• Minireview  31 August 2021

    iPSC-Derived Natural Killer Cells for Cancer Immunotherapy

    The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the door to a new generation of regenerative medicine research. Among PSCs, the donors available for induced pluripotent stem cells (iPSCs) are greatest, providing a potentially universal cell source for all types of cell therapies including cancer immunotherapies using natural killer (NK cells). Unlike primary NK cells, those prepared from iPSCs can be prepared with a homogeneous quality and are easily modifi ...

  • Minireview  31 August 2021

    Molecular Mechanisms Underlying Motor Axon Guidance in Drosophila

    Decoding the molecular mechanisms underlying axon guidance is key to precise understanding of how complex neural circuits form during neural development. Although substantial progress has been made over the last three decades in identifying numerous axon guidance molecules and their functional roles, little is known about how these guidance molecules collaborate to steer growth cones to their correct targets. Recent studies in Drosophila point to the importance of the combinatorial action ...

  • Research Article  31 August 2021

    BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway

    Global knockout of the BK channel has been proven to affect bone formation; however, whether it directly affects osteoblast differentiation and the mechanism are elusive. In the current study, we further investigated the role of BK channels in bone development and explored whether BK channels impacted the differentiation and proliferation of osteoblasts via the canonical Wnt signaling pathway. Our findings demonstrated that knockout of Kcnma1 disrupted the osteogenesis of osteoblasts and inhibit ...

  • Research Article  31 August 2021

    Endoplasmic Reticulum Stress Induces CAP2 Expression Promoting Epithelial-Mesenchymal Transition in Liver Cancer Cells

    Cyclase-associated protein 2 (CAP2) has been addressed as a candidate biomarker in various cancer types. Previously, we have shown that CAP2 is expressed during multi-step hepatocarcinogenesis; however, its underlying mechanisms in liver cancer cells are not fully elucidated yet. Here, we demonstrated that endoplasmic reticulum (ER) stress induced CAP2 expression, and which promoted migration and invasion of liver cancer cells. We also found that the ER stress-induced ...

  • Research Article  31 August 2021

    Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells

    Patients with severe asthma have unmet clinical needs for effective and safe therapies. One possibility may be mesenchymal stem cell (MSC) therapy, which can improve asthma in murine models. However, it remains unclear how MSCs exert their beneficial effects in asthma. Here, we examined the effect of human umbilical cord blood-derived MSCs (hUC-MSC) on two mouse models of severe asthma, namely, Alternaria alternata-induced and house dust mite (HDM)/diesel exhaust particle (DEP)-induced asthma. h ...


Mol. Cells 2021; 44(8): 541~625
Minireviews
iPSC-Derived Natural Killer Cells for Cancer Immunotherapy
Peter Karagiannis and Shin-Il Kim
Mol. Cells 2021; 44(8): 541-548  https://doi.org/10.14348/molcells.2021.0078 PDF PubMed PubReader Google Scholar Search
Molecular Mechanisms Underlying Motor Axon Guidance in Drosophila
Sangyun Jeong
Mol. Cells 2021; 44(8): 549-556  https://doi.org/10.14348/molcells.2021.0129 PDF PubMed PubReader Google Scholar Search
Research Articles
BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway
Lan Jiang , Qianhong Yang , Jianjun Gao , Jiahong Yang , Jiaqi He , Hong Xin , and Xuemei Zhang
Mol. Cells 2021; 44(8): 557-568  https://doi.org/10.14348/molcells.2021.0004 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Endoplasmic Reticulum Stress Induces CAP2 Expression Promoting Epithelial-Mesenchymal Transition in Liver Cancer Cells
Sarah Yoon , Boram Shin , and Hyun Goo Woo
Mol. Cells 2021; 44(8): 569-579  https://doi.org/10.14348/molcells.2021.0031 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells
Jae Woo Shin , Seungwon Ryu , Jongho Ham , Keehoon Jung , Sangho Lee , Doo Hyun Chung , Hye-Ryun Kang , and Hye Young Kim
Mol. Cells 2021; 44(8): 580-590  https://doi.org/10.14348/molcells.2021.0101 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking
Julie J. Hong , Kyung Eun Kim , So Young Park , Jinwoong Bok , Jeong Taeg Seo , and Seok Jun Moon
Mol. Cells 2021; 44(8): 591-601  https://doi.org/10.14348/molcells.2021.0082 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
An Optimized Method for the Construction of a DNA Methylome from Small Quantities of Tissue or Purified DNA from Arabidopsis Embryo
Hyunjin Yoo , Kyunghyuk Park , Jaehoon Lee , Seunga Lee , and Yeonhee Choi
Mol. Cells 2021; 44(8): 602-612  https://doi.org/10.14348/molcells.2021.0084 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Retinoid Metabolism in the Degeneration of Pten-Deficient Mouse Retinal Pigment Epithelium
You-Joung Kim , Sooyeon Park , Taejeong Ha , Seungbeom Kim , Soyeon Lim , Han You , and Jin Woo Kim
Mol. Cells 2021; 44(8): 613-622  https://doi.org/10.14348/molcells.2021.0138 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Journal Club
Eyeless Worms Can Run Away from Dangerous Blues
Caenorhabditis elegans without conventional eyes are equipped with a color-detecting system that helps in avoiding blue pathogenic bacteria.

Gee-Yoon Lee and Seung-Jae V. Lee
Mol. Cells 2021; 44(8): 623-625  https://doi.org/10.14348/molcells.2021.0201 PDF PubMed PubReader Google Scholar Search
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Current Issue

31 August 2021
Volume 44,
Number 8,
pp. 541~625
COVER PICTURE Heart-stage embryo dissected from Arabidopsis seed (Yoo et al., pp. 602-612).
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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