maurilio Sampaolesi, Yves Lussier, Maria Cusella De Angelis, Riccardo Bellazzi. Exploring Wound-Healing Genomic Machinery with a Network-Based Approach. Pharmaceuticals 2017;10:55
    https://doi.org/10.3390/ph10020055
  61. Mario C. Manresa, Catherine Godson, Cormac T. Taylor. Hypoxia-sensitive pathways in inflammation-driven fibrosis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2014;307:R1369
    https://doi.org/10.1152/ajpregu.00349.2014
  62. Tingting Weng, Jialiang Wang, Min Yang, Wei Zhang, Pan Wu, Chuangang You, Chunmao Han, Xingang Wang. Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing. 2022;10
    https://doi.org/10.1093/burnst/tkab049
  63. Deju Lin, Liping Zhou, Biao Wang, Lizhen Liu, Li Cong, Chuanqin Hu, Tingting Ge, Qin Yu. Overexpression of HIF-1α in mesenchymal stem cells contributes to repairing hypoxic-ischemic brain damage in rats. Comptes Rendus Biologies 2017;340:18
    https://doi.org/10.1016/j.crvi.2016.11.001
  64. Fernando Ferreira, VijayKrishna Raghunathan, Guillaume Luxardi, Kan Zhu, Min Zhao. Early redox activities modulate Xenopus tail regeneration. Nat Commun 2018;9
    https://doi.org/10.1038/s41467-018-06614-2
  65. Coral García-Pastor, Selma Benito-Martínez, Victoria Moreno-Manzano, Ana B. Fernández-Martínez, Francisco Javier Lucio-Cazaña. Mechanism and Consequences of The Impaired Hif-1α Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-52310-6
  66. Tuathan O’Shea, Jeffrey Bamber, Davide Fontanarosa, Skadi van der Meer, Frank Verhaegen, Emma Harris. Review of ultrasound image guidance in external beam radiotherapy part II: intra-fraction motion management and novel applications. Phys. Med. Biol. 2016;61:R90
    https://doi.org/10.1088/0031-9155/61/8/R90
  67. Yanling Zhao, Xiao Ma, Jiabo Wang, Yun Zhu, Ruisheng Li, Jian Wang, Xuan He, Limei Shan, Ruilin Wang, Lifu Wang, Yonggang Li, Xiaohe Xiao. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway. Fitoterapia 2014;99:318
    https://doi.org/10.1016/j.fitote.2014.10.009
  68. Quan Li, Yuyu Xie, Zhangbo Cui, Hai Huang, Chengqing Yang, Baodong Yuan, Pei Shen, Chunwei Shi. Activation of hypoxia-inducible factor 1 (Hif-1) enhanced bactericidal effects of macrophages to Mycobacterium tuberculosis. Tuberculosis 2021;126:102044
    https://doi.org/10.1016/j.tube.2020.102044
  69. Ranieri Cancedda, Maddalena Mastrogiacomo. Transit Amplifying Cells (TACs): a still not fully understood cell population. Front. Bioeng. Biotechnol. 2023;11
    https://doi.org/10.3389/fbioe.2023.1189225
  70. Rou Wan, Joshua P. Weissman, Kendra Grundman, Lin Lang, Damian J. Grybowski, Robert D. Galiano. Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments. Wound Repair Regeneration 2021;29:573
    https://doi.org/10.1111/wrr.12954
  71. Sivakamasundari Pichu, Selvaraj Vimalraj, Jayalalitha Sathiyamoorthy, Vijay Viswanathan. Association of hypoxia inducible factor-1 alpha exon 12 mutation in diabetic patients with and without diabetic foot ulcer. International Journal of Biological Macromolecules 2018;119:833
    https://doi.org/10.1016/j.ijbiomac.2018.08.011
  72. Miriam I. du Plessis, Patrick S. Cottler, Chris A. Campbell. Acellular Dermal Matrix Favorably Modulates the Healing Response after Surgery. 2022;150:290e
    https://doi.org/10.1097/PRS.0000000000009338
  73. E.A. Kirasirova, E.A. Frolkina, I.E. Rybalchenko, S.I. Tyutina. Chronic respiratory failure correction in cicatricial laryngeal and tracheal stenosis using helium-oxygen mixture. Vestn. otorinolaringol. 2022;87:63
    https://doi.org/10.17116/otorino20228704163
  74. Yunsook Lim, Heaji Lee, Brittany Woodby, Giuseppe Valacchi. Ozonated Oils and Cutaneous Wound Healing. CPD 2019;25:2264
