Molecules and Cells

Cited by CrossRef (256)

  1. Laura L. Gonzalez, Karin Garrie, Mark D. Turner. Type 2 diabetes – An autoinflammatory disease driven by metabolic stress. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018;1864:3805
    https://doi.org/10.1016/j.bbadis.2018.08.034
  2. Jaehyeon Hwang, Ju Ah Yoo, Hyungkee Yoon, Taekyung Han, Jongchan Yoon, Seoljun An, Jae Youl Cho, Jongsung Lee. The Role of Leptin in the Association between Obesity and Psoriasis. Biomolecules & Therapeutics 2021;29:11
    https://doi.org/10.4062/biomolther.2020.054
  3. Leena P. Bharath, Blanche C. Ip, Barbara S. Nikolajczyk. Comprehensive Physiology. 2021.
    https://doi.org/10.1002/cphy.c160042
  4. Tadeu P. D. Oliveira, Bruno D. C. Gonçalves, Bruna S. Oliveira, Antonio Carlos P. de Oliveira, Helton J. Reis, Claudia N. Ferreira, Daniele C. Aguiar, Aline S. de Miranda, Fabiola M. Ribeiro, Erica M. L. Vieira, András Palotás, Luciene B. Vieira. Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior. Front. Neurosci. 2021;15
    https://doi.org/10.3389/fnins.2021.631311
  5. Tae Woo Jung, Yoon Hee Chung, Hyoung-Chun Kim, A. M. Abd El-Aty, Ji Hoon Jeong. Protectin DX attenuates LPS-induced inflammation and insulin resistance in adipocytes via AMPK-mediated suppression of the NF-κB pathway. American Journal of Physiology-Endocrinology and Metabolism 2018;315:E543
    https://doi.org/10.1152/ajpendo.00408.2017
  6. Yoon Jeong Park, Sang Mun Han, Jin Young Huh, Jae Bum Kim. Emerging roles of epigenetic regulation in obesity and metabolic disease. Journal of Biological Chemistry 2021;297:101296
    https://doi.org/10.1016/j.jbc.2021.101296
  7. Masuko Kobori, Yukari Akimoto, Yumiko Takahashi, Toshiyuki Kimura. Combined Effect of Quercetin and Fish Oil on Oxidative Stress in the Liver of Mice Fed a Western-Style Diet. J. Agric. Food Chem. 2020;68:13267
    https://doi.org/10.1021/acs.jafc.0c02984
  8. Mayara Belchior‐Bezerra, Rafael Silva Lima, Nayara I. Medeiros, Juliana A. S. Gomes. COVID‐19, obesity, and immune response 2 years after the pandemic: A timeline of scientific advances. Obesity Reviews 2022;23
    https://doi.org/10.1111/obr.13496
  9. Wen-Yu Hsiao, David A. Guertin. De Novo Lipogenesis as a Source of Second Messengers in Adipocytes. Curr Diab Rep 2019;19
    https://doi.org/10.1007/s11892-019-1264-9
  10. Muddassar Hameed, Elizabeth Geerling, Amelia K. Pinto, Iqra Miraj, James Weger-Lucarelli. Immune response to arbovirus infection in obesity. Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.968582
  11. Arturo Roca-Rivada, Susana Belen Bravo, Diego Pérez-Sotelo, Jana Alonso, Ana Isabel Castro, Iván Baamonde, Javier Baltar, Felipe F. Casanueva, María Pardo. CILAIR-Based Secretome Analysis of Obese Visceral and Subcutaneous Adipose Tissues Reveals Distinctive ECM Remodeling and Inflammation Mediators. Sci Rep 2015;5
    https://doi.org/10.1038/srep12214
  12. Maira Hameed, Stuart A Taylor. Small bowel imaging in inflammatory bowel disease: updates for 2023. Expert Review of Gastroenterology & Hepatology 2023;17:1117
    https://doi.org/10.1080/17474124.2023.2274926
  13. Beatriz Assis Carvalho Cruvinel, Ana Gabriella Pereira Alves, Raquel Machado Schincaglia, Maria Sebastiana Silva. Baru nuts reduce abdominal adiposity in type 2 diabetic adults: a randomized, placebo-controlled, crossover trial. Rev. Nutr. 2023;36
    https://doi.org/10.1590/1678-9865202336e220103
  14. Xiaopeng Li, Jiayi Zhou, Min Fang, Bolan Yu. Pregnancy immune tolerance at the maternal-fetal interface. International Reviews of Immunology 2020;39:247
    https://doi.org/10.1080/08830185.2020.1777292
  15. Yazan Alwarawrah, Nancie J. MacIver. Pediatric Obesity. 2020.
    https://doi.org/10.1007/978-3-319-68192-4_22
  16. Patricia Corrales, Antonio Vidal-Puig, Gema Medina-Gómez. PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity. IJMS 2018;19:2124
    https://doi.org/10.3390/ijms19072124
  17. Sabrina Eliana Gambaro, María Guillermina Zubiría, Alejandra Paula Giordano, Andrea Estefanía Portales, Ana Alzamendi, Martín Rumbo, Andrés Giovambattista. “Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice”. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2020;1865:158700
    https://doi.org/10.1016/j.bbalip.2020.158700
  18. Patricia Corrales, Yurena Vivas, Adriana Izquierdo‐Lahuerta, Daniel Horrillo, Patricia Seoane‐Collazo, Ismael Velasco, Lucia Torres, Yamila Lopez, Carmen Martínez, Miguel López, Manuel Ros, Maria Jesus Obregon, Gema Medina‐Gomez. Long‐term caloric restriction ameliorates deleterious effects of aging on white and brown adipose tissue plasticity. Aging Cell 2019;18
    https://doi.org/10.1111/acel.12948
  19. Jin Young Huh, Yoon Jeong Park, Jae Bum Kim. Adipocyte CD1d determines adipose inflammation and insulin resistance in obesity. Adipocyte 2018:1
    https://doi.org/10.1080/21623945.2018.1440928
  20. Akm Khyrul Wara, Shijia Wang, Chun Wu, Fang Fang, Stefan Haemmig, Brittany N. Weber, Ceren O. Aydogan, Yevgenia Tesmenitsky, Hassan Aliakbarian, John R. Hawse, Malayannan Subramaniam, Lei Zhao, Peter T. Sage, Ali Tavakkoli, Amanda Garza, Lydia Lynch, Alexander S. Banks, Mark W. Feinberg. KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver. Cell Reports 2020;33:108550
    https://doi.org/10.1016/j.celrep.2020.108550
  21. Jin Young Huh, Jeu Park, Jong In Kim, Yoon Jeong Park, Yun Kyung Lee, Jae Bum Kim. Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity. 2017;66:835
    https://doi.org/10.2337/db16-1122
  22. Anastasia Ponasenko, Maxim Sinitsky, Varvara Minina, Anna Vesnina, Maria Khutornaya, Alexander Prosekov, Olga Barbarash. Immune Response and Lipid Metabolism Gene Polymorphisms Are Associated with the Risk of Obesity in Middle-Aged and Elderly Patients. JPM 2022;12:238
    https://doi.org/10.3390/jpm12020238
  23. Sandeep Sundara Rajan, Maria Paula Longhi. Dendritic cells and adipose tissue. Immunology 2016;149:353
    https://doi.org/10.1111/imm.12653
  24. Amy Christensen, Jiahui Liu, Christian J. Pike. Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice. Front. Aging Neurosci. 2020;12
    https://doi.org/10.3389/fnagi.2020.00113
  25. Abdullah Omar, Tapan K. Chatterjee, Yaoliang Tang, David Y. Hui, Neal L. Weintraub. Proinflammatory Phenotype of Perivascular Adipocytes. ATVB 2014;34:1631
    https://doi.org/10.1161/ATVBAHA.114.303030
  26. Tiantian Wang. Searching for the link between inflammaging and sarcopenia. Ageing Research Reviews 2022;77:101611
    https://doi.org/10.1016/j.arr.2022.101611
  27. Cécile Martinerie, Marie Garcia, Thi Thu Huong Do, Bénédicte Antoine, Marthe Moldes, Guillaume Dorothee, Chantal Kazazian, Martine Auclair, Marion Buyse, Tatiana Ledent, Pierre-Olivier Marchal, Maria Fesatidou, Adrien Beisseiche, Haruhiko Koseki, Shuichi Hiraoka, Christos Evangelos Chadjichristos, Bertrand Blondeau, Raphael Georges Denis, Serge Luquet, Bruno Fève. NOV/CCN3: A New Adipocytokine Involved in Obesity-Associated Insulin Resistance. 2016;65:2502
    https://doi.org/10.2337/db15-0617
  28. Chong-Hyun Shin, Ki-Hye Kim, Subbiah Jeeva, Sang-Moo Kang. Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome. Cells 2021;10:1412
    https://doi.org/10.3390/cells10061412
  29. Jeanet Serafín López, Ursino Pacheco García, María Eugenia Castro Mussot, Ernesto Pacheco Ramírez. Phagocytosis - Main Key of Immune System. 2021.
    https://doi.org/10.5772/intechopen.110510
  30. Jonathan M. Nizar, Vivek Bhalla. Molecular Mechanisms of Sodium-Sensitive Hypertension in the Metabolic Syndrome. Curr Hypertens Rep 2017;19
    https://doi.org/10.1007/s11906-017-0759-5
  31. B C S Boa, J S Yudkin, V W M van Hinsbergh, E Bouskela, E C Eringa. Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function. British J Pharmacology 2017;174:3466
    https://doi.org/10.1111/bph.13732
  32. Zsuzsanna Suba. Understanding the Molecular Crosstalk in Biological Processes. 2017.
    https://doi.org/10.5772/intechopen.85995
  33. Martin Klein, Ivan Varga. Microenvironment of Immune Cells Within the Visceral Adipose Tissue Sensu Lato vs. Epicardial Adipose Tissue: What Do We Know?. Inflammation 2018;41:1142
