• Research Article  31 December 2019

    Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p

    MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and is highly encased in exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able to function as carriers to deliver microRNAs into cells. Autoimmune hepatitis is one of the challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether MSC-exosomes can transfer miR-2 ...

  • Research Article  31 December 2019

    Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells

    Mitochondria are highly dynamic organelles that constantly undergo fission and fusion processes that closely related to their function. Disruption of mitochondrial dynamics has been demonstrated in acute kidney injury (AKI), which could eventually result in cell injury and death. Previously, we reported that augmenter of liver regeneration (ALR) alleviates renal tubular epithelial cell injury. Here, we gained further insights into whether the renoprotective roles of ALR are associated with mi ...

  • Research Article  31 December 2019

    Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells

    Piperlongumine (PL), a natural alkaloid compound isolated from long pepper (Piper longum), can selectively kill cancer cells, but not normal cells, by accumulation of reactive oxygen species (ROS). The objective of this study was to investigate functional roles of expression of SETDB1 and FosB during PL treatment in MCF7 breast cancer cells. PL downregulates SETDB1 expression, and decreased SETDB1 expression enhanced caspase 9 dependent-PARP cleavage during PL-induced cell de ...

  • Research Article  31 December 2019

    Involvement of RUNX and BRD Family Members in Restriction Point

    A tumor is an abnormal mass of tissue that arises when cells divide more than they should or do not die when they should. The cellular decision regarding whether to undergo division or death is made at the restriction (R)-point. Consistent with this, an increasingly large body of evidence indicates that deregulation of the R-point decision-making machinery accompanies the formation of most tumors. Although the R-point decision is literally a matter of life and death for the cell, and thus cri ...


Mol. Cells 2019; 42(12): 821~918
Minireviews
Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases
Chanhee Kang
Mol. Cells 2019; 42(12): 821-827  https://doi.org/10.14348/molcells.2019.0298 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
PIWI Proteins and piRNAs in the Nervous System
Kyung Won Kim
Mol. Cells 2019; 42(12): 828-835  https://doi.org/10.14348/molcells.2019.0241 PDF PubMed PubMed Central PubReader Google Scholar Search
Research Articles
Involvement of RUNX and BRD Family Members in Restriction Point
Jung-Won Lee, Tae-Geun Park, and Suk-Chul Bae
Mol. Cells 2019; 42(12): 836-839  https://doi.org/10.14348/molcells.2019.0256 PDF PubMed PubMed Central PubReader Google Scholar Search
c-Cbl Acts as an E3 Ligase Against DDA3 for Spindle Dynamics and Centriole Duplication during Mitosis
Dasom Gwon, Jihee Hong, and Chang-Young Jang
Mol. Cells 2019; 42(12): 840-849  https://doi.org/10.14348/molcells.2019.0142 PDF PubMed PubMed Central PubReader Google Scholar Search
Crystal Structure of the Regulatory Domain of MexT, a Transcriptional Activator of the MexEFOprN Efflux Pump in Pseudomonas aeruginosa
Suhyeon Kim, Songhee H. Kim, Jinsook Ahn, Inseong Jo, Zee-Won Lee, Sang Ho Choi, and NamChul Ha
Mol. Cells 2019; 42(12): 850-857  https://doi.org/10.14348/molcells.2019.0168 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Chromatin Interacting Factor OsVIL2 Is Required for Outgrowth of Axillary Buds in Rice
Jinmi Yoon, Lae-Hyeon Cho, Sichul Lee, Richa Pasriga, Win Tun, Jungil Yang, Hyeryung Yoon, Hee Joong Jeong, Jong-Seong Jeon, and Gynheung An
Mol. Cells 2019; 42(12): 858-868  https://doi.org/10.14348/molcells.2019.0141 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice
Van Anh Do Thi, Hyung Min Jeon, Sang Min Park, Hayyoung Lee, and Young Sang Kim
Mol. Cells 2019; 42(12): 869-883  https://doi.org/10.14348/molcells.2019.0188 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells
Jin-Ah Park, Han-Heom Na, Hyeon-Ok Jin, and Keun-Cheol Kim
Mol. Cells 2019; 42(12): 884-892  https://doi.org/10.14348/molcells.2019.0088 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells
Rui-ting Long, Jun-bo Peng, Li-li Huang, Gui-ping Jiang, Yue-juan Liao, Hang Sun, Yu-dong Hu, and Xiao-hui Liao
Mol. Cells 2019; 42(12): 893-905  https://doi.org/10.14348/molcells.2019.0060 PDF PubMed PubMed Central PubReader Google Scholar Search
Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p
Feng-Bin Lu, Da-Zhi Chen, Lu Chen, En-De Hu, Jin-Lu Wu, Hui Li, Yue-Wen Gong, Zhuo Lin, Xiao-Dong Wang, Ji Li, Xiao-Ya Jin, Lan-Man Xu, and Yong-Ping Chen
Mol. Cells 2019; 42(12): 906-918  https://doi.org/10.14348/molcells.2019.2283 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
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Current Issue

31 December 2019
Volume 42,
Number 12,
pp. 821~918
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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