    https://doi.org/10.2174/1381612825666190702100504
  75. Walter Gottlieb Land. Damage-Associated Molecular Patterns in Human Diseases. 2019.
    https://doi.org/10.1007/978-3-030-53868-2_11
  76. Bin Wang, Huanhuan Wang, Mengmeng Zhang, Rui Ji, Jinlong Wei, Ying Xin, Xin Jiang. Radiation‐induced myocardial fibrosis: Mechanisms underlying its pathogenesis and therapeutic strategies. J Cellular Molecular Medi 2020;24:7717
    https://doi.org/10.1111/jcmm.15479
  77. Brian T. David, Jessica J. Curtin, David C. Goldberg, Kerri Scorpio, Veena Kandaswamy, Caitlin E. Hill. Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord. eNeuro 2020;7:ENEURO.0092-19.2019
    https://doi.org/10.1523/ENEURO.0092-19.2019
  78. Que Bai, Qian Gao, Fangfang Hu, Caiyun Zheng, Na Sun, Wenting Chen, Jinxi Liu, Yanni Zhang, Xianglong Wu, Tingli Lu. Reoxygenation Modulates the Adverse Effects of Hypoxia on Wound Repair. IJMS 2022;23:15832
    https://doi.org/10.3390/ijms232415832
  79. Jing Geng, Xiaoxi Huang, Ying Li, Xuefeng Xu, Shuhong Li, Dingyuan Jiang, Jiurong Liang, Dianhua Jiang, Chen Wang, Huaping Dai. Down-regulation of USP13 mediates phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis. Respir Res 2015;16
    https://doi.org/10.1186/s12931-015-0286-3
  80. Michael S. Valerio, Naveena B. Janakiram, Stephen M. Goldman, Christopher L. Dearth. Pleiotropic actions of Vitamin D in composite musculoskeletal trauma. Injury 2020;51:2099
    https://doi.org/10.1016/j.injury.2020.06.023
  81. Sergio A. Jimenez, Sonsoles Piera-Velazquez. Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?. Matrix Biology 2016;51:26
    https://doi.org/10.1016/j.matbio.2016.01.012
  82. Marc Bohner, Yassine Maazouz, Maria-Pau Ginebra, Pamela Habibovic, Jonathan Schoenecker, Howard Seeherman, Jeroen J.J.P. van den Beucken, Frank Witte. Sustained Local Ionic Homeostatic Imbalance (SLIHI) Caused by Calcification Modulates Inflammation to Trigger Ectopic Bone Formation. SSRN Journal 2021
    https://doi.org/10.2139/ssrn.3986891
  83. Barbara Gawronska-Kozak, Katarzyna Walendzik, Sylwia Machcinska, Artur Padzik, Marta Kopcewicz, Joanna Wiśniewska. Dermal White Adipose Tissue (dWAT) Is Regulated by Foxn1 and Hif-1α during the Early Phase of Skin Wound Healing. IJMS 2021;23:257
    https://doi.org/10.3390/ijms23010257
  84. Marc Bohner, Yassine Maazouz, Maria-Pau Ginebra, Pamela Habibovic, Jonathan G. Schoenecker, Howard Seeherman, Jeroen J.J.P. van den Beucken, Frank Witte. Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification. Acta Biomaterialia 2022;145:1
    https://doi.org/10.1016/j.actbio.2022.03.057
  85. L. R. Krinichko, K. P. Lokes, S. O. Stavitsky, S. �. Grigorov, L. I. Voloshina. DETERMINATION OF BREAKDOWN OF PRODUCTION OF ACTIVE FORMS OF OXYGEN AND CONTENT OF LIPIDS HYDROPEROXIDES IN HOMOGENATES OF CICATRICAL TISSUES IN DIFFERENT TERMS OF POSTALOPERATIVE PERIOD. VPBM 2018;4:95
    https://doi.org/10.29254/2077-4214-2018-4-1-146-95-98
  86. Huiqun Hu, Danni Zhong, Wanlin Li, Xiuhui Lin, Jian He, Yuchao Sun, Yuan Wu, Minqi Shi, Xiaoyuan Chen, Feng Xu, Min Zhou. Microalgae-based bioactive hydrogel loaded with quorum sensing inhibitor promotes infected wound healing. Nano Today 2022;42:101368