    https://doi.org/10.1007/s10753-018-0798-3
  34. Lok Yan Joanne Cheng, Tai Hong Andrew Lung, Shu Yan Ng. Facial Nerve Palsy - A Practitioner’s Guide. 2018.
    https://doi.org/10.5772/intechopen.106617
  35. Liang Xu, Dandan Li, Yuqin Zhu, Suili Cai, Xue Liang, Ying Tang, Shengnan Jin, Chunming Ding. Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet. Adipocyte 2021;10:160
    https://doi.org/10.1080/21623945.2021.1906510
  36. Eduard T. Ambarchyan, Leila S. Namazova-Baranova, Nikolay N. Murashkin, Elena A. Vishneva, Grigoriy V. Revunenkov, Natalya G. Ovsyanik, Vladislav V. Ivanchikov, Anastasia D. Kuzminova. Leptin and Epicardial Fat: New Markers of Psoriasis in Children? Prospective Cross-Sectional Study. Pediatr. farmakol. 2022;19:242
    https://doi.org/10.15690/pf.v19i3.2481
  37. Hafiz Muhammad Ahmad Javaid, Namood E Sahar, De-Li ZhuGe, Joo Young Huh. Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like. Cells 2021;10:3480
    https://doi.org/10.3390/cells10123480
  38. Ivan J. Vechetti, Bailey D. Peck, Yuan Wen, R. Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand von Walden, Björn Alkner, Charlotte A. Peterson, John J. McCarthy. Mechanical overload‐induced muscle‐derived extracellular vesicles promote adipose tissue lipolysis. The FASEB Journal 2021;35
    https://doi.org/10.1096/fj.202100242R
  39. Aleida Núñez Ruiz, Juan Diego Cortés-Garcia, Nancy Cortez-Espinosa, Paola Indira Herrera-Rojas, Víctor Manuel Ruíz-Rodríguez, Mariana Salgado-Bustamante, Mariana Haydee García-Hernández, Elizabeth Reynaga-Hernández, Veronica del Carmen Martínez-Jimenez, Diana Patricia Portales-Pérez. Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects. Nutrition 2016;32:943
    https://doi.org/10.1016/j.nut.2016.02.006
  40. Konstanze Zieger, Juliane Weiner, Kerstin Krause, Maximilian Schwarz, Martin Kohn, Michael Stumvoll, Matthias Blüher, John T. Heiker. Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway. Molecular and Cellular Endocrinology 2018;460:181
    https://doi.org/10.1016/j.mce.2017.07.022
  41. L. H. Wijngaarden, A. E. Taselaar, F. Nuijten, E. van der Harst, R. A. Klaassen, T. M. Kuijper, F. Jongbloed, G. Ambagtsheer, M. Klepper, J. N. M. IJzermans, R. W. F. de Bruin, N. H. R. Litjens. T and B Cell Composition and Cytokine Producing Capacity Before and After Bariatric Surgery. Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.888278
  42. Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjão, Rosemari Otton. Green tea beneficial effects involve changes in the profile of immune cells in the adipose tissue of obese mice. Eur J Nutr 2023;62:321
    https://doi.org/10.1007/s00394-022-02963-3
  43. Chileka Chiyanika, Lorena Tsui Fun Cheung, Kin Hung Liu, Alice Pik Shan Kong, Simon Kin Hung Wong, Enders Kwok Wai Ng, Winnie Chiu Wing Chu. Changes in mesenteric fat thickness and its clinical impact in bariatric surgery. Clinical Obesity 2023
    https://doi.org/10.1111/cob.12627
  44. Savita Bansal, Meenakshi Vachher, Taruna Arora, Bhupender Kumar, Archana Burman. Visceral fat: A key mediator of NAFLD development and progression. Human Nutrition & Metabolism 2023;33:200210
    https://doi.org/10.1016/j.hnm.2023.200210
  45. Kendall P. Murphy, Michael A. Hendley, Christopher Isely, Prakasam Annamalai, Edsel Peña, R. Michael Gower. Resveratrol Delivery from Porous Poly(lactide-co-glycolide) Scaffolds Promotes an Anti-Inflammatory Environment within Visceral Adipose Tissue. ACS Appl. Mater. Interfaces 2018;10:43363
    https://doi.org/10.1021/acsami.8b13421
  46. Vanessa A. Guerreiro, Davide Carvalho, Paula Freitas, Nunzio Velotti. Obesity, Adipose Tissue, and Inflammation Answered in Questions. Journal of Obesity 2022;2022:1
    https://doi.org/10.1155/2022/2252516
  47. Jensen N. Amens, Gökhan Bahçecioğlu, Kiera Dwyer, Xiaoshan S. Yue, M. Sharon Stack, Tyvette S. Hilliard, Pinar Zorlutuna. Maternal obesity driven changes in collagen linearity of breast extracellular matrix induces invasive mammary epithelial cell phenotype. Biomaterials 2023;297:122110
    https://doi.org/10.1016/j.biomaterials.2023.122110
  48. Sebastian Mukka, Ola Rolfson, Maziar Mohaddes, Arkan Sayed-Noor. The Effect of Body Mass Index Class on Patient-Reported Health-Related Quality of Life Before and After Total Hip Arthroplasty for Osteoarthritis. 2020;5:e20.00100
    https://doi.org/10.2106/JBJS.OA.20.00100
  49. Xiao-Yan Qi, Shun-Lin Qu, Wen-Hao Xiong, Oren Rom, Lin Chang, Zhi-Sheng Jiang. Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword. Cardiovasc Diabetol 2018;17
    https://doi.org/10.1186/s12933-018-0777-x
  50. Sara J. Sidles, Ying Xiong, M. Rita I. Young, Amanda C. LaRue. High-Fat Diet Alters Immunogenic Properties of Circulating and Adipose Tissue-Associated Myeloid-Derived CD45+DDR2+ Cells. Mediators of Inflammation 2019;2019:1
    https://doi.org/10.1155/2019/1648614
  51. Paola de Candia, Francesco Prattichizzo, Silvia Garavelli, Veronica De Rosa, Mario Galgani, Francesca Di Rella, Maria Immacolata Spagnuolo, Alessandra Colamatteo, Clorinda Fusco, Teresa Micillo, Sara Bruzzaniti, Antonio Ceriello, Annibale A. Puca, Giuseppe Matarese. Type 2 Diabetes: How Much of an Autoimmune Disease?. Front. Endocrinol. 2019;10
    https://doi.org/10.3389/fendo.2019.00451
  52. Lu Wen, Rong Li, Ying-Cai Zhao, Jin-Yue Yang, Xiao-Yue Li, Chang-Hu Xue, Tian-Tian Zhang, Yu-Ming Wang. A Comparative Study of the Anti-Obesity Effects of Dietary Sea Cucumber Saponins and Energy Restriction in Response to Weight Loss and Weight Regain in Mice. Marine Drugs 2022;20:629
    https://doi.org/10.3390/md20100629
  53. Masanori Katsumura, Shoko Takagi, Hana Oya, Shohei Tamura, Takaoki Saneyasu, Kazuhisa Honda, Hiroshi Kamisoyama. Effects of dietary heme iron and exercise training on abdominal fat accumulation and lipid metabolism in high‐fat diet‐fed mice. Animal Science Journal 2017;88:1100
    https://doi.org/10.1111/asj.12734
  54. Connie W.Y. Ha, Anthony Martin, Gregory D. Sepich-Poore, Baochen Shi, Yizhou Wang, Kenneth Gouin, Gregory Humphrey, Karenina Sanders, Yasiru Ratnayake, Kelvin S.L. Chan, Gustaf Hendrick, J.R. Caldera, Christian Arias, Jacob E. Moskowitz, Shannan J. Ho Sui, Shaohong Yang, David Underhill, Matthew J. Brady, Simon Knott, Kelly Kaihara, Michael J. Steinbaugh, Huiying Li, Dermot P.B. McGovern, Rob Knight, Phillip Fleshner, Suzanne Devkota. Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans. Cell 2020;183:666
    https://doi.org/10.1016/j.cell.2020.09.009
  55. Ivan Dimauro, Elisa Grazioli, Cristina Antinozzi, Guglielmo Duranti, Alessia Arminio, Annamaria Mancini, Emanuela A. Greco, Daniela Caporossi, Attilio Parisi, Luigi Di Luigi. Estrogen-Receptor-Positive Breast Cancer in Postmenopausal Women: The Role of Body Composition and Physical Exercise. IJERPH 2021;18:9834
    https://doi.org/10.3390/ijerph18189834
  56. Hui Pan, Lin-Li Deng, Jia-Qi Cui, Lin Shi, Yi-Chun Yang, Jiang-Hui Luo, Dan Qin, Li Wang. Association between serum leptin levels and breast cancer risk. 2018;97:e11345
    https://doi.org/10.1097/MD.0000000000011345
  57. Ilija Jeftic, Marina Miletic-Kovacevic, Nemanja Jovicic, Jelena Pantic, Nebojsa Arsenijevic, Miodrag L. Lukic, Nada Pejnovic. Galectin-3 Deletion Enhances Visceral Adipose Tissue Inflammation and Dysregulates Glucose Metabolism in Mice on a High-Fat Diet. 2016;17:231
    https://doi.org/10.1515/sjecr-2016-0030
  58. M. Cabral, M. Severo, H. Barros, J.T. Guimarães, E. Ramos. Longitudinal association of adiposity and high-sensitivity C-reactive protein from adolescence into early adulthood. Nutrition, Metabolism and Cardiovascular Diseases 2019;29:590
    https://doi.org/10.1016/j.numecd.2019.03.008
  59. Lisa R. Hoving, Hendrik J. P. van der Zande, Amanda Pronk, Bruno Guigas, Ko Willems van Dijk, Vanessa van Harmelen, Brenda Smith. Dietary yeast-derived mannan oligosaccharides have immune-modulatory properties but do not improve high fat diet-induced obesity and glucose intolerance. PLoS ONE 2018;13:e0196165
    https://doi.org/10.1371/journal.pone.0196165
  60. Manuela Del Cornò, Rosaria Varì, Beatrice Scazzocchio, Barbara Varano, Roberta Masella, Lucia Conti. Dietary Fatty Acids at the Crossroad between Obesity and Colorectal Cancer: Fine Regulators of Adipose Tissue Homeostasis and Immune Response. Cells 2021;10:1738
    https://doi.org/10.3390/cells10071738
  61. Ahmed Bakillah, M. Mahmood Hussain. Mice subjected to aP2-Cre mediated ablation of microsomal triglyceride transfer protein are resistant to high fat diet induced obesity. Nutr Metab (Lond) 2016;13
    https://doi.org/10.1186/s12986-016-0061-6
  62. Gina Song, Oscar T. Suzuki, Charlene M. Santos, Andrew T. Lucas, Tim Wiltshire, William C. Zamboni. Gulp1 is associated with the pharmacokinetics of PEGylated liposomal doxorubicin (PLD) in inbred mouse strains. Nanomedicine: Nanotechnology, Biology and Medicine 2016;12:2007
    https://doi.org/10.1016/j.nano.2016.05.019
  63. Danyelle Liddle, Amber Hutchinson, Hannah Wellings, Krista Power, Lindsay Robinson, Jennifer Monk. Integrated Immunomodulatory Mechanisms through which Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate Obese Adipose Tissue Dysfunction. Nutrients 2017;9:1289
    https://doi.org/10.3390/nu9121289
  64. Kripa Shankar, Durgesh Kumar, Sanchita Gupta, Salil Varshney, Sujith Rajan, Ankita Srivastava, Abhishek Gupta, Anand Prakash Gupta, Achchhe Lal Vishwakarma, Jiaur R. Gayen, Anil Nilkanth Gaikwad. Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice. European Journal of Pharmacology 2019;854:354
    https://doi.org/10.1016/j.ejphar.2019.02.044
  65. Kaitlin Kiernan, Nancie J. MacIver. The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. Front. Immunol. 2021;11
    https://doi.org/10.3389/fimmu.2020.622468
  66. Liang Xu, Tsuguhito Ota. Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization. Adipocyte 2017:1
    https://doi.org/10.1080/21623945.2017.1413516
  67. Ying Huang, Yingzhong Lin, Shumin Zhang, Zhijian Wang, Jianwei Zhang, Chao Chang, Ling Liu, Qingwei Ji, Xiaofei Liu. Circulating Omentin-1 Levels Are Decreased in Dilated Cardiomyopathy Patients with Overt Heart Failure. Disease Markers 2016;2016:1
    https://doi.org/10.1155/2016/6762825
  68. J.C.J. van Esterik, H.W. Verharen, H.M. Hodemaekers, E.R. Gremmer, B. Nagarajah, J.H. Kamstra, M.E.T. Dollé, J. Legler, L.T.M. van der Ven. Compound- and sex-specific effects on programming of energy and immune homeostasis in adult C57BL/6JxFVB mice after perinatal TCDD and PCB 153. Toxicology and Applied Pharmacology 2015;289:262
    https://doi.org/10.1016/j.taap.2015.09.017
  69. Giulia Matacchione, Jessica Perugini, Eleonora Di Mercurio, Jacopo Sabbatinelli, Francesco Prattichizzo, Martina Senzacqua, Gianluca Storci, Christian Dani, Giovanni Lezoche, Mario Guerrieri, Antonio Giordano, Massimiliano Bonafè, Fabiola Olivieri. Senescent macrophages in the human adipose tissue as a source of inflammaging. GeroScience 2022;44:1941
    https://doi.org/10.1007/s11357-022-00536-0
  70. Jing Li, Yu-Shan Mao, Fen Chen, Dong-Xia Xia, Tin-Qi Zhao. Palmitic acid up regulates Gal‑3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF‑κB. Exp Ther Med 2021;22
