• Research Article  31 January 2021

    Transforming Growth Factor β Inhibits MUC5AC Expression by Smad3/HDAC2 Complex Formation and NF-κB Deacetylation at K310 in NCI-H292 Cells

    Airway mucus secretion is an essential innate immune response for host protection. However, overproduction and hypersecretion of mucus, mainly composed of the gel- forming MUC5AC protein, are significant risk factors for patients with asthma and chronic obstructive pulmonary disease (COPD). The transforming growth factor β (TGFβ) signaling pathway negatively regulates MUC5AC expression; however, the underlying molecular mechanism is not fully understood. Here, we showed that TGFβ significantl ...

  • Research Article  31 January 2021

    Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster

    Apoptosis and compensatory proliferation, two intertwined cellular processes essential for both development and adult homeostasis, are often initiated by the mis-regulation of centrosomal proteins, damaged DNA, and defects in mitosis. Fly Anastral spindle 3 (Ana3) is a member of the pericentriolar matrix proteins and known as a key component of centriolar cohesion and basal body formation. We report here that ana3m19 is a suppressor of lethality induced by the overexpression of ...

  • Research Article  31 January 2021

    Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids

    Among all cancer types, lung cancer ranks highest worldwide in terms of both incidence and mortality. The crosstalk between lung cancer cells and their tumor microenvironment (TME) has begun to emerge as the “Achilles heel” of the disease and thus constitutes an attractive target for anticancer therapy. We previously revealed that crosstalk between lung cancer cells and endothelial cells (ECs) induces chemoresistance in multicellular tumor spheroids (MCTSs). In this study, we demonstrated th ...

  • Research Article  31 January 2021

    Molecular Analysis of the Interaction between Human PTPN21 and the Oncoprotein E7 from Human Papillomavirus Genotype 18

    Human papillomaviruses (HPVs) cause cellular hyperproliferation-associated abnormalities including cervical cancer. The HPV genome encodes two major viral oncoproteins, E6 and E7, which recruit various host proteins by direct interaction for proteasomal degradation. Recently, we reported the structure of HPV18 E7 conserved region 3 (CR3) bound to the protein tyrosine phosphatase (PTP) domain of PTPN14, a well-defined tumor suppressor, and found that this intermolecular interaction plays a key ro ...

  • Research Article  31 January 2021

    T-Cell Death Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis

    The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the master transcriptional regulator in adipogenesis. PPARγ forms a heterodimer with another nuclear receptor, retinoid X receptor (RXR), to form an active transcriptional complex, and their transcriptional activity is tightly regulated by the association with either coactivators or corepressors. In this study, we identified T-cell death-associated gene 51 (TDAG51) as a novel corepressor of PPARγ-mediated transcript ...


Mol. Cells 2021; 44(1): 1~62
Research Articles
T-Cell Death Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis
Sumi Kim , Nari Lee , Eui-Soon Park , Hyeongseok Yun , Tae-Uk Ha , Hyoeun Jeon , Jiyeon Yu , Seunga Choi , Bongjin Shin , Jungeun Yu , Sang Dal Rhee , Yongwon Choi , and Jaerang Rho
Mol. Cells 2021; 44(1): 1-12  https://doi.org/10.14348/molcells.2020.0143 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster
Dong-Gyu Cho , Sang-Soo Lee , and Kyung-Ok Cho
Mol. Cells 2021; 44(1): 13-25  https://doi.org/10.14348/molcells.2020.0244 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Molecular Analysis of the Interaction between Human PTPN21 and the Oncoprotein E7 from Human Papillomavirus Genotype 18
Hye Seon Lee , Min Wook Kim , Kyeong Sik Jin , Ho-Chul Shin , Won Kon Kim, Sang Chul Lee, Seung Jun Kim , Eun-Woo Lee , and Bonsu Ku
Mol. Cells 2021; 44(1): 26-37  https://doi.org/10.14348/molcells.2020.0169 PDF PubMed PubMed Central PubReader Google Scholar Search
Transforming Growth Factor β Inhibits MUC5AC Expression by Smad3/HDAC2 Complex Formation and NF-κB Deacetylation at K310 in NCI-H292 Cells
Su Ui Lee , Mun-Ock Kim , Myung-Ji Kang , Eun Sol Oh , Hyunju Ro , Ro Woon Lee , Yu Na Song , Sunin Jung , Jae-Won Lee , Soo Yun Lee , Taeyeol Bae , Sung-Tae Hong , and Tae-Don Kim
Mol. Cells 2021; 44(1): 38-49  https://doi.org/10.14348/molcells.2020.0188 PDF PubMed PubMed Central PubReader Google Scholar Search
Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids
Minji Lee , Yeonhwa Song , Inhee Choi , Su-Yeon Lee , Sanghwa Kim , Se-Hyuk Kim , Jiho Kim , and Haeng Ran Seo
Mol. Cells 2021; 44(1): 50-62  https://doi.org/10.14348/molcells.2020.0212 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
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Current Issue

31 January 2021
Volume 44,
Number 1,
pp. 1~62
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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