• Research Article  31 May 2020

    The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability

    Nuclear receptor subfamily group H member 4 (NR1H4), also known as farnesoid X receptor, has been implicated in several cellular processes in the liver and intestine. Preclinical and clinical studies have suggested a role of NR1H4 in colon cancer development; however, how NR1H4 regulates colon cancer cell growth and survival remains unclear. We generated NR1H4 knockout (KO) colon cancer cells using clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein-9 nuc ...

  • Research Article  31 May 2020

    Gametophytic Abortion in Heterozygotes but Not in Homozygotes: Implied Chromosome Rearrangement during T-DNA Insertion at the ASF1 Locus in Arabidopsis

    T-DNA insertional mutations in Arabidopsis genes have conferred huge benefits to the research community, greatly facilitating gene function analyses. However, the insertion process can cause chromosomal rearrangements. Here, we show an example of a likely rearrangement following T-DNA insertion in the Anti-Silencing Function 1B (ASF1B) gene locus on Arabidopsis chromosome 5, so that the phenotype was not relevant to the gene of interest, ASF1B. ASF1 is a histon ...

  • Minireview  31 May 2020

    Cellular Contributors to Hypothalamic Inflammation in Obesity

    The hypothalamus is a crucial organ for the maintenance of appropriate body fat storage. Neurons in the hypothalamic arcuate nucleus (ARH) detect energy shortage or surplus via the circulating concentrations of metabolic hormones and nutrients, and then coordinate energy intake and expenditure to maintain energy homeostasis. Malfunction or loss of hypothalamic ARH neurons results in obesity. Accumulated evidence suggests that hypothalamic inflammation is a key pathological mechanism that links c ...

  • Minireview  31 May 2020

    Ceramide and Sphingosine 1-Phosphate in Liver Diseases

    The liver is an important organ in the regulation of glucose and lipid metabolism. It is responsible for systemic energy homeostasis. When energy need exceeds the storage capacity in the liver, fatty acids are shunted into nonoxidative sphingolipid biosynthesis, which increases the level of cellular ceramides. Accumulation of ceramides alters substrate utilization from glucose to lipids, activates triglyceride storage, and results in the development of both insulin resistance and hepatosteatosis ...

Mol. Cells 2020; 43(6): 501~590
SNAREs in Plant Biotic and Abiotic Stress Responses
Chian Kwon , Jae-Hoon Lee , and Hye Sup Yun
Mol. Cells 2020; 43(6): 501-508  https://doi.org/10.14348/molcells.2020.0007 PDF PubMed Google Scholar Search
Color Sensing and Signal Transmission Diversity of Cyanobacterial Phytochromes and Cyanobacteriochromes
Yvette Villafani , Hee Wook Yang , and Youn-Il Park
Mol. Cells 2020; 43(6): 509-516  https://doi.org/10.14348/molcells.2020.0077 PDF PubMed Google Scholar Search
Research Articles
NSM00158 Specifically Disrupts the CtBP2-p300 Interaction to Reverse CtBP2-Mediated Transrepression and Prevent the Occurrence of Nonunion
Xun Chen , Wentao Zhang , Qian Zhang , Tao Song , Zirui Yu , Zhong Li , Ning Duan , and Xiaoqian Dang
Mol. Cells 2020; 43(6): 517-529  https://doi.org/10.14348/molcells.2020.0042 PDF PubMed Supplementary File(s) Google Scholar Search
Cucurbitacin B Activates Bitter-Sensing Gustatory Receptor Neurons via Gustatory Receptor 33a in Drosophila melanogaster
Suman Rimal , Jiun Sang , Subash Dhakal , and Youngseok Lee
Mol. Cells 2020; 43(6): 530-538  https://doi.org/10.14348/molcells.2020.0019 PDF PubMed Google Scholar Search
CXCR4-STAT3 Axis Plays a Role in Tumor Cell Infiltration in an Orthotopic Mouse Glioblastoma Model
Ji-hun Han , Jeong Seon Yoon , Da-Young Chang , Kyung Gi Cho , Jaejoon Lim , Sung-Soo Kim , and Haeyoung Suh-Kim
Mol. Cells 2020; 43(6): 539-550  https://doi.org/10.14348/molcells.2020.0098 PDF PubMed Google Scholar Search
Genome-Wide Analysis Identifies NURR1-Controlled Network of New Synapse Formation and Cell Cycle Arrest in Human Neural Stem Cells
Soo Min Kim , Soo Young Cho , Min Woong Kim , Seung Ryul Roh , Hee Sun Shin , Young Ho Suh , Dongho Geum , and Myung Ae Lee
Mol. Cells 2020; 43(6): 551-571  https://doi.org/10.14348/molcells.2020.0071 PDF PubMed Supplementary File(s) Google Scholar Search
A Single Natural Variation Determines Cytosolic Ca2+-Mediated Hyperthermosensitivity of TRPA1s from Rattlesnakes and Boas
Eun Jo Du and KyeongJin Kang
Mol. Cells 2020; 43(6): 572-580  https://doi.org/10.14348/molcells.2020.0036 PDF PubMed Supplementary File(s) Google Scholar Search
NELL2 Function in Axon Development of Hippocampal Neurons
Han Rae Kim , Dong Hee Kim , Ji Young An , Dasol Kang , Jeong Woo Park , Eun Mi Hwang , Eun Jin Seo , Il Ho Jang , Chang Man Ha , and Byung Ju Lee
Mol. Cells 2020; 43(6): 581-589  https://doi.org/10.14348/molcells.2020.0032 PDF PubMed Google Scholar Search
Corrigendum to: Resveratrol Exerts Dosage-Dependent Effects on the Self-Renewal and Neural Differentiation of hUC-MSCs
Xinxin Wang, Shanshan Ma, Nan Meng, Ning Yao, Kun Zhang, Qinghua Li, Yanting Zhang, Qu Xing, Kang Han, Jishi Song, Bo Yang, and Fangxia Guan
Mol. Cells 2020; 43(6): 590-590  https://doi.org/10.14348/molcells.2020.1345 PDF PubMed Google Scholar Search
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Current Issue

30 June 2020
Volume 43,
Number 6,
pp. 501~590
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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