    https://doi.org/10.3892/etm.2021.10460
  71. Zeyuan Deng, Jing Li, Lin Lei. Bailey's Industrial Oil and Fat Products. 2021.
    https://doi.org/10.1002/047167849X.bio103
  72. Alexander Kalinkovich, Gregory Livshits. Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Research Reviews 2017;35:200
    https://doi.org/10.1016/j.arr.2016.09.008
  73. Mélanie Le Barz, Noëmie Daniel, Thibault V. Varin, Sabrine Naimi, Véronique Demers‐Mathieu, Geneviève Pilon, Julie Audy, Émilie Laurin, Denis Roy, Maria C. Urdaci, Daniel St‐Gelais, Ismail Fliss, André Marette. In vivo screening of multiple bacterial strains identifies Lactobacillus rhamnosus Lb102 and Bifidobacterium animalis ssp. lactis Bf141 as probiotics that improve metabolic disorders in a mouse model of obesity . FASEB j. 2019;33:4921
    https://doi.org/10.1096/fj.201801672R
  74. Nader Shaban, Caroline L Hoad, Iyad Naim, Meshari Alshammari, Shellie Jean Radford, Christopher Clarke, Luca Marciani, Gordon Moran. Imaging in inflammatory bowel disease: current and future perspectives. Frontline Gastroenterol 2022;13:e28
    https://doi.org/10.1136/flgastro-2022-102117
  75. Jumana Saleh, Muna Al‐Maqbali, Dalia Abdel‐Hadi. Comprehensive Physiology. 2022.
    https://doi.org/10.1002/cphy.c170037
  76. Flavia Giolo De Carvalho, Gabriela Batitucci, Gabriela Ferreira Abud, Ellen Cristini de Freitas. Taurine 12. 2022.
    https://doi.org/10.1007/978-3-030-93337-1_27
  77. Dara Bakar, Raman Mehrzad. The Link Between Obesity and Cancer. 2022.
    https://doi.org/10.1016/B978-0-323-90965-5.00006-4
  78. Sera Park, Dae-Young Park, Jaeryung Kim, Kyung In Woo, Yoon-Duck Kim, Jisang Han, Tae-Young Chung, Hoon-Suk Cha, Dong Hui Lim. Enhanced orbital adipogenesis in a mouse model of T-cell-mediated autoimmunity, zymosan A-treated SKG mice: Implications for Graves’ ophthalmopathy. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-64402-9
  79. Mia C. Borlongan, Dipongkor Saha, Hongbin Wang. Tumor Microenvironment: A Niche for Cancer Stem Cell Immunotherapy. Stem Cell Rev and Rep 2023
    https://doi.org/10.1007/s12015-023-10639-6
  80. Darlene E. Berryman, Brooke Henry, Rikke Hjortebjerg, Edward O. List, John J. Kopchick. Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic. Expert Review of Endocrinology & Metabolism 2016;11:197
    https://doi.org/10.1586/17446651.2016.1147950
  81. Qingzhang Zhu, Philipp E. Scherer. Immunologic and endocrine functions of adipose tissue: implications for kidney disease. Nat Rev Nephrol 2018;14:105
    https://doi.org/10.1038/nrneph.2017.157
  82. Wenjuan Zhang, Lei Xu, Tingting Luo, Feng Wu, Bin Zhao, Xianqi Li. The etiology of Bell’s palsy: a review. J Neurol 2020;267:1896
    https://doi.org/10.1007/s00415-019-09282-4
  83. Seung-Cheol Lee, Yoo-Jung Lee, Inho Choi, Min Kim, Jung-Suk Sung. CXCL16/CXCR6 Axis in Adipocytes Differentiated from Human Adipose Derived Mesenchymal Stem Cells Regulates Macrophage Polarization. Cells 2021;10:3410
    https://doi.org/10.3390/cells10123410
  84. Emily J. Vohralik, Annalise M. Psaila, Alexander J. Knights, Kate G. R. Quinlan. EoTHINophils: Eosinophils as key players in adipose tissue homeostasis. Clin Exp Pharma Physio 2020;47:1495
    https://doi.org/10.1111/1440-1681.13304
  85. Federica Zatterale, Michele Longo, Jamal Naderi, Gregory Alexander Raciti, Antonella Desiderio, Claudia Miele, Francesco Beguinot. Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Front. Physiol. 2020;10
    https://doi.org/10.3389/fphys.2019.01607
  86. Yisheng Cai, Xuemei Zuo, Yuyang Zuo, Shuang Wu, Weiwei Pang, Keqiang Ma, Qiaorong Yi, Lijun Tan, Hongwen Deng, Xiaochao Qu, Xiangding Chen. Transcriptomic analysis reveals shared gene signatures and molecular mechanisms between obesity and periodontitis. Front. Immunol. 2023;14
    https://doi.org/10.3389/fimmu.2023.1101854
  87. Dominika Kanikowska, Alina Kanikowska, Rafał Rutkowski, Małgorzata Włochal, Zofia Orzechowska, Aldona Juchacz, Agnieszka Zawada, Marian Grzymisławski, Magdalena Roszak, Maki Sato, Andrzej Bręborowicz, Janusz Witowski. Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*. Pharmaceutical Biology 2019;57:140
    https://doi.org/10.1080/13880209.2019.1569696
  88. Ehab Bakbak, Daniella C. Terenzi, Justin Z. Trac, Hwee Teoh, Adrian Quan, Stephen A. Glazer, Ori D. Rotstein, Mohammed Al-Omran, Subodh Verma, David A. Hess. Lessons from bariatric surgery: Can increased GLP-1 enhance vascular repair during cardiometabolic-based chronic disease?. Rev Endocr Metab Disord 2021;22:1171
    https://doi.org/10.1007/s11154-021-09669-7
  89. Michele Longo, Federica Zatterale, Jamal Naderi, Luca Parrillo, Pietro Formisano, Gregory Alexander Raciti, Francesco Beguinot, Claudia Miele. Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. IJMS 2019;20:2358
    https://doi.org/10.3390/ijms20092358
  90. Yazan Alwarawrah, Kaitlin Kiernan, Nancie J. MacIver. Changes in Nutritional Status Impact Immune Cell Metabolism and Function. Front. Immunol. 2018;9
    https://doi.org/10.3389/fimmu.2018.01055
  91. Rafia Aziz, Afak Yusuf Sherwani, Saeed Al Mahri, Shuja Shafi Malik, Sameer Mohammad. Why Are Obese People Predisposed to Severe Disease in Viral Respiratory Infections?. Obesities 2023;3:46
    https://doi.org/10.3390/obesities3010005
  92. Hernández, Canfora, Jocken, Blaak. The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity. Nutrients 2019;11:1943
    https://doi.org/10.3390/nu11081943
  93. Alecia M. Blaszczak, Somashekar G. Krishna, Phil A. Hart, David Bradley, Willa Hsueh, Luis F. Lara, Hisham Hussan, Alice Hinton, Darwin L. Conwell, Zobeida Cruz-Monserrate. Class III obesity rather than metabolic syndrome impacts clinical outcomes of acute pancreatitis: A propensity score weighted analysis. Pancreatology 2020;20:1287
    https://doi.org/10.1016/j.pan.2020.08.011
  94. Andreina Bruno, Caterina Di Sano, Hans-Uwe Simon, Pascal Chanez, Angelo Maria Patti, Serena Di Vincenzo, Paola Dino, Vittoria D’Esposito, Pietro Formisano, Francesco Beguinot, Elisabetta Pace. Leptin and TGF-β1 Downregulate PREP1 Expression in Human Adipose-Derived Mesenchymal Stem Cells and Mature Adipocytes. Front. Cell Dev. Biol. 2021;9
    https://doi.org/10.3389/fcell.2021.700481
  95. Myeongjoo Son, Seyeon Oh, Junwon Choi, Ji Tae Jang, Chang Hu Choi, Kook Yang Park, Kuk Hui Son, Kyunghee Byun. The Phlorotannin-Rich Fraction ofEcklonia cavaExtract Attenuated the Expressions of the Markers Related with Inflammation and Leptin Resistance in Adipose Tissue. International Journal of Endocrinology 2020;2020:1
    https://doi.org/10.1155/2020/9142134
  96. Luca Piacentini, Mattia Chiesa, Gualtiero Ivanoe Colombo. Gene Regulatory Network Analysis of Perivascular Adipose Tissue of Abdominal Aortic Aneurysm Identifies Master Regulators of Key Pathogenetic Pathways. Biomedicines 2020;8:288
    https://doi.org/10.3390/biomedicines8080288
  97. Noriaki Kawanishi, Hiroyuki Niihara, Tsubasa Mizokami, Koichi Yada, Katsuhiko Suzuki. Exercise training attenuates neutrophil infiltration and elastase expression in adipose tissue of high-fat-diet-induced obese mice. Physiol Rep 2015;3:e12534
    https://doi.org/10.14814/phy2.12534
  98. Vinodkumar B. Pillai, Mahesh P. Gupta. Is nuclear sirtuin SIRT6 a master regulator of immune function?. American Journal of Physiology-Endocrinology and Metabolism 2021;320:E399
    https://doi.org/10.1152/ajpendo.00483.2020
  99. Yoon Jeong Park, Jeu Park, Jin Young Huh, Injae Hwang, Sung Sik Choe, Jae Bum Kim. Regulatory Roles of Invariant Natural Killer T Cells in Adipose Tissue Inflammation: Defenders Against Obesity-Induced Metabolic Complications. Front. Immunol. 2018;9
