• Minireview  31 March 2018

    New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O

    Intracellular communication via ubiquitin (Ub) signaling impacts all aspects of cell biology and regulates pathways critical to human development and viability; therefore aberrations or defects in Ub signaling can contribute to the pathogenesis of human diseases. Ubiquitination consists of the addition of Ub to a substrate protein via coordinated action of E1-activating, E2-conjugating and E3-ligating enzymes. Approximately 40 E2s have been identified in humans, and most are thought to be inv ...

  • Article  31 March 2018

    Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine

    Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonst ...

  • Minireview  31 March 2018

    Evolution and Design Principles of the Diverse Chloroplast Transit Peptides

    Chloroplasts are present in organisms belonging to the kingdom Plantae. These organelles are thought to have originated from photosynthetic cyanobacteria through endosymbiosis. During endosymbiosis, most cyanobacterial genes were transferred to the host nucleus. Therefore, most chloroplast proteins became encoded in the nuclear genome and must return to the chloroplast after translation. The N-terminal cleavable transit peptide (TP) is necessary and sufficient for the import of nucleus-encode ...

  • Article  31 March 2018

    Increased Primary Cilia in Idiopathic Pulmonary Fibrosis

    Primary cilia are solitary, non-motile, axonemal microtubule-based antenna-like organelles that project from the plasma membrane of most mammalian cells and are implicated in transducing hedgehog signals during development. It was recently proposed that aberrant SHH signaling may be implicated in the progression of idiopathic pulmonary fibrosis (IPF). However, the distribution and role of primary cilia in IPF remains unclear. Here, we clearly observed the primary cilia in alveolar epithelial ...


Mol. Cells 2018; 41(3): 161~255
Minireviews
Evolution and Design Principles of the Diverse Chloroplast Transit Peptides
Dong Wook Lee, and Inhwan Hwang
Mol. Cells 2018; 41(3): 161-167  https://doi.org/10.14348/molcells.2018.0033 PDF PubMed PubMed Central PubReader Google Scholar Search
New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O
Daniel Hormaechea-Agulla, Youngjo Kim, Min Sup Song, and Su Jung Song
Mol. Cells 2018; 41(3): 168-178  https://doi.org/10.14348/molcells.2018.0008 PDF PubMed PubMed Central PubReader Google Scholar Search
Articles
Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine
Jingyun Lee, Kimberly Q. McKinney, Antonis J. Pavlopoulos, Meng Niu, Jung Won Kang, Jae Won Oh, Kwang Pyo Kim, and Sunil Hwang
Mol. Cells 2018; 41(3): 179-187  https://doi.org/10.14348/molcells.2018.2110 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Benzidine Induces Epithelial–Mesenchymal Transition of Human Bladder Cancer Cells through Activation of ERK5 Pathway
Xin Sun, Tao Zhang, Qifei Deng, Qirui Zhou, Xianchao Sun, Enlai Li, Dexin Yu, and Caiyun Zhong
Mol. Cells 2018; 41(3): 188-197  https://doi.org/10.14348/molcells.2018.2113 PDF PubMed PubMed Central PubReader Google Scholar Search
Post-Transcriptional Control of Tropoelastin in Aortic Smooth Muscle Cells Affects Aortic Dissection Onset
You-Fei Qi, Chang Shu, Zhan-Xiang Xiao, Ming-Yao Luo, Kun Fang, Yuan-Yuan Guo, Wen-Bo Zhang, and Jie Yue
Mol. Cells 2018; 41(3): 198-206  https://doi.org/10.14348/molcells.2018.2193 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan
Janet Lee, Hyun-Soo Kim, Su-Min Kim, Dong-Ik Kim, and Chang-Woo Lee
Mol. Cells 2018; 41(3): 207-213  https://doi.org/10.14348/molcells.2018.2231 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses
Ji-Seon Kang, Yune-Sahng Hwang, Lark Kyun Kim, Sujung Lee, Wook-Bin Lee, Jeongsil Kim-Ha, and Young-Joon Kim
Mol. Cells 2018; 41(3): 214-223  https://doi.org/10.14348/molcells.2018.2293 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Increased Primary Cilia in Idiopathic Pulmonary Fibrosis
Junguee Lee, Dong Hyun Oh, Ki Cheol Park, Ji Eun Choi, Jong Beom Kwon, Jongho Lee, Kuhn Park, and Hae Joung Sul
Mol. Cells 2018; 41(3): 224-233  https://doi.org/10.14348/molcells.2018.2307 PDF PubMed PubMed Central PubReader Google Scholar Search
Liraglutide Inhibits the Apoptosis of MC3T3-E1 Cells Induced by Serum Deprivation through cAMP/PKA/β-Catenin and PI3K/AKT/GSK3β Signaling Pathways
Xuelun Wu, Shilun Li, Peng Xue, and Yukun Li
Mol. Cells 2018; 41(3): 234-243  https://doi.org/10.14348/molcells.2018.2340 PDF PubMed PubMed Central PubReader Google Scholar Search
Astragaloside IV Prevents Obesity-Associated Hypertension by Improving Pro-Inflammatory Reaction and Leptin Resistance
Ping Jiang, Dufang Ma, Xue Wang, Yongcheng Wang, Yuxin Bi, Jinlong Yang, Xuebing Wang, and Xiao Li
Mol. Cells 2018; 41(3): 244-255  https://doi.org/10.14348/molcells.2018.2156 PDF PubMed PubMed Central PubReader Google Scholar Search
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Current Issue

31 March 2018
Volume 41,
Number 3,
pp. 161~255
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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