    https://doi.org/10.1016/j.nantod.2021.101368
  87. Yue Zhang, Fei Han, Lan Gu, Peng Ji, Xuekang Yang, Mengdong Liu, Kao Tao, Dahai Hu. Adipose mesenchymal stem cell exosomes promote wound healing through accelerated keratinocyte migration and proliferation by activating the AKT/HIF-1α axis. J Mol Hist 2020;51:375
    https://doi.org/10.1007/s10735-020-09887-4
  88. Yejin Park, Erang Im. Postpartum Gynetresia. Perinatology 2019;30:36
    https://doi.org/10.14734/PN.2019.30.1.36
  89. Mohamed Emam, Albert Caballero-Solares, Xi Xue, Navaneethaiyer Umasuthan, Barry Milligan, Richard G. Taylor, Rachel Balder, Matthew L. Rise. Gill and Liver Transcript Expression Changes Associated With Gill Damage in Atlantic Salmon (Salmo salar). Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.806484
  90. Zheng Li, Jiangbo Song, Jianfei Zhang, Kaige Hao, Lian Liu, Baiqing Wu, Xinyue Zheng, Bo Xiao, Xiaoling Tong, Fangyin Dai. Topical application of silk fibroin-based hydrogel in preventing hypertrophic scars. Colloids and Surfaces B: Biointerfaces 2020;186:110735
    https://doi.org/10.1016/j.colsurfb.2019.110735
  91. Shubhangi Agarwal, Praveen K. Gulaka, Ujjawal Rastogi, Vikram D. Kodibagkar. More bullets for PISTOL: linear and cyclic siloxane reporter probes for quantitative 1H MR oximetry. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-57889-9
  92. Yen‐Jen Wang, Xiao‐Feng Yao, Yang‐Sheng Lin, Jen‐Yu Wang, Chang‐Cheng Chang. Oncologic feasibility for negative pressure wound therapy application in surgical wounds: A meta‐analysis. International Wound Journal 2022;19:573
    https://doi.org/10.1111/iwj.13654
  93. Junhui Zhang, Can Zhang, Xupin Jiang, Lingfei Li, Dongxia Zhang, Di Tang, Tiantian Yan, Qiong Zhang, Hongping Yuan, Jiezhi Jia, Jiongyu Hu, Jiaping Zhang, Yuesheng Huang. Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration. Cell Death Dis 2019;10
    https://doi.org/10.1038/s41419-019-1473-9
  94. Victoria Pulido-Escribano, Bárbara Torrecillas-Baena, Marta Camacho-Cardenosa, Gabriel Dorado, María Ángeles Gálvez-Moreno, Antonio Casado-Díaz. Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles. WJSC 2022;14:453
    https://doi.org/10.4252/wjsc.v14.i7.453
  95. Jian-Rong Guo, Lei Yin, Yong-Quan Chen, Xiao-Ju Jin, Xun Zhou, Na-Na Zhu, Xiao-Qian Liu, Han-Wei Wei, Li-Shuang Duan. Autologous blood transfusion augments impaired wound healing in diabetic mice by enhancing lncRNA H19 expression via the HIF-1α signaling pathway. Cell Commun Signal 2018;16
    https://doi.org/10.1186/s12964-018-0290-6
  96. Simona Simmen, Max Maane, Sarah Rogler, Katherina Baebler, Silvia Lang, Jesus Cosin-Roger, Kirstin Atrott, Isabelle Frey-Wagner, Partick Spielmann, Roland H. Wenger, Bruce Weder, Jonas Zeitz, Stephan R. Vavricka, Gerhard Rogler, Cheryl de Vallière, Martin Hausmann, Pedro A. Ruiz. Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa. Inflamm Intest Dis 2021;6:87
    https://doi.org/10.1159/000513061
  97. G. E. Sheiko, M. N. Kudykin, V. V. Beschastnov, M. G. Ryabkov, R. A. Deryabin, A. N. Vasjagin, A. N. Belova. Level change features of a hypoxia-induced factor 1α in patients with critical lower limb ischemia. Regional blood circulation and microcirculation 2018;17:102