    https://doi.org/10.3389/fimmu.2018.01311
  100. Lianghui Diao, Songchen Cai, Jinli Ding, Yong Zeng. Endometrial Gene Expression. 2018.
    https://doi.org/10.1007/978-3-030-28584-5_13
  101. Sivan Cohen, Keiko Danzaki, Nancie J. MacIver. Nutritional effects on T‐cell immunometabolism. Eur J Immunol 2017;47:225
    https://doi.org/10.1002/eji.201646423
  102. Antoni Olona, Subhankar Mukhopadhyay, Charlotte Hateley, Fernando O. Martinez, Siamon Gordon, Jacques Behmoaras. Adipoclast: a multinucleated fat-eating macrophage. BMC Biol 2021;19
    https://doi.org/10.1186/s12915-021-01181-3
  103. Martin Schäfer, Yvette Meißner, Jörn Kekow, Sylvia Berger, Sven Remstedt, Bernhard Manger, Joachim Listing, Anja Strangfeld, Angela Zink. Obesity reduces the real-world effectiveness of cytokine-targeted but not cell-targeted disease-modifying agents in rheumatoid arthritis. 2020;59:1916
    https://doi.org/10.1093/rheumatology/kez535
  104. Jacqueline Herold, Joanna Kalucka. Angiogenesis in Adipose Tissue: The Interplay Between Adipose and Endothelial Cells. Front. Physiol. 2021;11
    https://doi.org/10.3389/fphys.2020.624903
  105. Atilla Engin. Obesity and Lipotoxicity. 2021.
    https://doi.org/10.1007/978-3-319-48382-5_15
  106. José L. Reyes, Danielle T. Vannan, Tina Vo, Aliya Gulamhusein, Paul L. Beck, Raylene A. Reimer, Bertus Eksteen. Neutralization of IL-15 abrogates experimental immune-mediated cholangitis in diet-induced obese mice. Sci Rep 2018;8
    https://doi.org/10.1038/s41598-018-21112-7
  107. Sharmila Ahmad, Markus Hodal Drag, Suraya Mohamad Salleh, Zexi Cai, Mette Olaf Nielsen. Transcriptomics analysis of differentially expressed genes in subcutaneous and perirenal adipose tissue of sheep as affected by their pre- and early postnatal malnutrition histories. BMC Genomics 2021;22
    https://doi.org/10.1186/s12864-021-07672-5
  108. Flávia Giolo De Carvalho, Lauren Sparks. Targeting White Adipose Tissue with Exercise or Bariatric Surgery as Therapeutic Strategies in Obesity. Biology 2019;8:16
    https://doi.org/10.3390/biology8010016
  109. Wenjuan Zhang, Lei Xu, Tingting Luo, Bin Zhao, Feng Wu, Xianqi Li. Immune‐related gene expression profiles of hypothermia adipocytes: Implications for Bell's palsy. Oral Diseases 2019;25:1652
    https://doi.org/10.1111/odi.13126
  110. Robert J. van Eijkeren, Olga Krabbe, Marianne Boes, Henk S. Schipper, Eric Kalkhoven. Endogenous lipid antigens for invariant natural killer T cells hold the reins in adipose tissue homeostasis. Immunology 2018;153:179
    https://doi.org/10.1111/imm.12839
  111. Brandao Bruna Brasil, Sakaguchi Masaji, Batista, Thiago Martins, Hu Jiang, Nie Song, Schepmoes Athena A, BonDurant Lucas, Moreau François, Qian Wei-Jun, Kulkarni N. Rohit, Kahn, C. Ronald. Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy. Molecular Metabolism 2022;64:101572
    https://doi.org/10.1016/j.molmet.2022.101572
  112. Connie W. Y. Ha, Suzanne Devkota. The Mesentery and Inflammation. 2022.
    https://doi.org/10.1007/978-3-031-17774-3_6
  113. Lorena Elena Meliț, Cristina Oana Mărginean, Cristian Dan Mărginean, Maria Oana Săsăran. The Peculiar Trialogue between Pediatric Obesity, Systemic Inflammatory Status, and Immunity. Biology 2021;10:512
    https://doi.org/10.3390/biology10060512
  114. Erin D. Lewis, Zhihong Ren, Jason DeFuria, Martin S. Obin, Simin N. Meydani, Dayong Wu. Dietary supplementation with blueberry partially restores T-cell-mediated function in high-fat-diet-induced obese mice. Br J Nutr 2018;119:1393
    https://doi.org/10.1017/S0007114518001034
  115. Lee-Wei Chen, Pei-Hsuan Chen, Chia-Hua Tang, Jui-Hung Yen. Adipose-derived stromal cells reverse insulin resistance through inhibition of M1 expression in a type 2 diabetes mellitus mouse model. Stem Cell Res Ther 2022;13
    https://doi.org/10.1186/s13287-022-03046-0
  116. Farhad Ahmadi-Kani Golzar, Rozita Fathi, Soleiman Mahjoub. High-fat diet leads to adiposity and adipose tissue inflammation: the effect of whey protein supplementation and aerobic exercise training. Appl. Physiol. Nutr. Metab. 2019;44:255
    https://doi.org/10.1139/apnm-2018-0307
  117. Esther Ramírez-Moreno, José Arias-Rico, Reyna Cristina Jiménez-Sánchez, Diego Estrada-Luna, Angélica Saraí Jiménez-Osorio, Quinatzin Yadira Zafra-Rojas, José Alberto Ariza-Ortega, Olga Rocío Flores-Chávez, Lizbeth Morales-Castillejos, Eli Mireya Sandoval-Gallegos. Role of Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation. Foods 2022;11:1232
    https://doi.org/10.3390/foods11091232
  118. Vian Azzu, Michele Vacca, Samuel Virtue, Michael Allison, Antonio Vidal-Puig. Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease. Gastroenterology 2020;158:1899
    https://doi.org/10.1053/j.gastro.2019.12.054
  119. Xiao-Huan Liu, Yupeng Zhang, Liao Chang, Yang Wei, Na Huang, Jin-Ting Zhou, Cheng Cheng, Jianbo Zhang, Jing Xu, Zongfang Li, Xiaoming Li. Apolipoprotein A-IV reduced metabolic inflammation in white adipose tissue by inhibiting IKK and JNK signaling in adipocytes. Molecular and Cellular Endocrinology 2023;559:111813
    https://doi.org/10.1016/j.mce.2022.111813
  120. Andreas Ritter, Nina-Naomi Kreis, Frank Louwen, Juping Yuan. Obesity and COVID-19: Molecular Mechanisms Linking Both Pandemics. IJMS 2020;21:5793
    https://doi.org/10.3390/ijms21165793
  121. Elizabeth E. Ha, Robert C. Bauer. Emerging Roles for Adipose Tissue in Cardiovascular Disease. ATVB 2018;38
    https://doi.org/10.1161/ATVBAHA.118.311421
  122. Andrea De Lorenzo, Vanessa Estato, Hugo C Castro-Faria-Neto, Eduardo Tibirica. Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity. JIR 2021;Volume 14:2267
    https://doi.org/10.2147/JIR.S282710
  123. Prasad Srikakulapu, Coleen A. McNamara. B Lymphocytes and Adipose Tissue Inflammation. ATVB 2020;40:1110
    https://doi.org/10.1161/ATVBAHA.119.312467
  124. Gabriel Pasquarelli-do-Nascimento, Sabrina Azevedo Machado, Juliana Maria Andrade de Carvalho, Kelly Grace Magalhães. Obesity and adipose tissue impact on T-cell response and cancer immune checkpoint blockade therapy. 2022;2
    https://doi.org/10.1093/immadv/ltac015
  125. Zhiyan Wang, Di Wang, Yi Wang. Cigarette Smoking and Adipose Tissue: The Emerging Role in Progression of Atherosclerosis. Mediators of Inflammation 2017;2017:1
    https://doi.org/10.1155/2017/3102737
  126. Clara Ruiz-Fernández, Vera Francisco, Jesus Pino, Antonio Mera, Miguel Angel González-Gay, Rodolfo Gómez, Francisca Lago, Oreste Gualillo. Molecular Relationships among Obesity, Inflammation and Intervertebral Disc Degeneration: Are Adipokines the Common Link?. IJMS 2019;20:2030
    https://doi.org/10.3390/ijms20082030
  127. Yuan Cao, Yali Song, Pu Ning, Liyu Zhang, Shuang Wu, Juan Quan, Qiao Li. Association between tumor necrosis factor alpha and obstructive sleep apnea in adults: a meta-analysis update. BMC Pulm Med 2020;20
    https://doi.org/10.1186/s12890-020-01253-0
  128. Giuseppe Petito, Federica Cioffi, Nunzia Magnacca, Pieter de Lange, Rosalba Senese, Antonia Lanni. Adipose Tissue Remodeling in Obesity: An Overview of the Actions of Thyroid Hormones and Their Derivatives. Pharmaceuticals 2023;16:572
    https://doi.org/10.3390/ph16040572
  129. Sang-Hyeop Lee, Nak-Hyeon Choi, In-Uk Koh, Bong-Jo Kim, Song Lee, Song-Cheol Kim, Sun Shim Choi. Putative positive role of inflammatory genes in fat deposition supported by altered gene expression in purified human adipocytes and preadipocytes from lean and obese adipose tissues. J Transl Med 2020;18
    https://doi.org/10.1186/s12967-020-02611-6
  130. Marianthi Kalafati, Michael Lenz, Gökhan Ertaylan, Ilja C. W. Arts, Chris T. Evelo, Marleen M. J. van Greevenbroek, Ellen E. Blaak, Michiel Adriaens, Martina Kutmon. Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue. Front. Nutr. 2021;8
    https://doi.org/10.3389/fnut.2021.675935
  131. Purnima Gurung, Karine Moussa, Beverley Adams-Huet, Sridevi Devaraj, Ishwarlal Jialal. Increased mast cell abundance in adipose tissue of metabolic syndrome: relevance to the proinflammatory state and increased adipose tissue fibrosis. American Journal of Physiology-Endocrinology and Metabolism 2019;316:E504
    https://doi.org/10.1152/ajpendo.00462.2018
  132. Yi Zhang, Peng Yang, Ran Cui, Manna Zhang, Hong Li, Chunhua Qian, Chunjun Sheng, Shen Qu, Le Bu. Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization. International Journal of Endocrinology 2015;2015:1
