Molecules and Cells

Research Article 30 June 2019

Heterogeneous Sequences of Brain Cytoplasmic 200 RNA Formed by Multiple Adenine Nucleotide Insertions

Brain cytoplasmic 200 RNA (BC200 RNA), originally identified as a neuron-specific non-coding RNA, is also observed in various cancer cells that originate from non-neural cells. Studies have revealed diverse functions of BC200 RNA in cancer cells. Accordingly, we hypothesized that BC200 RNA might be modified in cancer cells to generate cancerous BC200 RNA responsible for its cancer-specific functions. Here, we report that BC200 RNA sequences are highly heterogeneous in cancer cells by virtue o ...
Research Article 30 June 2019

Crystal Structure of a Highly Thermostable α-Carbonic Anhydrase from Persephonella marina EX-H1

Bacterial α-type carbonic anhydrase (α-CA) is a zinc metalloenzyme that catalyzes the reversible and extremely rapid interconversion of carbon dioxide to bicarbonate. In this study, we report the first crystal structure of a hyperthermostable α-CA from Persephonella marina EX-H1 (pmCA) in the absence and presence of competitive inhibitor, acetazolamide. The structure reveals a compactly folded pmCA homodimer in which each monomer consists ...
Research Article 30 June 2019

Combination Therapy with a PI3K/mTOR Dual Inhibitor and Chloroquine Enhances Synergistic Apoptotic Cell Death in Epstein–Barr Virus-Infected Gastric Cancer Cells

The phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway is a promising target for gastric cancer (GC) treatment; however the efficacy of PI3K/mTOR dual inhibitors in GC has not yet been maximized. Additionally, the effect of autophagy regulation by PI3K/mTOR dual inhibitors has not been clearly elucidated in GC treatment. We aimed to show that our newly developed PI3K/mTOR dual inhibitor, CMG002, when combined with an autophagy inhibitor, ...
Minireview 30 June 2019

Neurodevelopmental Aspects of RASopathies

RAS gene mutations are frequently found in one third of human cancers. Affecting approximately 1 in 1,000 newborns, germline and somatic gain-of-function mutations in the components of RAS/mitogen-activated protein kinase (RAS/MAPK) pathway has been shown to cause developmental disorders, known as RASopathies. Since RAS-MAPK pathway plays essential roles in proliferation, differentiation and migration involving developmental processes, individuals with RASopathies show abnorm ...

Mol. Cells 2019; 42(6): 441~501

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Neurodevelopmental Aspects of RASopathies

Ye Eun Kim and Seung Tae Baek

Mol. Cells 2019; 42(6): 441-447 https://doi.org/10.14348/molcells.2019.0037

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Research Articles

Combination Therapy with a PI3K/mTOR Dual Inhibitor and Chloroquine Enhances Synergistic Apoptotic Cell Death in Epstein–Barr Virus-Infected Gastric Cancer Cells

Mi-Young Kim, Annie J. Kruger, Ju-Yeon Jeong, Jaehee Kim, Phil kyung Shin, Sun Young Kim, Joo Young Cho, Ki Baik Hahm, and Sung Pyo Hong

Mol. Cells 2019; 42(6): 448-459 https://doi.org/10.14348/molcells.2019.2395

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Crystal Structure of a Highly Thermostable α-Carbonic Anhydrase from Persephonella marina EX-H1

Subin Kim, Jongmin Sung, Jungyoon Yeon, Seung Hun Choi, and Mi Sun Jin

Mol. Cells 2019; 42(6): 460-469 https://doi.org/10.14348/molcells.2019.0029

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The Mechanism of Action of Ghrelin and Motilin in the Pacemaker Potentials of Interstitial Cells of Cajal from the Murine Small Intestine

Jeong Nam Kim and Byung Joo Kim

Mol. Cells 2019; 42(6): 470-479 https://doi.org/10.14348/molcells.2019.0028

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Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates

Sangwoo Ham, Hyojung Kim, Seojin Hwang, Hyunook Kang, Seung Pil Yun, Sangjune Kim, Donghoon Kim, Hyun Sook Kwon, Yun-Song Lee, MyoungLae Cho, Heung-Mook Shin, Heejung Choi, Ka Young Chung, Han Seok Ko, Gum Hwa Lee, and Yunjong Lee

Mol. Cells 2019; 42(6): 480-494 https://doi.org/10.14348/molcells.2019.0091

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Supplementary File(s)

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Heterogeneous Sequences of Brain Cytoplasmic 200 RNA Formed by Multiple Adenine Nucleotide Insertions

Heegwon Shin, Jungmin Lee, Youngmi Kim, Seonghui Jang, Meehyein Kim, and Younghoon Lee

Mol. Cells 2019; 42(6): 495-500 https://doi.org/10.14348/molcells.2019.0108

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Erratum

Erratum to: Roles of Endoplasmic Reticulum Stress in Immune Responses

Jae-Seon So

Mol. Cells 2019; 42(6): 501-501 https://doi.org/10.14348/molcells.2019.1241

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Current Issue

30 June 2019
Volume 42,
Number 6,
pp. 441~501

dRAGging Amino Acid-mTORC1 Signaling by SH3BP4

Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.

Olfactory Carbon Dioxide Detection by Insects and Other Animals

Walton Jones
Received January 30, 2013; Accepted February 2, 2013.

Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B

Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.

A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans

Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*

Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification

Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*

Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci

Hae-Ryong Song, and Yoo-Sun Noh*

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