    https://doi.org/10.24884/1682-6655-2018-17-3-102-106
  98. Elena Hofmann, Josefin Soppert, Tim Ruhl, Epameinondas Gousopoulos, Simona Gerra, Gabriele Storti, Yuan Tian, Markus Brandhofer, Riccardo Schweizer, Seung-Yong Song, Nicole Lindenblatt, Norbert Pallua, Jürgen Bernhagen, Bong-Sung Kim. The Role of Macrophage Migration Inhibitory Factor in Adipose-Derived Stem Cells Under Hypoxia. Front. Physiol. 2021;12
    https://doi.org/10.3389/fphys.2021.638448
  99. Sylwia Machcinska, Marta Kopcewicz, Joanna Bukowska, Katarzyna Walendzik, Barbara Gawronska‐Kozak. Impairment of the Hif‐1α regulatory pathway in Foxn1‐deficient (Foxn1 −/− ) mice affects the skin wound healing process . FASEB j. 2021;35
    https://doi.org/10.1096/fj.202001907R
  100. Mohit Sharma, Raghu Radhakrishnan. Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies. J Oral Pathol Med 2017;46:424
    https://doi.org/10.1111/jop.12513
  101. Di Tang, Tiantian Yan, Junhui Zhang, Xupin Jiang, Dongxia Zhang, Yuesheng Huang. Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration. Sci Rep 2017;7
    https://doi.org/10.1038/srep43926
  102. Junhui Zhang, Dongxia Zhang, Tiantian Yan, Xupin Jiang, Can Zhang, Liping Zhao, Lingfei Li, Di Tang, Qiong Zhang, Jiezhi Jia, Jiaping Zhang, Yuesheng Huang. BNIP3 promotes the motility and migration of keratinocyte under hypoxia. Experimental Dermatology 2017;26:416
    https://doi.org/10.1111/exd.13248
  103. Rahima Begum, A. N. M. Mamun-Or-Rashid, Tanzima Tarannum Lucy, Md. Kamruzzaman Pramanik, Bijon Kumar Sil, Nobendu Mukerjee, Priti Tagde, Masayuki Yagi, Yoshikazu Yonei. Potential Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2. Molecules 2022;27:6934
    https://doi.org/10.3390/molecules27206934
  104. Irina Raykhel, Fazeh Moafi, Satu M. Myllymäki, Patricia G. Greciano, Karl S. Matlin, Jose V. Moyano, Aki Manninen, Johanna Myllyharju. BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity in hypoxia. 2018
    https://doi.org/10.1242/jcs.210906
  105. Xi Qin, Keling Wu, Chengguo Zuo, Mingkai Lin. The Expression and Role of Hypoxia-induced Factor-1α in Human Tenon’s Capsule Fibroblasts under Hypoxia. Current Eye Research 2021;46:417
    https://doi.org/10.1080/02713683.2020.1805470
  106. Violaine Sironval, Laurence Reylandt, Perrine Chaurand, Saloua Ibouraadaten, Mihaly Palmai-Pallag, Yousof Yakoub, Bernard Ucakar, Jérôme Rose, Claude Poleunis, Rita Vanbever, Etienne Marbaix, Dominique Lison, Sybille van den Brule. Respiratory hazard of Li-ion battery components: elective toxicity of lithium cobalt oxide (LiCoO2) particles in a mouse bioassay. Arch Toxicol 2018;92:1673
    https://doi.org/10.1007/s00204-018-2188-x
  107. Yan Li, Juan Wang, Yan Wang, Wenguo Cui. Advanced electrospun hydrogel fibers for wound healing. Composites Part B: Engineering 2021;223:109101
    https://doi.org/10.1016/j.compositesb.2021.109101
  108. Takahiro Manabe, Heamin Park, Takashi Minami. Calcineurin-nuclear factor for activated T cells (NFAT) signaling in pathophysiology of wound healing. Inflamm Regener 2021;41