    https://doi.org/10.1155/2015/565760
  133. William Lloyd Haylett, William Frank Ferris. Adipocyte–progenitor cell communication that influences adipogenesis. Cell. Mol. Life Sci. 2020;77:115
    https://doi.org/10.1007/s00018-019-03256-5
  134. Jessica H. Hill, Claudia Solt, Michelle T. Foster. Obesity associated disease risk: the role of inherent differences and location of adipose depots. 2018;33
    https://doi.org/10.1515/hmbci-2018-0012
  135. A Catharine Ross. Impact of chronic and acute inflammation on extra- and intracellular iron homeostasis. The American Journal of Clinical Nutrition 2017;106:1581S
    https://doi.org/10.3945/ajcn.117.155838
  136. Tianyi Qiu, Min Li, Miles A. Tanner, Yan Yang, James R. Sowers, Ronald J. Korthuis, Michael A. Hill. Depletion of dendritic cells in perivascular adipose tissue improves arterial relaxation responses in type 2 diabetic mice. Metabolism 2018;85:76
    https://doi.org/10.1016/j.metabol.2018.03.002
  137. Agnieszka I. Mazur-Bialy. Asprosin Enhances Cytokine Production by a Co-Culture of Fully Differentiated Mature Adipocytes and Macrophages Leading to the Exacerbation of the Condition Typical of Obesity-Related Inflammation. IJMS 2023;24:5745
    https://doi.org/10.3390/ijms24065745
  138. Manuel Picon‐Ruiz, Cynthia Morata‐Tarifa, Janeiro J. Valle‐Goffin, Eitan R. Friedman, Joyce M. Slingerland. Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA A Cancer J Clinicians 2017;67:378
    https://doi.org/10.3322/caac.21405
  139. Maria Moysidou, Sevasti Karaliota, Elisavet Kodela, Maria Salagianni, Yassemi Koutmani, Antonia Katsouda, Konstantia Kodella, Panagiotis Tsakanikas, Styliani Ourailidou, Evangelos Andreakos, Nikolaos Kostomitsopoulos, Dimitris Skokos, Antonios Chatzigeorgiou, Kyoung-Jin Chung, Stefan Bornstein, Mark W. Sleeman, Triantafyllos Chavakis, Katia P. Karalis. CD8+ T cells in beige adipogenesis and energy homeostasis. 2018;3
    https://doi.org/10.1172/jci.insight.95456
  140. Xi Liu, Yuyun Jiang, Jixian Ye, Xuefeng Wang. Helminth infection and helminth-derived products: A novel therapeutic option for non-alcoholic fatty liver disease. Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.999412
  141. Celestine N. Wanjalla, Wyatt J. McDonnell, Ramesh Ram, Abha Chopra, Rama Gangula, Shay Leary, Mona Mashayekhi, Joshua D. Simmons, Christian M. Warren, Samuel Bailin, Curtis L. Gabriel, Liang Guo, Briana D. Furch, Morgan C. Lima, Beverly O. Woodward, LaToya Hannah, Mark A. Pilkinton, Daniela T. Fuller, Kenji Kawai, Renu Virmani, Aloke V. Finn, Alyssa H. Hasty, Simon A. Mallal, Spyros A. Kalams, John R. Koethe. Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells. Cell Reports Medicine 2021;2:100205
    https://doi.org/10.1016/j.xcrm.2021.100205
  142. Giulia Maurizi, Lucio Della Guardia, Angela Maurizi, Antonella Poloni. Adipocytes properties and crosstalk with immune system in obesity‐related inflammation. Journal Cellular Physiology 2018;233:88
    https://doi.org/10.1002/jcp.25855
  143. Antonella Poloni, Giulia Maurizi, Marco Ciarlantini, Martina Medici, Domenico Mattiucci, Stefania Mancini, Angela Maurizi, Massimo Falconi, Attilio Olivieri, Pietro Leoni. Interaction between human mature adipocytes and lymphocytes induces T-cell proliferation. Cytotherapy 2015;17:1292
    https://doi.org/10.1016/j.jcyt.2015.06.007
  144. Vera Francisco, Jesús Pino, Victor Campos-Cabaleiro, Clara Ruiz-Fernández, Antonio Mera, Miguel A. Gonzalez-Gay, Rodolfo Gómez, Oreste Gualillo. Obesity, Fat Mass and Immune System: Role for Leptin. Front. Physiol. 2018;9
    https://doi.org/10.3389/fphys.2018.00640
  145. Lili Ma, Wensu Yu, Xiaomin Dai, Mengmeng Yin, Yujiao Wang, Ying Sun, Xiufang Kong, Xiaomeng Cui, Sifan Wu, Zongfei Ji, Lingying Ma, Huiyong Chen, Jiang Lin, Lindi Jiang. Serum leptin, a potential predictor of long‐term angiographic progression in Takayasu’s arteritis. Int J of Rheum Dis 2019;22:2134
    https://doi.org/10.1111/1756-185X.13718
  146. Mohammed Kh. ElMahdy, Manar G. Helal, Tarek M. Ebrahim. Potential anti-inflammatory effect of dapagliflozin in HCHF diet- induced fatty liver degeneration through inhibition of TNF-α, IL-1β, and IL-18 in rat liver. International Immunopharmacology 2020;86:106730
    https://doi.org/10.1016/j.intimp.2020.106730
  147. Yunfei Luo, Hui Lin. Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease. Immunity Inflam & Disease 2021;9:59
    https://doi.org/10.1002/iid3.391
  148. Denis M. Nyaga, Mark H. Vickers, Craig Jefferies, Jo K. Perry, Justin M. O’Sullivan. Type 1 Diabetes Mellitus-Associated Genetic Variants Contribute to Overlapping Immune Regulatory Networks. Front. Genet. 2018;9
    https://doi.org/10.3389/fgene.2018.00535
  149. Yaqin Zhang, Li Shi, Hongliang Mei, Jiexin Zhang, Yunxia Zhu, Xiao Han, Dalong Zhu. Inflamed macrophage microvesicles induce insulin resistance in human adipocytes. Nutr Metab (Lond) 2015;12
    https://doi.org/10.1186/s12986-015-0016-3
  150. Solange S. Pereira, Jacqueline I. Alvarez-Leite. Low-Grade Inflammation, Obesity, and Diabetes. Curr Obes Rep 2014;3:422
    https://doi.org/10.1007/s13679-014-0124-9
  151. Tae Woo Jung, Yoon Hee Chung, Hyoung-Chun Kim, A M Abd El-Aty, Ji Hoon Jeong. LECT2 promotes inflammation and insulin resistance in adipocytes via P38 pathways. 2018;61:37
    https://doi.org/10.1530/JME-17-0267
  152. Sung Sik Choe, Jin Young Huh, In Jae Hwang, Jong In Kim, Jae Bum Kim. Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders. Front. Endocrinol. 2016;7
    https://doi.org/10.3389/fendo.2016.00030
  153. Wasan Naser, Saeed Maymand, Leni R. Rivera, Timothy Connor, Clifford Liongue, Craig M. Smith, Kathryn Aston‐Mourney, Daniel R. McCulloch, Sean L. McGee, Alister C. Ward. Cytokine‐inducible SH2 domain containing protein contributes to regulation of adiposity, food intake, and glucose metabolism. The FASEB Journal 2022;36
    https://doi.org/10.1096/fj.202101882R
  154. Asmaa Elrakaybi, Katharina Laubner, Qian Zhou, Martin J. Hug, Jochen Seufert. Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?. Molecular Metabolism 2022;64:101549
    https://doi.org/10.1016/j.molmet.2022.101549
  155. Pang-Kuo Lo, Yuan Yao, Qun Zhou. Single-Cell RNA-seq Reveals Obesity-Induced Alterations in the Brca1-Mutated Mammary Gland Microenvironment. Cancers 2020;12:2235
    https://doi.org/10.3390/cancers12082235
  156. Ilaria Granata, Enrico Troiano, Mara Sangiovanni, Mario Rosario Guarracino. Integration of transcriptomic data in a genome-scale metabolic model to investigate the link between obesity and breast cancer. BMC Bioinformatics 2019;20
    https://doi.org/10.1186/s12859-019-2685-9
  157. Xiaoqian Hu, Vincenza Cifarelli, Shishuo Sun, Ondrej Kuda, Nada A. Abumrad, Xiong Su. Major role of adipocyte prostaglandin E2 in lipolysis-induced macrophage recruitment. Journal of Lipid Research 2016;57:663
    https://doi.org/10.1194/jlr.M066530
  158. Qiang Chu, Xin Yu, Ruoyi Jia, Yaxuan Wang, Yiru Zhang, Shuang Zhang, Yangyang Liu, Yonglu Li, Wen Chen, Xiang Ye, Xiaodong Zheng. Flavonoids from Apios americana Medikus Leaves Protect RAW264.7 Cells against Inflammation via Inhibition of MAPKs, Akt-mTOR Pathways, and Nfr2 Activation. Oxidative Medicine and Cellular Longevity 2019;2019:1
    https://doi.org/10.1155/2019/1563024
  159. Lina Badimon, Judit Cubedo. Adipose tissue depots and inflammation: effects on plasticity and resident mesenchymal stem cell function. 2017;113:1064
    https://doi.org/10.1093/cvr/cvx096
  160. Zuzanna Majka, Krzysztof Czamara, Joanna Janus, Mariusz Kępczyński, Agnieszka Kaczor. Prominent hypertrophy of perivascular adipocytes due to short-term high fat diet. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2022;1868:166315
    https://doi.org/10.1016/j.bbadis.2021.166315
  161. Emanuel Fabersani, María Claudia Abeijon-Mukdsi, Romina Ross, Roxana Medina, Silvia González, Paola Gauffin-Cano. Specific Strains of Lactic Acid Bacteria Differentially Modulate the Profile of Adipokines In Vitro. Front. Immunol. 2017;8
    https://doi.org/10.3389/fimmu.2017.00266
  162. Soledad López, Sara García-Serrano, Carolina Gutierrez-Repiso, Francisca Rodríguez-Pacheco, Ailec Ho-Plagaro, Concepción Santiago-Fernandez, Gonzalo Alba, Marta Cejudo-Guillen, Alberto Rodríguez-Cañete, Sergio Valdes, Lourdes Garrido-Sanchez, David Pozo, Eduardo García-Fuentes. Tissue-Specific Phenotype and Activation of iNKT Cells in Morbidly Obese Subjects: Interaction with Adipocytes and Effect of Bariatric Surgery. OBES SURG 2018;28:2774
