• Minireview  31 July 2018

    Structural Basis for LAR-RPTP–Mediated Synaptogenesis

    Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynaptic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP–mediated trans-synaptic adhesion complexe ...

  • Article  31 July 2018

    Self-Reprogramming of Spermatogonial Stem Cells into Pluripotent Stem Cells without Microenvironment of Feeder Cells

    Spermatogonial stem cells (SSCs) derived from mouse testis are unipotent in regard of spermatogenesis. Our previous study demonstrated that SSCs can be fully reprogrammed into pluripotent stem cells, so called germline-derived pluripotent stem cells (gPS cells), on feeder cells (mouse embryonic fibroblasts), which supports SSC proliferation and induction of pluripotency. Because of an uncontrollable microenvironment caused by interactions with feeder cells, feeder-based SSC reprogramming is n ...

  • Article  31 July 2018

    Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members

    Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a function ...

  • Minireview  31 July 2018

    Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations

    The capacity of differentiation of human pluripotent stem cells (hPSCs), which include both embryonic stem cells and induced pluripotent stem cells, into cardiomyocytes (CMs) in vitro provides an unlimited resource for human CMs for a wide range of applications such as cell based cardiac repair, cardiac drug toxicology screening, and human cardiac disease modeling. However, their applicability is significantly limited by immature phenotypes. It has been well known that curren ...

Mol. Cells 2018; 41(9): 809~880
Synergistic Ensemble of Optogenetic Actuators and Dynamic Indicators in Cell Biology
Jihoon Kim, and Won Do Heo
Mol. Cells 2018; 41(9): 809-817  https://doi.org/10.14348/molcells.2018.0295 PDF PubMed PubReader Google Scholar Search
RNA-Binding Proteins in Amyotrophic Lateral Sclerosis
Melody Zhao, Jihye Rachel Kim, Rebekah van Bruggen, and Jeehye Park
Mol. Cells 2018; 41(9): 818-829  https://doi.org/10.14348/molcells.2018.0243 PDF PubMed PubReader Google Scholar Search
MicroRNA-766-3p Inhibits Tumour Progression by Targeting Wnt3a in Hepatocellular Carcinoma
Yu You, Keting Que, Yun Zhou, Zhen Zhang, Xiaoping Zhao, Jianpin Gong, and Zuojin Liu
Mol. Cells 2018; 41(9): 830-841  https://doi.org/10.14348/molcells.2018.0181 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor
Gwang Sik Kim, Hee-Sae Park, and Young Chul Lee
Mol. Cells 2018; 41(9): 842-852  https://doi.org/10.14348/molcells.2018.0196 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
SDC4 Gene Silencing Favors Human Papillary Thyroid Carcinoma Cell Apoptosis and Inhibits Epithelial Mesenchymal Transition via Wnt/β-Catenin Pathway
Liang-Liang Chen, Ge-Xin Gao, Fei-Xia Shen, Xiong Chen, Xiao-Hua Gong, and Wen-Jun Wu
Mol. Cells 2018; 41(9): 853-867  https://doi.org/10.14348/molcells.2018.0103 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
EZH2-Mediated microRNA-139-5p Regulates Epithelial-Mesenchymal Transition and Lymph Node Metastasis of Pancreatic Cancer
Jin Ma, Jun Zhang, Yuan-Chi Weng, and Jian-Cheng Wang
Mol. Cells 2018; 41(9): 868-880  https://doi.org/10.14348/molcells.2018.0109 PDF PubMed PubReader Google Scholar Search
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Current Issue

30 September 2018
Volume 41,
Number 9,
pp. 809~880
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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