    https://doi.org/10.1186/s41232-021-00176-5
  109. Rashid Mir, Imadeldin Elfaki, Ajaz Ahmad Waza, Faisel M. AbuDuhier. Diabetic Foot Ulcer. 2021.
    https://doi.org/10.1007/978-981-15-7639-3_16
  110. Ryan F.L. O'Shaughnessy, Sara J. Brown. Insight from the Air–Skin Interface. Journal of Investigative Dermatology 2015;135:331
    https://doi.org/10.1038/jid.2014.457
  111. Lara Stolzenburg-Veeser, Olga Golubnitschaja. Mini-encyclopaedia of the wound healing - Opportunities for integrating multi-omic approaches into medical practice. Journal of Proteomics 2018;188:71
    https://doi.org/10.1016/j.jprot.2017.07.017
  112. Le Kuai, Jing‐Si Jiang, Wei Li, Bin Li, Shuang‐Yi Yin. Long non‐coding RNAs in diabetic wound healing: Current research and clinical relevance. International Wound Journal 2022;19:583
    https://doi.org/10.1111/iwj.13655
  113. Alireza Hassanshahi, Mohammad Moradzad, Saman Ghalamkari, Moosa Fadaei, Allison J. Cowin, Mohammadhossein Hassanshahi. Macrophage-Mediated Inflammation in Skin Wound Healing. Cells 2022;11:2953
    https://doi.org/10.3390/cells11192953
  114. Sophie Bachmann, Martina Jennewein, Monika Bubel, Silke Guthörl, Tim Pohlemann, Martin Oberringer. Interacting adipose-derived stem cells and microvascular endothelial cells provide a beneficial milieu for soft tissue healing. Mol Biol Rep 2020;47:111
    https://doi.org/10.1007/s11033-019-05112-y
  115. Deepshikha Sharma, Preeti Singh, Surya S. Singh. β-N-oxalyl-L-α,β-diaminopropionic acid induces wound healing by stabilizing HIF-1α and modulating associated protein expression. Phytomedicine 2018;44:9
    https://doi.org/10.1016/j.phymed.2018.04.024
  116. Esha Madan, Taylor M Parker, Christopher J Pelham, Antonio M Palma, Maria L Peixoto, Masaki Nagane, Aliya Chandaria, Ana R Tomás, Rita Canas-Marques, Vanessa Henriques, Antonio Galzerano, Joaquim Cabral-Teixeira, Karuppaiyah Selvendiran, Periannan Kuppusamy, Carlos Carvalho, Antonio Beltran, Eduardo Moreno, Uttam K Pati, Rajan Gogna. HIF-transcribed p53 chaperones HIF-1α. 2019;47:10212
    https://doi.org/10.1093/nar/gkz766
  117. So Kim, Eun Yang. Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications. Molecules 2015;20:20551
    https://doi.org/10.3390/molecules201119717
  118. Zhijie Fan, Motuma Yigezu Daba, Lingyan Xiao, Xianglin Yuan. Role of miRNA-21 in radiation-induced heart disease. 2023;9:56
    https://doi.org/10.1007/s10330-023-0625-5
  119. Seth Andrews, Ty Maughon, Ross Marklein, Steven Stice. Priming of MSCs with inflammation-relevant signals affects extracellular vesicle biogenesis, surface markers, and modulation of T cell subsets. Journal of Immunology and Regenerative Medicine 2021;13:100036
    https://doi.org/10.1016/j.regen.2020.100036
  120. Danni Zhong, Zhen Du, Min Zhou. Algae: A natural active material for biomedical applications. VIEW 2021;2
    https://doi.org/10.1002/VIW.20200189
