Minireview 31 March 2018
Intracellular communication via ubiquitin (Ub) signaling impacts all aspects of cell biology and regulates pathways critical to human development and viability; therefore aberrations or defects in Ub signaling can contribute to the pathogenesis of human diseases. Ubiquitination consists of the addition of Ub to a substrate protein via coordinated action of E1-activating, E2-conjugating and E3-ligating enzymes. Approximately 40 E2s have been identified in humans, and most are thought to be inv ...
Article 31 March 2018
Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonst ...
Minireview 31 March 2018
Chloroplasts are present in organisms belonging to the kingdom Plantae. These organelles are thought to have originated from photosynthetic cyanobacteria through endosymbiosis. During endosymbiosis, most cyanobacterial genes were transferred to the host nucleus. Therefore, most chloroplast proteins became encoded in the nuclear genome and must return to the chloroplast after translation. The N-terminal cleavable transit peptide (TP) is necessary and sufficient for the import of nucleus-encode ...
Article 31 March 2018
Primary cilia are solitary, non-motile, axonemal microtubule-based antenna-like organelles that project from the plasma membrane of most mammalian cells and are implicated in transducing hedgehog signals during development. It was recently proposed that aberrant SHH signaling may be implicated in the progression of idiopathic pulmonary fibrosis (IPF). However, the distribution and role of primary cilia in IPF remains unclear. Here, we clearly observed the primary cilia in alveolar epithelial ...
Mol. Cells 2018; 41(3): 161~255
 |
Current Issue31 March 2018Volume 41, Number 3, pp. 161~255 |
This journal is indexed in Science Citation Index, Scopus, Current Contents®/Life Science, Sci-search®, Research Alert®, Index Medicus, Chemical Abstract Service, and PubMed.
To submit a manuscript, please visit the Molecules and Cells e-submission management system at http://www.ksmcb.or.kr/submission/Login.html, read the Instructions to Authors, and log into the Molecules and Cells e-submission system. For assistance with manuscript submission, please contact: admin@molcells.org.
