• Research Article  31 December 2020

    Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1

    The Drosophila genome contains four low molecular weightprotein tyrosine phosphatase (LMW-PTP) members: Primo-1, Primo-2, CG14297, and CG31469. The lack of intensive biochemical analysis has limited our understanding of these proteins. Primo-1 and CG31469 were previously classified as pseudophosphatases, but CG31469 was also suggested to be a putative protein arginine phosphatase. Herein, we present the crystal structures of CG31469 and Primo-1, which are the first Drosophila LMW-P ...

  • Research Article  31 December 2020

    Moieties of Complement iC3b Recognized by the I-domain of Integrin αXβ2

    Complement fragment iC3b serves as a major opsonin for facilitating phagocytosis via its interaction with complement receptors CR3 and CR4, also known by their leukocyte integrin family names, αMβ2 and αXβ2, respectively. Although there is general agreement that iC3b binds to the αM and αX I-domains of the respective β2-integrins, much less is known regarding the regions of iC3b contributing to the αX I-domain binding. In this study, using recombinant αX I-domain, as well as recombinant ...

  • Research Article  31 December 2020

    NEUROD1 Intrinsically Initiates Differentiation of Induced Pluripotent Stem Cells into Neural Progenitor Cells

    Cell type specification is a delicate biological event in which every step is under tight regulation. From a molecular point of view, cell fate commitment begins with chromatin alteration, which kickstarts lineage-determining factors to initiate a series of genes required for cell specification. Several important neuronal differentiation factors have been identified from ectopic over-expression studies. However, there is scarce information on which DNA regions are modified during induced pluripo ...

  • Research Article  31 December 2020

    Sub-Ciliary Segregation of Two Drosophila Transient Receptor Potential Channels Begins at the Initial Stage of Their Pre-Ciliary Trafficking

    Cilia are important eukaryotic cellular compartments required for diverse biological functions. Recent studies have revealed that protein targeting into the proper ciliary subcompartments is essential for ciliary function. In Drosophila chordotonal cilium, where mechano-electric transduction occurs, two transient receptor potential (TRP) superfamily ion channels, TRPV and TRPN, are restricted to the proximal and distal subcompartments, respectively. To understand the mechanisms underlying ...

  • Research Article  31 December 2020

    Lysophosphatidylcholine Enhances Bactericidal Activity by Promoting Phagosome Maturation via the Activation of the NF-κB Pathway during Salmonella Infection in Mouse Macrophages

    Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular pathogen that causes salmonellosis and mortality worldwide. S. Typhimurium infects macrophages and survives within phagosomes by avoiding the phagosome-lysosome fusion system. Phagosomes sequentially acquire different Rab GTPases during maturation and eventually fuse with acidic lysosomes. Lysophosphatidylcholine (LPC) is a bioactive lipid that is associated with the generation of chemoattractants and ...


Mol. Cells 2020; 43(12): 975~1045
Research Articles
Long Noncoding RNA Expression Profiling Reveals Upregulation of Uroplakin 1A and Uroplakin 1A Antisense RNA 1 under Hypoxic Conditions in Lung Cancer Cells
Yuree Byun , Young-Chul Choi , Yongsu Jeong , Jaeseung Yoon , and Kwanghee Baek
Mol. Cells 2020; 43(12): 975-988  https://doi.org/10.14348/molcells.2020.0126 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
Lysophosphatidylcholine Enhances Bactericidal Activity by Promoting Phagosome Maturation via the Activation of the NF-κB Pathway during Salmonella Infection in Mouse Macrophages
Hyo-Ji Lee , Wan-Gi Hong , Yunseo Woo , Jae-Hee Ahn , Hyun-Jeong Ko , Hyeran Kim , Sungjin Moon , Tae-Wook Hahn , Young Mee Jung , Dong-Keun Song , and Yu-Jin Jung
Mol. Cells 2020; 43(12): 989-1001  https://doi.org/10.14348/molcells.2020.0030 PDF PubMed PubMed Central Google Scholar Search
Sub-Ciliary Segregation of Two Drosophila Transient Receptor Potential Channels Begins at the Initial Stage of Their Pre-Ciliary Trafficking
Youngtae Kwon , Jeongmi Lee , and Yun Doo Chung
Mol. Cells 2020; 43(12): 1002-1010  https://doi.org/10.14348/molcells.2020.0205 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
NEUROD1 Intrinsically Initiates Differentiation of Induced Pluripotent Stem Cells into Neural Progenitor Cells
Won-Young Choi , Ji-Hyun Hwang , Ann-Na Cho , Andrew J. Lee , Inkyung Jung , Seung-Woo Cho , Lark Kyun Kim , and Young-Joon Kim
Mol. Cells 2020; 43(12): 1011-1022  https://doi.org/10.14348/molcells.2020.0207 PDF PubMed PubMed Central Google Scholar Search
Moieties of Complement iC3b Recognized by the I-domain of Integrin αXβ2
Jeongsuk Choi , Dolgorsuren Buyannemekh, and Sang-Uk Nham
Mol. Cells 2020; 43(12): 1023-1034  https://doi.org/10.14348/molcells.2020.0197 PDF PubMed PubMed Central Google Scholar Search
Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1
Hye Seon Lee , Yeajin Mo, Ho-Chul Shin , Seung Jun Kim , and Bonsu Ku
Mol. Cells 2020; 43(12): 1035-1045  https://doi.org/10.14348/molcells.2020.0192 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
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Current Issue

31 December 2020
Volume 43,
Number 12,
pp. 975~1045
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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