• Minireview  29 February 2020

    Role of RUNX Family Members in G1 Restriction-Point Regulation

    When cells are stimulated by growth factors, they make a critical choice in early G1 phase: proceed forward to S phase, remain in G1, or revert to G0 phase. Once the critical decision is made, cells execute a fixed program independently of extracellular signals. The specific stage at which the critical decision is made is called the restriction point or R-point. The existence of the R-point raises a major question: what is the nature of the molecular machinery th ...

  • Minireview  29 February 2020

    RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia

    Somatic RUNX1 mutations are found in approximately 10% of patients with de novo acute myeloid leukemia (AML), but are more common in secondary forms of myelodysplastic syndrome (MDS) or AML. Particularly, this applies to MDS/AML developing from certain types of leukemia-prone inherited bone marrow failure syndromes. How these RUNX1 mutations contribute to the pathobiology of secondary MDS/AML is still unknown. This mini-review focusses on the role of RUNX1 mutations as the m ...

  • Minireview  29 February 2020

    The Role of Lozenge in Drosophila Hematopoiesis

    Drosophila hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of Drosophila genetics. A Runt domain protein, lozenge, is one of the first players recognized and closely studied in the hematopoietic lineage specification. Here, we explore the role of lozenge in determina ...

  • Minireview  29 February 2020

    Role of RUNX Family Transcription Factors in DNA Damage Response

    Cells are constantly exposed to endogenous and exogenous stresses that can result in DNA damage. In response, they have evolved complex pathways to maintain genomic integrity. RUNX family transcription factors (RUNX1, RUNX2, and RUNX3 in mammals) are master regulators of development and differentiation, and are frequently dysregulated in cancer. A growing body of research also implicates RUNX proteins as regulators of the DNA damage response, often acting in conjunction with the p53 and Fanconi ...

Mol. Cells 2020; 43(3): 203~311
Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders
Soumyadip Das , Suresh Ramakrishna , and Kye-Seong Kim
Mol. Cells 2020; 43(3): 203-214  https://doi.org/10.14348/molcells.2020.2289 PDF PubMed Google Scholar Search
Distinct Developmental Features of Olfactory Bulb Interneurons
Jae Yeon Kim , Jiyun Choe , and Cheil Moon
Mol. Cells 2020; 43(3): 215-221  https://doi.org/10.14348/molcells.2020.0033 PDF PubMed Google Scholar Search
Rapid Report
Identification of the Antidepressant Vilazodone as an Inhibitor of Inositol Polyphosphate Multikinase by Structure-Based Drug Repositioning
Boah Lee , Seung Ju Park , Seulgi Lee , Seung Eun Park , Eunhye Lee , Ji-Joon Song , Youngjoo Byun , and Seyun Kim
Mol. Cells 2020; 43(3): 222-227  https://doi.org/10.14348/molcells.2020.0051 PDF PubMed Supplementary File(s) Google Scholar Search
Research Articles
Identification of cis -Regulatory Region Controlling Semaphorin-1a Expression in the Drosophila Embryonic Nervous System
Young Gi Hong , Bongsu Kang , Seongsoo Lee , Youngseok Lee , Bong-Gun Ju , and Sangyun Jeong
Mol. Cells 2020; 43(3): 228-235  https://doi.org/10.14348/molcells.2019.0294 PDF PubMed Supplementary File(s) Google Scholar Search
Inhibitory Role of TRIP-Br1/XIAP in Necroptosis under Nutrient/Serum Starvation
Zolzaya Sandag , Samil Jung , Nguyen Thi Ngoc Quynh , Davaajargal Myagmarjav , Nguyen Hai Anh , Dan-Diem Thi Le , Beom Suk Lee , Raj Kumar Mongre , Taeyeon Jo , and MyeongSok Lee
Mol. Cells 2020; 43(3): 236-250  https://doi.org/10.14348/molcells.2020.2193 PDF PubMed Google Scholar Search
Flagellin-Stimulated Production of Interferon-β Promotes Anti-Flagellin IgG2c and IgA Responses
Wondae Kang , Areum Park , Ji-Won Huh , Gihoon You , Da-Jung Jung , Manki Song , Heung Kyu Lee , and You-Me Kim
Mol. Cells 2020; 43(3): 251-263  https://doi.org/10.14348/molcells.2020.2300 PDF PubMed Supplementary File(s) Google Scholar Search
Reduced EGFR Level in eIF2α Phosphorylation-Deficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress
Mi-Jeong Kim , Woo-Gyun Choi , Kyung-Ju Ahn , In Gyeong Chae , Rina Yu , and Sung Hoon Back
Mol. Cells 2020; 43(3): 264-275  https://doi.org/10.14348/molcells.2020.2197 PDF PubMed Supplementary File(s) Google Scholar Search
Gut Microbial Metabolites Induce Changes in Circadian Oscillation of Clock Gene Expression in the Mouse Embryonic Fibroblasts
Kyojin Ku , Inah Park, Doyeon Kim , Jeongah Kim, Sangwon Jang, Mijung Choi, Han Kyoung Choe , and Kyungjin Kim
Mol. Cells 2020; 43(3): 276-285  https://doi.org/10.14348/molcells.2020.2309 PDF PubMed Google Scholar Search
Interaction of the Lysophospholipase PNPLA7 with Lipid Droplets through the Catalytic Region
Pingan Chang , Tengteng Sun , Christoph Heier , Hao Gao , Hongmei Xu , and Feifei Huang
Mol. Cells 2020; 43(3): 286-297  https://doi.org/10.14348/molcells.2020.2283 PDF PubMed Google Scholar Search
Real-Time Measurement of the Liquid Amount in Cryo-Electron Microscopy Grids Using Laser Diffraction of Regular 2-D Holes of the Grids
Jinsook Ahn , Dukwon Lee , Inseong Jo , Hyeongseop Jeong , Jae-Kyung Hyun , Jae-Sung Woo , Sang-Ho Choi , and Nam-Chul Ha
Mol. Cells 2020; 43(3): 298-303  https://doi.org/10.14348/molcells.2020.2238 PDF PubMed Supplementary File(s) Google Scholar Search
Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila
Yoon Seok Suh , Eunbyul Yeom , Jong-Woo Nam, Kyung-Jin Min , Jeongsoo Lee , and Kweon Yu
Mol. Cells 2020; 43(3): 304-311  https://doi.org/10.14348/molcells.2019.0273 PDF PubMed Supplementary File(s) Google Scholar Search
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Current Issue

31 March 2020
Volume 43,
Number 3,
pp. 203~311
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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