    https://doi.org/10.1007/s11695-018-3215-y
  163. Carmen Paulina Rodríguez, María Cristina González, Carlos A. Aguilar-Salinas, Oralia Nájera-Medina. Peripheral Lymphocytes, Obesity, and Metabolic Syndrome in Young Adults: An Immunometabolism Study. Metabolic Syndrome and Related Disorders 2018;16:342
    https://doi.org/10.1089/met.2018.0005
  164. Victoria Stiglbauer, Stefanie Gamradt, Marie Scherzer, Jelena Brasanac, Christian Otte, Matthias Rose, Tobias Hofmann, Kim Hinkelmann, Stefan M. Gold. Immunological substrates of depressive symptoms in patients with severe obesity: An exploratory study. Cell Biochemistry & Function 2021;39:423
    https://doi.org/10.1002/cbf.3608
  165. Ivonne Palacios-Marin, Dolors Serra, Josep Jimenez-Chillarón, Laura Herrero, Marijana Todorčević. Adipose Tissue Dynamics: Cellular and Lipid Turnover in Health and Disease. Nutrients 2023;15:3968
    https://doi.org/10.3390/nu15183968
  166. Chao Liu, Qian Wang, Bing Sun, Xiangying Meng, Lan Li, Liuchun Yang, Yang Cong, Jiannan Liu, Liang Xuan, Yan Huang, Shikai Wu. Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients. IUBMB Life 2018;70:237
    https://doi.org/10.1002/iub.1721
  167. Aline Rissetti Roquetto, Carolina Soares Moura, Valfredo de Almeida Santos-Junior, Paulo Otávio Sammarco Oliveira, Karla Idelça Aires Machado, Gessika Cristina Borges Castro Carvalho, Eder Müller Risso, Jaime Amaya-Farfan. Moderate intake of BCAA-rich protein improves glucose homeostasis in high-fat-fed mice. The Journal of Nutritional Biochemistry 2020;80:108332
    https://doi.org/10.1016/j.jnutbio.2019.108332
  168. Meenakshi Sudhakaran, Andrea I. Doseff. The Targeted Impact of Flavones on Obesity-Induced Inflammation and the Potential Synergistic Role in Cancer and the Gut Microbiota. Molecules 2020;25:2477
    https://doi.org/10.3390/molecules25112477
  169. Floriana Rotondo, Ana-Cecilia Ho-Palma, María del Mar Romero, Xavier Remesar, José Antonio Fernández-López, Marià Alemany. Higher lactate production from glucose in cultured adipose nucleated stromal cells than for rat adipocytes. Adipocyte 2019;8:61
    https://doi.org/10.1080/21623945.2019.1569448
  170. Oksana Yu. Kytikova, T. A. Gvozdenko, M. V. Antonyuk. The role of system inflammation in bronchial asthma and obesity. Klin. med. 2018;96:784
    https://doi.org/10.18821/0023-2149-2018-96-9-784-790
  171. Durgesh Kumar, Kripa Shankar, Saraswati Patel, Abhishek Gupta, Salil Varshney, Sanchita Gupta, Sujith Rajan, Ankita Srivastava, Achchhe Lal Vishwakarma, Anil N. Gaikwad. Chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: Implications of nitric oxide. Molecular and Cellular Endocrinology 2018;477:15
    https://doi.org/10.1016/j.mce.2018.05.010
  172. Hong-Jin Chen, Ting Meng, Ping-Jin Gao, Cheng-Chao Ruan. The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease. Front. Endocrinol. 2021;12
    https://doi.org/10.3389/fendo.2021.652246
  173. Hun Soo Chang, Tae-Hyeong Lee, Ji Ae Jun, Ae Rin Baek, Jong-Sook Park, So-My Koo, Yang- Ki Kim, Ho Sung Lee, Choon-Sik Park. Neutrophilic inflammation in asthma: mechanisms and therapeutic considerations. Expert Review of Respiratory Medicine 2017;11:29
    https://doi.org/10.1080/17476348.2017.1268919
  174. Yisen Deng, Xuming Wang, Zhan Liu, Xiaoshuo Lv, Bo Ma, Qiangqiang Nie, Xueqiang Fan, Yuguang Yang, Zhidong Ye, Peng Liu, Jianyan Wen, Ken-ichi Aihara. In Silico Identification of Key Genes and Immune Infiltration Characteristics in Epicardial Adipose Tissue from Patients with Coronary Artery Disease. BioMed Research International 2022;2022:1
    https://doi.org/10.1155/2022/5610317
  175. E. N. Proshkina, I. A. Solovev, M. V. Shaposhnikov, A. A. Moskalev. Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions. Mol Biol 2020;54:777
    https://doi.org/10.1134/S0026893320060096
  176. Zheng‐mei Lv, Qi Wang, Yuan‐hua Chen, Sheng‐hua Wang, Dao‐qi Huang. Resveratrol attenuates inflammation and oxidative stress in epididymal white adipose tissue: Implications for its involvement in improving steroidogenesis in diet‐induced obese mice. Molecular Reproduction Devel 2015;82:321
    https://doi.org/10.1002/mrd.22478
  177. K. S. Petersen, C. Smith. Ageing-Associated Oxidative Stress and Inflammation Are Alleviated by Products from Grapes. Oxidative Medicine and Cellular Longevity 2016;2016:1
    https://doi.org/10.1155/2016/6236309
  178. Soumaya Kouidhi, Muhammad Zaeem Noman, Claudine Kieda, Amel Benammar Elgaaied, Salem Chouaib. Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function. Front. Immunol. 2016;7
    https://doi.org/10.3389/fimmu.2016.00114
  179. O. Yu. Kytikova, T. P. Novgorodtseva, M. V. Antonyuk, T. A. Gvozdenko. The role of neurotrophic growth factors in the pathophysiology of bronchial asthma associated with obesity. Bûll. sib. med. 2021;20:158
    https://doi.org/10.20538/1682-0363-2021-1-158-167
  180. Lei Zhang, Yi-Jing Han, Xian Zhang, Xin Wang, Bin Bao, Wei Qu, Jian Liu. Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages. Diabetologia 2016;59:2219
    https://doi.org/10.1007/s00125-016-4039-8
  181. Tiantian Wang, Chengqi He. Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine & Growth Factor Reviews 2018;44:38
    https://doi.org/10.1016/j.cytogfr.2018.10.002
  182. Barbara Tomasello, Giuseppe Antonio Malfa, Alfonsina La Mantia, Natalizia Miceli, Giuseppe Sferrazzo, Maria Fernanda Taviano, Claudia Di Giacomo, Marcella Renis, Rosaria Acquaviva. Anti-adipogenic and anti-oxidant effects of a standardised extract of Moro blood oranges (Citrus sinensis(L.) Osbeck) during adipocyte differentiation of 3T3-L1 preadipocytes. Natural Product Research 2021;35:2660
    https://doi.org/10.1080/14786419.2019.1660337
  183. Fabiano Henrique Rodrigues Soares, Alexandra Braga Furstenberger, Layssa Carolinne de Sousa Carvalho, Melissa Yolanda Soares Melo, Josivan Gomes Lima, Maria Bernardete Cordeiro de Sousa. Can body mass index identify cardiac autonomic dysfunction in women who are apparently healthy?. Women & Health 2020;60:168
    https://doi.org/10.1080/03630242.2019.1613472
  184. Sunhye Shin, Asma S. El-Sabbagh, Brandon E. Lukas, Skylar J. Tanneberger, Yuwei Jiang. Adipose stem cells in obesity: challenges and opportunities. 2020;40
    https://doi.org/10.1042/BSR20194076
  185. ARYANE C.O. PINHO, ANA BURGEIRO, MARIA JOÃO PEREIRA, EUGENIA CARVALHO. Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial adipose tissue. An. Acad. Bras. Ciênc. 2022;94
    https://doi.org/10.1590/0001-3765202220201819
  186. Dong-Mei Zhang, Rui-Qing Jiao, Ling-Dong Kong. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients 2017;9:335
    https://doi.org/10.3390/nu9040335
  187. Ying Sun, Elias Rawish, Henry M. Nording, Harald F. Langer. Inflammation in Metabolic and Cardiovascular Disorders—Role of Oxidative Stress. Life 2021;11:672
    https://doi.org/10.3390/life11070672
  188. Anna-Lena Schäfer, Alexandra Eichhorst, Carolin Hentze, Antoine N. Kraemer, Anaïs Amend, Dalina T. L. Sprenger, Cara Fluhr, Stephanie Finzel, Christoph Daniel, Ulrich Salzer, Marta Rizzi, Reinhard E. Voll, Nina Chevalier. Low Dietary Fiber Intake Links Development of Obesity and Lupus Pathogenesis. Front. Immunol. 2021;12
    https://doi.org/10.3389/fimmu.2021.696810
  189. Mahin Khatami. Inflammation, Aging and Cancer. 2021.
    https://doi.org/10.1007/978-3-319-66475-0_6
  190. Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami, Giuditta Perozzi. Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition. Genes Nutr 2017;12
    https://doi.org/10.1186/s12263-017-0583-1
  191. Radheshyam Maurya, Prince Sebastian, Madhulika Namdeo, Moodu Devender, Arieh Gertler. COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality. Front. Immunol. 2021;12
    https://doi.org/10.3389/fimmu.2021.649359
  192. Angelika Więckowska-Gacek, Anna Mietelska-Porowska, Małgorzata Wydrych, Urszula Wojda. Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration. Ageing Research Reviews 2021;70:101397
    https://doi.org/10.1016/j.arr.2021.101397
  193. Sameer Mohammad, Rafia Aziz, Saeed Al Mahri, Shuja Shafi Malik, Esraa Haji, Altaf Husain Khan, Tanvir Saleem Khatlani, Abderrezak Bouchama. Obesity and COVID-19: what makes obese host so vulnerable?. Immun Ageing 2021;18
