• Research Article  30 April 2020

    Biological Functions and Identification of Novel Biomarker Expressed on the Surface of Breast Cancer-Derived Cancer Stem Cells via Proteomic Analysis

    Breast cancer is one of the most common life-threatening malignancies and the top cause of cancer deaths in women. Although many conventional therapies exist for its treatment, breast cancer still has many handicaps to overcome. Cancer stem cells (CSCs) are a well-known cause of tumor recurrences due to the ability of CSCs for self-renewal and differentiation into cell subpopulations, similar to stem cells. To fully treat breast cancer, a strategy for the treatment of both cancer cells and CSCs ...

  • Research Article  30 April 2020

    Structural Basis for the Antibiotic Resistance of Eukaryotic Isoleucyl-tRNA Synthetase

    Pathogenic aminoacyl-tRNA synthetases (ARSs) are attractive targets for anti-infective agents because their catalytic active sites are different from those of human ARSs. Mupirocin is a topical antibiotic that specifically inhibits bacterial isoleucy-ltRNA synthetase (IleRS), resulting in a block to protein synthesis. Previous studies on Thermus thermophilus IleRS indicated that mupirocin-resistance of eukaryotic IleRS is primarily due to differences in two amino acids, His581 and Leu583, ...

  • Rapid Report  30 April 2020

    Accelerated Evolution of the Regulatory Sequences of Brain Development in the Human Genome

    Genetic modifications in noncoding regulatory regions are likely critical to human evolution. Human-accelerated noncoding elements are highly conserved noncoding regions among vertebrates but have large differences across humans, which implies human-specific regulatory potential. In this study, we found that human-accelerated noncoding elements were frequently coupled with DNase I hypersensitive sites (DHSs), together with monomethylated and trimethylated histone H3 lysine 4, which are active re ...

  • Minireview  30 April 2020

    Zinc and Its Transporters in Epigenetics

    Epigenetic events like DNA methylation and histone modification can alter heritable phenotypes. Zinc is required for the activity of various epigenetic enzymes, such as DNA methyltransferases (DNMTs), histone acetyltransferases (HATs), histone deacetylases (HDACs), and histone demethylases, which possess several zinc binding sites. Thus, the dysregulation of zinc homeostasis can lead to epigenetic alterations. Zinc homeostasis is regulated by Zinc Transporters (ZnTs), Zrt- and Irt-like proteins ...


Mol. Cells 2020; 43(4): 313~418
Minireviews
Functions of the Plant Qbc SNARE SNAP25 in Cytokinesis and Biotic and Abiotic Stress Responses
Kang-Hee Won and Hyeran Kim
Mol. Cells 2020; 43(4): 313-322  https://doi.org/10.14348/molcells.2020.2245 PDF PubMed PubMed Central Google Scholar Search
Zinc and Its Transporters in Epigenetics
Sofia Brito , Mi-Gi Lee , Bum-Ho Bin , and Jong-Soo Lee
Mol. Cells 2020; 43(4): 323-330  https://doi.org/10.14348/molcells.2020.0026 PDF PubMed PubMed Central Google Scholar Search
Rapid Report
Accelerated Evolution of the Regulatory Sequences of Brain Development in the Human Genome
Kang Seon Lee , Hyoeun Bang , Jung Kyoon Choi , and Kwoneel Kim
Mol. Cells 2020; 43(4): 331-339  https://doi.org/10.14348/molcells.2020.2282 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
Research Articles
Oleoylethanolamide Exhibits GPR119-Dependent Inhibition of Osteoclast Function and GPR119-Independent Promotion of Osteoclast Apoptosis
Hyun-Ju Kim , Dong-Kyo Lee , Xian Jin , Xiangguo Che , and Je-Yong Choi
Mol. Cells 2020; 43(4): 340-349  https://doi.org/10.14348/molcells.2020.2260 PDF PubMed PubMed Central Google Scholar Search
Structural Basis for the Antibiotic Resistance of Eukaryotic Isoleucyl-tRNA Synthetase
Scisung Chung , Sulhee Kim , Sung Ho Ryu , Kwang Yeon Hwang , and Yunje Cho
Mol. Cells 2020; 43(4): 350-359  https://doi.org/10.14348/molcells.2020.2287 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice
Young Lee , Na-Eun Han , Wonju Kim , Jae Gon Kim , In Bum Lee , Su Jeong Choi , Heejung Chun , Misun Seo , C. Justin Lee , Hae-Young Koh , Joung-Hun Kim , Ja-Hyun Baik , Mark F. Bear , Se-Young Choi , and Bong-June Yoon
Mol. Cells 2020; 43(4): 360-372  https://doi.org/10.14348/molcells.2019.0279 PDF PubMed PubMed Central Google Scholar Search
FADD Phosphorylation Modulates Blood Glucose Levels by Decreasing the Expression of Insulin-Degrading Enzyme
Yan Lin , Jia Liu , Jia Chen , Chun Yao , Yunwen Yang , Jie Wang , Hongqin Zhuang , and Zi-Chun Hua
Mol. Cells 2020; 43(4): 373-383  https://doi.org/10.14348/molcells.2020.2198 PDF PubMed PubMed Central Google Scholar Search
Biological Functions and Identification of Novel Biomarker Expressed on the Surface of Breast Cancer-Derived Cancer Stem Cells via Proteomic Analysis
Eun-Young Koh , Ji-Eun You , Se-Hwa Jung , and Pyung-Hwan Kim
Mol. Cells 2020; 43(4): 384-396  https://doi.org/10.14348/molcells.2020.2230 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation
Hyeon Ju Lee , Yu-Jin Jung , Seungkoo Lee , Jong-Il Kim , and Jeong A. Han
Mol. Cells 2020; 43(4): 397-407  https://doi.org/10.14348/molcells.2020.2231 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
Molecular Signatures of Sinus Node Dysfunction Induce Structural Remodeling in the Right Atrial Tissue
Seung-Young Roh , Ji Yeon Kim , Hyo Kyeong Cha , Hye Young Lim , Youngran Park , Kwang-No Lee , Jaemin Shim , Jong-Il Choi , Young-Hoon Kim , and Gi Hoon Son
Mol. Cells 2020; 43(4): 408-418  https://doi.org/10.14348/molcells.2020.2164 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
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Current Issue

30 April 2020
Volume 43,
Number 4,
pp. 313~418
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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