• Minireview  30 November 2018

    CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes

    The discovery and mechanistic understanding of target-specific genome engineering technologies has led to extremely effective and specific genome editing in higher organisms. Target-specific genetic modification technology is expected to have a leading position in future gene therapy development, and has a ripple effect on various basic and applied studies. However, several problems remain and hinder efficient and specific editing of target genomic loci. The issues are particularly critical i ...

  • Minireview  30 November 2018

    Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets

    Traditionally, small-molecule or antibody-based therapies against human diseases have been designed to inhibit the enzymatic activity or compete for the ligand binding sites of pathological target proteins. Despite its demonstrated effectiveness, such as in cancer treatment, this approach is often limited by recurring drug resistance. More importantly, not all molecular targets are enzymes or receptors with druggable ‘hot spots’ that can be directly occupied by active site-directed inhibi ...

  • Article  30 November 2018

    Laminar Flow Inhibits ER Stress-Induced Endothelial Apoptosis through PI3K/Akt-Dependent Signaling Pathway

    Atherosclerosis preferentially involves in prone area of low and disturbed blood flow while steady and high levels of laminar blood flow are relatively protected from atherosclerosis. Disturbed flow induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). ER stress is caused under stress that disturbs the processing and folding of proteins resulting in the accumulation of misfolded proteins in the ER and activation of the UPR. Prolonged or severe UPR leads to activat ...

  • Article  30 November 2018

    Dynamic Transcriptome, DNA Methylome, and DNA Hydroxymethylome Networks During T-Cell Lineage Commitment

    The stepwise development of T cells from a multipotent precursor is guided by diverse mechanisms, including interactions among lineage-specific transcription factors (TFs) and epigenetic changes, such as DNA methylation and hydroxymethylation, which play crucial roles in mammalian development and lineage commitment. To elucidate the transcriptional networks and epigenetic mechanisms underlying T-cell lineage commitment, we investigated genome-wide changes in gene expression, DNA methylation a ...


Mol. Cells 2018; 41(11): 933~992
Minireviews
Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets
Seonghyeon Moon, and Byung-Hoon Lee
Mol. Cells 2018; 41(11): 933-942  https://doi.org/10.14348/molcells.2018.0372 PDF PubReader Google Scholar Search
CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes
Seung Hwan Lee, Sunghyun Kim, and Junho K Hur
Mol. Cells 2018; 41(11): 943-952  https://doi.org/10.14348/molcells.2018.0408 PDF PubReader Google Scholar Search
Articles
Dynamic Transcriptome, DNA Methylome, and DNA Hydroxymethylome Networks During T-Cell Lineage Commitment
Byoung-Ha Yoon, Mirang Kim, Min-Hyeok Kim, Hee-Jin Kim, Jeong-Hwan Kim, Jong Hwan Kim, Jina Kim, Yong Sung Kim, Daeyoup Lee, Suk-Jo Kang, and Seon-Young Kim
Mol. Cells 2018; 41(11): 953-963  https://doi.org/10.14348/molcells.2018.0213 PDF PubReader Supplementary File(s) Google Scholar Search
Laminar Flow Inhibits ER Stress-Induced Endothelial Apoptosis through PI3K/Akt-Dependent Signaling Pathway
Suji Kim, and Chang-Hoon Woo
Mol. Cells 2018; 41(11): 964-970  https://doi.org/10.14348/molcells.2018.0111 PDF PubReader Google Scholar Search
Inhibition of MicroRNA-221 and 222 Enhances Hematopoietic Differentiation from Human Pluripotent Stem Cells via c-KIT Upregulation
Ji Yoon Lee, MyungJoo Kim, Hye-Ryeon Heo, Kwon-Soo Ha, Eun-Taek Han, Won Sun Park, Se-Ran Yang, and Seok-Ho Hong
Mol. Cells 2018; 41(11): 971-978  https://doi.org/10.14348/molcells.2018.0244 PDF PubReader Google Scholar Search
Transcriptome Profiling and Characterization of Drought-Tolerant Potato Plant (Solanum tuberosum L.)
Ki-Beom Moon, Dong-Joo Ahn, Ji-Sun Park, Won Yong Jung, Hye Sun Cho, Hye-Ran Kim, Jae-Heung Jeon, Youn-il Park, and Hyun-Soon Kim
Mol. Cells 2018; 41(11): 979-992  https://doi.org/10.14348/molcells.2018.0312 PDF PubReader Supplementary File(s) Google Scholar Search
  • e-Submission
    e-Submission Old System (~2016)  e-Submission (2017~) New System
  • For review & Editor
    e-Submission Old System (~2016)  e-Submission (2017~) New System

Current Issue

30 November 2018
Volume 41,
Number 11,
pp. 933~992
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


  • Science Central
  • CrossMark

Indexed in

This journal is indexed in Science Citation Index, Scopus, Current Contents®/Life Science, Sci-search®, Research Alert®, Index Medicus, Chemical Abstract Service, and PubMed.

Manuscript Submission

To submit a manuscript, please visit the Molecules and Cells e-submission management system at http://www.ksmcb.or.kr/submission/Login.html, read the Instructions to Authors, and log into the Molecules and Cells e-submission system. For assistance with manuscript submission, please contact: admin@molcells.org.