    https://doi.org/10.1186/s12979-020-00212-x
  194. Indranil Biswas, Shashank Kumar Maurya, Sabyasachi Senapati. Obesity and Cancer. 2021.
    https://doi.org/10.1007/978-981-16-1846-8_5
  195. Tae Woo Jung, Jinwoo Park, Jaw Long Sun, Sung Ho Ahn, A.M. Abd El-Aty, Ahmet Hacimuftuoglu, Hyoung-Chun Kim, Jae-Han Shim, SungShik Shin, Ji Hoon Jeong. Administration of kynurenic acid reduces hyperlipidemia-induced inflammation and insulin resistance in skeletal muscle and adipocytes. Molecular and Cellular Endocrinology 2020;518:110928
    https://doi.org/10.1016/j.mce.2020.110928
  196. Abhishek Sanyal, Jennifer Naumann, Linda Sarah Hoffmann, Agnieszka Chabowska-Kita, Anna Ehrlund, Andreas Schlitzer, Peter Arner, Matthias Blüher, Alexander Pfeifer. Interplay between Obesity-Induced Inflammation and cGMP Signaling in White Adipose Tissue. Cell Reports 2017;18:225
    https://doi.org/10.1016/j.celrep.2016.12.028
  197. Daniel Elieh Ali Komi, Farzaneh Shafaghat, Mark Christian. Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions. Clinic Rev Allerg Immunol 2020;58:388
    https://doi.org/10.1007/s12016-020-08785-7
  198. Dan Li, Tian Zhang, Jinjian Lu, Cheng Peng, Ligen Lin. Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation. Critical Reviews in Food Science and Nutrition 2021;61:1947
    https://doi.org/10.1080/10408398.2020.1768044
  199. Ichiro Misumi, Joshua Starmer, Toru Uchimura, Melinda A. Beck, Terry Magnuson, Jason K. Whitmire. Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection. Cell Reports 2019;27:514
    https://doi.org/10.1016/j.celrep.2019.03.030
  200. Jin Young Huh, Shannon M. Reilly, Mohammad Abu-Odeh, Anne N. Murphy, Sushil K. Mahata, Jinyu Zhang, Yoori Cho, Jong Bae Seo, Chao-Wei Hung, Courtney R. Green, Christian M. Metallo, Alan R. Saltiel. TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. Cell Metabolism 2020;32:1012
    https://doi.org/10.1016/j.cmet.2020.10.010
  201. Thea Magrone, Emilio Jirillo. Childhood Obesity: Immune Response and Nutritional Approaches. Front. Immunol. 2015;6
    https://doi.org/10.3389/fimmu.2015.00076
  202. N. Molina, A.P. Bolin, R. Otton. Green tea polyphenols change the profile of inflammatory cytokine release from lymphocytes of obese and lean rats and protect against oxidative damage. International Immunopharmacology 2015;28:985
    https://doi.org/10.1016/j.intimp.2015.08.011
  203. Alex E. Mohr, Eric Gumpricht, Dorothy D. Sears, Karen L. Sweazea. Recent advances and health implications of dietary fasting regimens on the gut microbiome. American Journal of Physiology-Gastrointestinal and Liver Physiology 2021;320:G847
    https://doi.org/10.1152/ajpgi.00475.2020
  204. Alireza Shoae-Hassani, Maryam Behfar, Seyed Abdolreza Mortazavi-Tabatabaei, Jafar Ai, Rashin Mohseni, Amir Ali Hamidieh. Natural Killer Cells from the Subcutaneous Adipose Tissue Underexpress the NKp30 and NKp44 in Obese Persons and Are Less Active against Major Histocompatibility Complex Class I Non-Expressing Neoplastic Cells. Front. Immunol. 2017;8
    https://doi.org/10.3389/fimmu.2017.01486
  205. Jennifer M. Monk, Danyelle M. Liddle, Amber L. Hutchinson, Lindsay E. Robinson. Immunometabolism. 2017.
    https://doi.org/10.1007/978-1-0716-0802-9_9
  206. Valentina Ceccarelli, Ilaria Barchetta, Flavia Agata Cimini, Laura Bertoccini, Caterina Chiappetta, Danila Capoccia, Raffaella Carletti, Claudio Di Cristofano, Gianfranco Silecchia, Mario Fontana, Frida Leonetti, Andrea Lenzi, Marco Giorgio Baroni, Eugenio Barone, Maria Gisella Cavallo. Reduced Biliverdin Reductase-A Expression in Visceral Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human Obesity. IJMS 2020;21:9091
    https://doi.org/10.3390/ijms21239091
  207. Francesca Rossi, Giulia Bellini, Livio Luongo, Iolanda Manzo, Salvatore Tolone, Chiara Tortora, Maria Ester Bernardo, Anna Grandone, Antonella Conforti, Ludovico Docimo, Bruno Nobili, Laura Perrone, Franco Locatelli, Sabatino Maione, Emanuele Miraglia del Giudice. Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation. 2016;101:3469
    https://doi.org/10.1210/jc.2015-4381
  208. Jiyoung Yoon, Han-Na Um, Jinsun Jang, Young-An Bae, Woo-Jae Park, Hee Joo Kim, Mee-Sup Yoon, Il Yup Chung, YunJae Jung. Eosinophil Activation by Toll-Like Receptor 4 Ligands Regulates Macrophage Polarization. Front. Cell Dev. Biol. 2019;7
    https://doi.org/10.3389/fcell.2019.00329
  209. Olga Sierawska, Paulina Niedźwiedzka-Rystwej. Adipokines as potential biomarkers for type 2 diabetes mellitus in cats. Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.950049
  210. Kalyana C. Nandipati, Saravanan Subramanian, Devendra K. Agrawal. Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance. Mol Cell Biochem 2017;426:27
    https://doi.org/10.1007/s11010-016-2878-8
  211. Robert J. van Eijkeren, Imogen Morris, Anouska Borgman, Angela Markovska, Eric Kalkhoven. Cytokine Output of Adipocyte-iNKT Cell Interplay Is Skewed by a Lipid-Rich Microenvironment. Front. Endocrinol. 2020;11
    https://doi.org/10.3389/fendo.2020.00479
  212. Luis D'Marco, Valery Morillo, José Luis Gorriz, María K. Suarez, Manuel Nava, Ángel Ortega, Heliana Parra, Nelson Villasmil, Joselyn Rojas-Quintero, Valmore Bermúdez, Markus Wallner. SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence. Journal of Diabetes Research 2021;2021:1
    https://doi.org/10.1155/2021/9032378
  213. Jeu Park, Jee Hyung Sohn, Sang Mun Han, Yoon Jeong Park, Jin Young Huh, Sung Sik Choe, Jae Bum Kim. Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism. Front. Immunol. 2021;11
    https://doi.org/10.3389/fimmu.2020.598566
  214. Dakshnapriya Balasubbramanian, Brett M. Mitchell. Lymphatics in Cardiovascular Physiology. Cold Spring Harb Perspect Med 2022;12:a041173
    https://doi.org/10.1101/cshperspect.a041173
  215. Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim, Taeseung Lee. β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathway. J Biomed Sci 2018;25
    https://doi.org/10.1186/s12929-018-0431-7
  216. Amal A Mohamed, Alshymaa Hassnine, Amr Elsayed, Mahmoud Montaser, Yasmeen Ismail, Ahmed El-Demery, Eman Sultan, Rania S Abdel Aziz, Eman Eldemiry, Radwa Hagag, Amal A El-Kholy, Eman Salah. Isotretinoin Induced Hyperlipidemia and Impact of Leptin Gene rs 7799039 Polymorphism in Safety of Acne Patients. PGPM 2021;Volume 14:1679
    https://doi.org/10.2147/PGPM.S341723
  217. Kristin Thiele, Lianghui Diao, Petra Clara Arck. Immunometabolism, pregnancy, and nutrition. Semin Immunopathol 2018;40:157
    https://doi.org/10.1007/s00281-017-0660-y
  218. Vera Francisco, Jesus Pino, Miguel Angel Gonzalez‐Gay, Antonio Mera, Francisca Lago, Rodolfo Gómez, Ali Mobasheri, Oreste Gualillo. Adipokines and inflammation: is it a question of weight?. British J Pharmacology 2018;175:1569
    https://doi.org/10.1111/bph.14181
  219. Manuela Del Cornò, Lucia Conti, Sandra Gessani. Innate Lymphocytes in Adipose Tissue Homeostasis and Their Alterations in Obesity and Colorectal Cancer. Front. Immunol. 2018;9
    https://doi.org/10.3389/fimmu.2018.02556
  220. Simone Bini, Laura D’Erasmo, Alessia Di Costanzo, Ilenia Minicocci, Valeria Pecce, Marcello Arca. The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?. IJMS 2021;22:742
    https://doi.org/10.3390/ijms22020742
  221. Leszek Szablewski. From obesity through immunity to type 2 diabetes mellitus. Int J Diabetes Dev Ctries 2017;37:407
    https://doi.org/10.1007/s13410-016-0531-4
  222. Samantha Enstad, Sukhinder Cheema, Raymond Thomas, Raina N. Fichorova, Camilia R. Martin, Perrie O’Tierney-Ginn, Carol L. Wagner, Sarbattama Sen. The impact of maternal obesity and breast milk inflammation on developmental programming of infant growth. Eur J Clin Nutr 2021;75:180
    https://doi.org/10.1038/s41430-020-00720-5
  223. Iván Arias de la Rosa, Alejandro Escudero-Contreras, Miriam Ruiz-Ponce, Cristóbal Román-Rodríguez, Carlos Pérez-Sánchez, María del Carmen Ábalos-Aguilera, Rafaela Ortega-Castro, Juan Alcaide, Mora Murri, Pilar Font, Jerusalem Calvo-Gutiérrez, Maria Luque-Tevar, Alejandra Maria Patiño-Trives, Rocío Guzmán-Ruiz, Maria del Mar Malagón, Francisco José Tinahones, Eduardo Collantes-Estévez, Chary López-Pedrera, Nuria Barbarroja. Molecular Changes in the Adipose Tissue Induced by Rheumatoid Arthritis: Effects of Disease-Modifying Anti-Rheumatic Drugs. Front. Immunol. 2021;12
    https://doi.org/10.3389/fimmu.2021.744022