  121. Kevin Schilling, Mirna El Khatib, Shane Plunkett, Jiajia Xue, Younan Xia, Sergei A. Vinogradov, Edward Brown, Xinping Zhang. Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair. ACS Appl. Mater. Interfaces 2019;11:33548
    https://doi.org/10.1021/acsami.9b08341
  122. Marta Gómez-Ferrer, Elena Amaro-Prellezo, Akaitz Dorronsoro, Rafael Sánchez-Sánchez, Ángeles Vicente, Jesús Cosín-Roger, María Dolores Barrachina, María Carmen Baquero, Jaris Valencia, Pilar Sepúlveda. HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn’s Disease. IJMS 2021;22:11269
    https://doi.org/10.3390/ijms222011269
  123. Yuko Hara-Saito, Hiroko Kato, Naoaki Saito, Aki Shiomi, Atsushi Uenoyama, Ritsuo Takagi, Kenji Izumi. Distinct differences in hypoxic responses between human oral mucosa and skin fibroblasts in a 3D collagen matrix. In Vitro Cell.Dev.Biol.-Animal 2020;56:452
    https://doi.org/10.1007/s11626-020-00458-1
  124. Wanlin Li, Shoujie Wang, Danni Zhong, Zhen Du, Min Zhou. A Bioactive Living Hydrogel: Photosynthetic Bacteria Mediated Hypoxia Elimination and Bacteria‐Killing to Promote Infected Wound Healing. Advanced Therapeutics 2021;4
    https://doi.org/10.1002/adtp.202000107
  125. Katie M. Hamel, Kara Q. Liimatta, Jorge A. Belgodere, Bruce A. Bunnell, Jeffrey M. Gimble, Elizabeth C. Martin. Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds: Evaluation of Patient Age. Stem Cells and Development 2022;31:579
    https://doi.org/10.1089/scd.2021.0280
  126. Carolini Mendes, Anand Thirupathi, Maria E. A. B. Corrêa, Yaodong Gu, Paulo C. L. Silveira. The Use of Metallic Nanoparticles in Wound Healing: New Perspectives. IJMS 2022;23:15376
    https://doi.org/10.3390/ijms232315376
  127. Marlene Sophia Kohlhepp, Hanyang Liu, Frank Tacke, Adrien Guillot. The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities. Front. Mol. Biosci. 2023;10
    https://doi.org/10.3389/fmolb.2023.1129831
  128. Amina Khadjavi, Chiara Magnetto, Alice Panariti, Monica Argenziano, Giulia Rossana Gulino, Ilaria Rivolta, Roberta Cavalli, Giuliana Giribaldi, Caterina Guiot, Mauro Prato. Chitosan-shelled oxygen-loaded nanodroplets abrogate hypoxia dysregulation of human keratinocyte gelatinases and inhibitors: New insights for chronic wound healing. Toxicology and Applied Pharmacology 2015;286:198
    https://doi.org/10.1016/j.taap.2015.04.015
  129. Mehrnaz Mehrabani, Mojdeh Esmaeili-Tarzi, Hamid Forootanfar, Mohammad Hadi Nematollahi, Ibrahim M. Banat, Mandana Ohadi, Gholamreza Dehghannoudeh. Lipopeptide Biosurfactant from Acinetobacter junii B6: A Promising Natural Surfactant for Promoting Angiogenesis. Int J Pept Res Ther 2021;27:1197
    https://doi.org/10.1007/s10989-021-10160-9
  130. Eyal Melamed, Patrick Kiambi, Dancan Okoth, Irena Honigber, Eran Tamir, Gadi Borkow. Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series. Medicina 2021;57:296
    https://doi.org/10.3390/medicina57030296