• Research Article  30 September 2019

    Upregulation of Carbonyl Reductase 1 by Nrf2 as a Potential Therapeutic Intervention for Ischemia/ Reperfusion Injury during Liver Transplantation

    Currently, liver transplantation is the only available remedy for patients with end-stage liver disease. Conservation of transplanted liver graft is the most important issue as it directly related to patient survival. Carbonyl reductase 1 (CBR1) protects cells against oxidative stress and cell death by inactivating cellular membrane-derived lipid aldehydes. Ischemia-reperfusion (I/R) injury during living-donor liver transplantation is known to form reactive oxygen species. Thus, the objective ...

  • Research Article  30 September 2019

    Small Molecule-Based Strategy Promotes Nucleus Pulposus Specific Differentiation of Adipose-Derived Mesenchymal Stem Cells

    Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising for regenerating degenerated intervertebral discs (IVDs), but the low efficiency of nucleus pulposus (NP)-specific differentiation limits their clinical applications. The Sonic hedgehog (Shh) signaling pathway is important in NP-specific differentiation of ADSCs, and Smoothened Agonist (SAG) is a highly specific and effective agonist of Shh signaling. In this study, we proposed a new differentiation strategy with the use of t ...

  • Research Article  30 September 2019

    Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling

    Abscisic acid (ABA) is a phytohormone essential for seed development and seedling growth under unfavorable environmental conditions. The signaling pathway leading to ABA response has been established, but relatively little is known about the functional regulation of the constituent signaling components. Here, we present several lines of evidence that Arabidopsis Raf-like kinase Raf10 modulates the core ABA signaling downstream of signal perception step. In particular, Raf10 phosphorylates sub ...

  • Research Article  30 September 2019

    Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells

    Altered genetic features in cancer cells lead to a high rate of aerobic glycolysis and metabolic reprogramming that is essential for increased cancer cell viability and rapid proliferation. Pyruvate kinase muscle (PKM) is a rate-limiting enzyme in the final step of glycolysis. Herein, we report that PKM is a potential therapeutic target in triple-negative breast cancer (TNBC) cells. We found that PKM1 or PKM2 is highly expressed in TNBC tissues or cells. Knockdown of PKM significantly suppres ...


Mol. Cells 2019; 42(9): 617~685
Minireview
Past, Present, and Future of Brain Organoid Technology
Bonsang Koo, Baekgyu Choi, Hoewon Park, and Ki-Jun Yoon
Mol. Cells 2019; 42(9): 617-627  https://doi.org/10.14348/molcells.2019.0162 PDF PubMed PubMed Central PubReader Google Scholar Search
Research Articles
Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells
Chaobing Ma, Xueyin Zu, Kangdong Liu, Ann M. Bode, Zigang Dong, Zhenzhen Liu, and Dong Joon Kim
Mol. Cells 2019; 42(9): 628-636  https://doi.org/10.14348/molcells.2019.0038 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Pi5 and Pii Paired NLRs Are Functionally Exchangeable and Confer Similar Disease Resistance Specificity
Kieu Thi Xuan Vo, Sang-Kyu Lee, Morgan K. Halane, Min-Young Song, Trung Viet Hoang, Chi-Yeol Kim, Sook-Young Park, Junhyun Jeon, Sun Tae Kim, Kee Hoon Sohn, and Jong-Seong Jeon
Mol. Cells 2019; 42(9): 637-645  https://doi.org/10.14348/molcells.2019.0070 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling
Quy Thi Cam Nguyen, Sun-ji Lee, Seo-wha Choi, Yeon-ju Na, Mi-ran Song, Quyen Thi Ngoc Hoang, Seo Young Sim, Min-Sik Kim, Jeong-Il Kim, Moon-Soo Soh, and Soo Young Kim
Mol. Cells 2019; 42(9): 646-660  https://doi.org/10.14348/molcells.2019.0173 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Small Molecule-Based Strategy Promotes Nucleus Pulposus Specific Differentiation of Adipose-Derived Mesenchymal Stem Cells
Jianming Hua, Ning Shen, Jingkai Wang, Yiqing Tao, Fangcai Li, Qixin Chen, and Xiaopeng Zhou
Mol. Cells 2019; 42(9): 661-671  https://doi.org/10.14348/molcells.2019.0098 PDF PubMed PubMed Central PubReader Google Scholar Search
Upregulation of Carbonyl Reductase 1 by Nrf2 as a Potential Therapeutic Intervention for Ischemia/ Reperfusion Injury during Liver Transplantation
Jae Hyun Kwon, Jooyoung Lee, Jiye Kim, Varvara A. Kirchner, Yong Hwa Jo, Takeshi Miura, Nayoung Kim, Gi-Won Song, Shin Hwang, Sung-Gyu Lee, Young-In Yoon, and Eunyoung Tak
Mol. Cells 2019; 42(9): 672-685  https://doi.org/10.14348/molcells.2019.0003 PDF PubMed PubMed Central PubReader Google Scholar Search
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Current Issue

30 September 2019
Volume 42,
Number 9,
pp. 617~685
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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