  224. Eyerahi Bravo-Flores, Ismael Mancilla-Herrera, Salvador Espino y Sosa, Marco Ortiz-Ramirez, Verónica Flores-Rueda, Francisco Ibargüengoitia-Ochoa, Carlos Ibañez, Elena Zambrano, Mario Solis-Paredes, Otilia Perichart-Perera, Maribel Sanchez-Martinez, Diana Medina-Bastidas, Enrique Reyes-Muñoz, Guadalupe Estrada-Gutierrez. Macrophage Populations in Visceral Adipose Tissue from Pregnant Women: Potential Role of Obesity in Maternal Inflammation. IJMS 2018;19:1074
    https://doi.org/10.3390/ijms19041074
  225. Winkler, Hempel, Hsu, Gericke, Kühne, Brückner, Erler, Burkhardt, Christ. Immune-Deficient Pfp/Rag2-/- Mice Featured Higher Adipose Tissue Mass and Liver Lipid Accumulation with Growing Age than Wildtype C57BL/6N Mice. Cells 2019;8:775
    https://doi.org/10.3390/cells8080775
  226. Christopher G. Bell. The Epigenomic Analysis of Human Obesity. Obesity 2017;25:1471
    https://doi.org/10.1002/oby.21909
  227. I.V. Wagner, N. Klöting, N. Atanassova, I. Savchuk, C. Spröte, W. Kiess, O. Söder, K. Svechnikov. Prepubertal onset of obesity negatively impacts on testicular steroidogenesis in rats. Molecular and Cellular Endocrinology 2016;437:154
    https://doi.org/10.1016/j.mce.2016.08.027
  228. Yongming Sang, Lauren E. Shields, Eric R. Sang, Haijun Si, Alexis Pigg, Frank Blecha. Ileal transcriptome analysis in obese rats induced by high-fat diets and an adenoviral infection. Int J Obes 2019;43:2134
    https://doi.org/10.1038/s41366-019-0323-2
  229. Natalie Theobalt, Isabel Hofmann, Sonja Fiedler, Simone Renner, Georg Dhom, Annette Feuchtinger, Axel Walch, Martin Hrabĕ de Angelis, Eckhard Wolf, Rüdiger Wanke, Andreas Blutke, Konradin Metze. Unbiased analysis of obesity related, fat depot specific changes of adipocyte volumes and numbers using light sheet fluorescence microscopy. PLoS ONE 2021;16:e0248594
    https://doi.org/10.1371/journal.pone.0248594
  230. Sudharsana R. Ande, K. Hoa Nguyen, B. L. Grégoire Nyomba, Suresh Mishra. Prohibitin-induced, obesity-associated insulin resistance and accompanying low-grade inflammation causes NASH and HCC. Sci Rep 2016;6
    https://doi.org/10.1038/srep23608
  231. Dawei Zhang, Wenjing Wu, Xin Huang, Ke Xu, Cheng Zheng, Jin Zhang. Comparative analysis of gene expression profiles in differentiated subcutaneous adipocytes between Jiaxing Black and Large White pigs. BMC Genomics 2021;22
    https://doi.org/10.1186/s12864-020-07361-9
  232. Masuko Kobori, Yumiko Takahashi, Mutsumi Sakurai, Yukari Akimoto, Tojiro Tsushida, Hideaki Oike, Katsunari Ippoushi. Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet‐induced obese mice. Molecular Nutrition Food Res 2016;60:300
    https://doi.org/10.1002/mnfr.201500595
  233. Alex S. Yamashita, Thiago Belchior, Fábio S. Lira, Nicolette C. Bishop, Barbara Wessner, José C. Rosa, William T. Festuccia. Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors. Mediators of Inflammation 2018;2018:1
    https://doi.org/10.1155/2018/8261432
  234. Yoon Jeong Park, Sung Sik Choe, Jee Hyung Sohn, Jae Bum Kim. The role of glucose-6-phosphate dehydrogenase in adipose tissue inflammation in obesity. Adipocyte 2017;6:147
    https://doi.org/10.1080/21623945.2017.1288321
  235. Zejun Liang, Tianxiao Zhang, Honghong Liu, Zhenlin Li, Lihong Peng, Changyi Wang, Tiantian Wang. Inflammaging: The ground for sarcopenia?. Experimental Gerontology 2022;168:111931
    https://doi.org/10.1016/j.exger.2022.111931
  236. Michelle Summerfield, Yi Zhou, Tianhao Zhou, Chaodong Wu, Gianfranco Alpini, Ke K. Zhang, Linglin Xie, Shrikant Anant. A long-term maternal diet transition from high-fat diet to normal fat diet during pre-pregnancy avoids adipose tissue inflammation in next generation. PLoS ONE 2018;13:e0209053
    https://doi.org/10.1371/journal.pone.0209053
  237. Geir Bjørklund, Salvatore Chirumbolo. Role of oxidative stress and antioxidants in daily nutrition and human health. Nutrition 2017;33:311
    https://doi.org/10.1016/j.nut.2016.07.018
  238. Jae Sik Yu, Namood E. Sahar, Yan-Ran Bi, Kiwon Jung, Changhyun Pang, Joo Young Huh, Ki Hyun Kim. The Effects of Triterpenoid Saponins from the Seeds of Momordica cochinchinensis on Adipocyte Differentiation and Mature Adipocyte Inflammation. Plants 2020;9:984
    https://doi.org/10.3390/plants9080984
  239. Valerie A. Gerriets, Nancie J. MacIver. Role of T Cells in Malnutrition and Obesity. Front. Immunol. 2014;5
    https://doi.org/10.3389/fimmu.2014.00379
  240. Calvin C. Chan, Michelle S.M.A. Damen, Pablo C. Alarcon, Joan Sanchez-Gurmaches, Senad Divanovic. Inflammation and Immunity: From an Adipocyte's Perspective. Journal of Interferon & Cytokine Research 2019;39:459
    https://doi.org/10.1089/jir.2019.0014
  241. Rens L.J. van Meijel, Ellen E. Blaak, Gijs H. Goossens. Mechanisms and Manifestations of Obesity in Lung Disease. 2019.
    https://doi.org/10.1016/B978-0-12-813553-2.00001-4
  242. Divya Sharma, Sanjay Arora, Amrita Banerjee, Jagdish Singh. Improved insulin sensitivity in obese-diabetic mice via chitosan Nanomicelles mediated silencing of pro-inflammatory Adipocytokines. Nanomedicine: Nanotechnology, Biology and Medicine 2021;33:102357
    https://doi.org/10.1016/j.nano.2020.102357
  243. Jeu Park, Jin Young Huh, Jiyoung Oh, Jong In Kim, Sang Mun Han, Kyung Cheul Shin, Yong Geun Jeon, Sung Sik Choe, Jiyoung Park, Jae Bum Kim. Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity. Genes Dev. 2019;33:1657
    https://doi.org/10.1101/gad.329557.119
  244. . TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways. 2015;38:1037
    https://doi.org/10.14348/molcells.2015.0100
  245. Jin Young Huh, Alan R. Saltiel. Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease. Exp Mol Med 2021;53:1697
    https://doi.org/10.1038/s12276-021-00712-w
  246. Filiz Yarsilikal Guleroglu, Esra Selvi, Isil Turan Bakirci, Olgu Bafalı, Hatice Argun Atalmis, Merve Yasti Dayan, Aliye Balkan Ozmen, Nazan Yurtcu, Busra Seker Atas, Esma Ozdemir Anayurt, Ali Cetin. Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension. Z Geburtshilfe Neonatol 2023;227:42
    https://doi.org/10.1055/a-1937-1155
  247. M.J. Gunter, S. Alhomoud, M. Arnold, H. Brenner, J. Burn, G. Casey, A.T. Chan, A.J. Cross, E. Giovannucci, R. Hoover, R. Houlston, M. Jenkins, P. Laurent-Puig, U. Peters, D. Ransohoff, E. Riboli, R. Sinha, Z.K. Stadler, P. Brennan, S.J. Chanock. Meeting report from the joint IARC–NCI international cancer seminar series: a focus on colorectal cancer. Annals of Oncology 2019;30:510
    https://doi.org/10.1093/annonc/mdz044
  248. Bastien Vergoni, Pierre-Jean Cornejo, Jérôme Gilleron, Mansour Djedaini, Franck Ceppo, Arnaud Jacquel, Gwennaelle Bouget, Clémence Ginet, Teresa Gonzalez, Julie Maillet, Véronique Dhennin, Marie Verbanck, Patrick Auberger, Philippe Froguel, Jean-François Tanti, Mireille Cormont. DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes. 2016;65:3062
    https://doi.org/10.2337/db16-0014
  249. Agnieszka Irena Mazur-Bialy, Ewa Pocheć, Marcin Zarawski. Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation. IJMS 2017;18:701
    https://doi.org/10.3390/ijms18040701
  250. Jihye Kim, Hana Na, Jung-Ae Kim, Jae-Hwan Nam. What we know and what we need to know about adenovirus 36-induced obesity. Int J Obes 2020;44:1197
    https://doi.org/10.1038/s41366-020-0536-4
  251. Diana L Alba, Jeffrey A Farooq, Matthew Y C Lin, Anne L Schafer, John Shepherd, Suneil K Koliwad. Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans. 2018;103:3194
    https://doi.org/10.1210/jc.2017-02301
  252. Amany Magdy Beshbishy, Helal F. Hetta, Diaa E. Hussein, Abdullah A. Saati, Christian C. Uba, Nallely Rivero-Perez, Adrian Zaragoza-Bastida, Muhammad Ajmal Shah, Tapan Behl, Gaber El-Saber Batiha. Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients. Biology 2020;9:280
    https://doi.org/10.3390/biology9090280
  253. Salvatore Nesci, Anna Spagnoletta, Francesca Oppedisano. Inflammation, Mitochondria and Natural Compounds Together in the Circle of Trust. IJMS 2023;24:6106
    https://doi.org/10.3390/ijms24076106
  254. Ayse Basak Engin. Obesity and Lipotoxicity. 2023.
    https://doi.org/10.1007/978-3-319-48382-5_14
  255. Sandip Mukherjee, Snehasis Das, Dipanjan Chattopadhyay, Shuvasree Sarkar, Subhendu Kumar Chatterjee, Dhrubajyoti Talukdar, Sutapa Mukherjee, Subeer S. Majumdar, Satinath Mukhopadhyay, Mihir K. Chaudhuri, Samir Bhattacharya. Attenuation of macrophage accumulation and polarisation in obese diabetic mice by a small molecule significantly improved insulin sensitivity. Biochemical and Biophysical Research Communications 2018;501:771
    https://doi.org/10.1016/j.bbrc.2018.05.068
  256. S. M. Matt, P. J. Gaskill. Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease. J Neuroimmune Pharmacol 2020;15:114
    https://doi.org/10.1007/s11481-019-09851-4