• Article  31 May 2018

    Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption

    Although tectorigenin (TG), a major compound in the rhizome of Belamcanda chinensis, is conventionally used for the treatment of inflammatory diseases, its effects on osteogenesis and osteoclastogenesis have not been reported. The objective of this study was to investigate the effects and possible underlying mechanism of TG on in vitro osteoblastic differentiation and in vivo bone formation, as well as in vitro osteoclast dif ...

  • Article  31 May 2018

    Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 Cells

    Oxymatrine (OMT) often used in treatment for chronic hepatitis B virus infection in clinic. However, OMT–induced liver injury has been reported. In this study, we aim to investigate the possible mechanism of OMT-induced hepatotoxicity in human normal liver cells (L02). Exposed cells to OMT, the cell viability was decreased and apoptosis rate increased, the intracellular markers of oxidative stress were changed. Simultaneously, OMT altered apoptotic related proteins levels, including Bcl-2, ...

  • Minireview  31 May 2018

    Regulatory Network of ARF in Cancer Development

    ARF is a tumor suppressor protein that has a pivotal role in the prevention of cancer development through regulating cell proliferation, senescence, and apoptosis. As a factor that induces senescence, the role of ARF as a tumor suppressor is closely linked to the p53-MDM2 axis, which is a key process that restrains tumor formation. Thus, many cancer cells either lack a functional ARF or p53, which enables them to evade cell oncogenic stress-mediated cycle arrest, senescence, or apoptosis. In ...

  • Minireview  31 May 2018

    Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers

    Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific syn ...


Mol. Cells 2018; 41(6): 495~611
Minireviews
Current Challenges of Streptococcus Infection and Effective Molecular, Cellular, and Environmental Control Methods in Aquaculture
Anshuman Mishra, Gyu-Hwi Nam, Jeong-An Gim, Hee-Eun Lee, Ara Jo, and Heui-Soo Kim
Mol. Cells 2018; 41(6): 495-505  https://doi.org/10.14348/molcells.2018.2154 PDF PubMed Google Scholar Search
Targeting Super-Enhancers for Disease Treatment and Diagnosis
Ha Youn Shin
Mol. Cells 2018; 41(6): 506-514  https://doi.org/10.14348/molcells.2018.2297 PDF PubMed Google Scholar Search
Research Articles
Characterization of Primary Epithelial Cells Derived from Human Salivary Gland Contributing
to in vivo Formation of Acini-like Structures
Hyun Nam, Ji-Hye Kim, Ji-Yoon Hwang, Gee-Hye Kim, Jae-Won Kim, Mi Jang, Jong-Ho Lee,
Kyungpyo Park, and Gene Lee
Mol. Cells 2018; 41(6): 515-522  https://doi.org/10.14348/molcells.2018.0060 PDF PubMed Google Scholar Search
MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1
Gen Li, Li Li, Qi Sun, Jiezhou Wu, Wei Ge, Guanghua Lu, and Ming Cai
Mol. Cells 2018; 41(6): 523-531  https://doi.org/10.14348/molcells.2018.2200 PDF PubMed Google Scholar Search
MiR-374b Promotes Proliferation and Inhibits Apoptosis of Human GIST Cells by Inhibiting PTEN through Activation of the PI3K/Akt Pathway
Zi-Wen Long, Jiang-Hong Wu, Cai- Hong, Ya-Nong Wang, and Ye Zhou
Mol. Cells 2018; 41(6): 532-544  https://doi.org/10.14348/molcells.2018.2211 PDF PubMed Google Scholar Search
Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors
Sang Jae Lee, Jang-Sik Choi, Seoung Min Bong, Hae-Jun Hwang, Jaesang Lee, Ho-Juhn Song,
Jaekyoo Lee, Jung-Ho Kim, Jong Sung Koh, and Byung Il Lee
Mol. Cells 2018; 41(6): 545-552  https://doi.org/10.14348/molcells.2018.2219 PDF PubMed Google Scholar Search
Icariside II Promotes the Differentiation of Adipose Tissue-Derived Stem Cells to Schwann Cells to Preserve Erectile Function after Cavernous Nerve Injury
Tao Zheng, Tian-biao Zhang, Chao-liang Wang, Wei-xing Zhang, Dong-hui Jia, Fan Yang,
Yang-yang Sun, Xiao-ju Ding, and Rui Wang
Mol. Cells 2018; 41(6): 553-561  https://doi.org/10.14348/molcells.2018.2236 PDF PubMed Google Scholar Search
Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells
Chun-Hua Wang, Rong-Yaun Shyu, Chang-Chieh Wu, Mao-Liang Chen, Ming-Cheng Lee,
Yi-Yin Lin, Lu-Kai Wang, Shun-Yuan Jiang, and Fu-Ming Tsai
Mol. Cells 2018; 41(6): 562-574  https://doi.org/10.14348/molcells.2018.2347 PDF PubMed Google Scholar Search
TNF-α-Induced SOX5 Upregulation Is Involved in the Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Through KLF4 Signal Pathway
Lijun Xu, Lili Zheng, Zhifang Wang, Chong Li, Shan Li, Xuedi Xia, Pengyan Zhang, Li Li, and
Lixia Zhang
Mol. Cells 2018; 41(6): 575-581  https://doi.org/10.14348/molcells.2018.2359 PDF PubMed Google Scholar Search
Long-Term Priming by Three Small Molecules Is a Promising Strategy for Enhancing Late Endothelial Progenitor Cell Bioactivities
Yeon-Ju Kim, Seung Taek Ji, Da Yeon Kim, Seok Yun Jung, Songhwa Kang, Ji Hye Park,
Woong Bi Jang, Jisoo Yun, Jongseong Ha, Dong Hyung Lee, and Sang-Mo Kwon
Mol. Cells 2018; 41(6): 582-590  https://doi.org/10.14348/molcells.2018.0011 PDF PubMed Google Scholar Search
Validation of Neurotensin Receptor 1 as a Therapeutic Target for Gastric Cancer
Hafeza Akter, Jung Hwan Yoon, Young Sook Yoo, and Min-Jung Kang
Mol. Cells 2018; 41(6): 591-602  https://doi.org/10.14348/molcells.2018.0025 PDF PubMed Google Scholar Search
Flightless-I Controls Fat Storage in Drosophila
Jung-Eun Park, Eun Ji Lee, Jung Kwan Kim, Youngsup Song, Jang Hyun Choi, and Min-Ji Kang
Mol. Cells 2018; 41(6): 603-611  https://doi.org/10.14348/molcells.2018.0120 PDF PubMed Google Scholar Search
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Current Issue

30 June 2018
Volume 41,
Number 6,
pp. 495~611
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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