• Minireview  30 September 2021

    Visualizing Live Chromatin Dynamics through CRISPR-Based Imaging Techniques

    The three-dimensional organization of chromatin and its time-dependent changes greatly affect virtually every cellular function, especially DNA replication, genome maintenance, transcription regulation, and cell differentiation. Sequencing-based techniques such as ChIP-seq, ATAC-seq, and Hi-C provide abundant information on how genomic elements are coupled with regulatory proteins and functionally organized into hierarchical domains through their interactions. However, visualizing the time-depen ...

  • Research Article  30 September 2021

    An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial β-Oxidation in C2C12 Myotubes

    Free fatty acids are converted to acyl-CoA by long-chain acyl-CoA synthetases (ACSLs) before entering into metabolic pathways for lipid biosynthesis or degradation. ACSL family members have highly conserved amino acid sequences except for their N-terminal regions. Several reports have shown that ACSL1, among the ACSLs, is located in mitochondria and mainly leads fatty acids to the β-oxidation pathway in various cell types. In this study, we investigated how ACSL1 was localized in mitochondria a ...

  • Research Article  30 September 2021

    Identification and Functional Characterization of Two Noncoding RNAs Transcribed from Putative Active Enhancers in Hepatocellular Carcinoma

    Enhancers have been conventionally perceived as cis-acting elements that provide binding sites for trans-acting factors. However, recent studies have shown that enhancers are transcribed and that these transcripts, called enhancer RNAs (eRNAs), have a regulatory function. Here, we identified putative eRNAs by profiling and determining the overlap between noncoding RNA expression loci and eRNA-associated histone marks such as H3K27ac and H3K4me1 in hepatocellular carcinoma (HCC) cel ...

  • Research Article  30 September 2021

    Regional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates

    Coronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in European countries than in others, especially East Asian ones. One potential explanation for this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene, a key enzyme essential for viral infection and fou ...

  • Research Article  30 September 2021

    Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation

    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a global health concern. Various SARS-CoV-2 vaccines have been developed and are being used for vaccination worldwide. However, no therapeutic agents against coronavirus disease 2019 (COVID-19) have been developed so far; therefore, new therapeutic agents are urgently needed. In the present study, we evaluated several hepatitis C virus direct-acting antivirals as potential candidates for drug repurposing against ...


Mol. Cells 2021; 44(9): 627~698
Minireview
Visualizing Live Chromatin Dynamics through CRISPR-Based Imaging Techniques
Narendra Chaudhary , Jae-Kyeong Im , Si-Hyeong Nho , and Hajin Kim
Mol. Cells 2021; 44(9): 627-636  https://doi.org/10.14348/molcells.2021.2254 PDF PubMed PubMed Central Google Scholar Search
Research Articles
An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial β-Oxidation in C2C12 Myotubes
Jinyan Nan , Ji Seon Lee , Seung-Ah Lee , Dong-Sup Lee , Kyong Soo Park , and Sung Soo Chung
Mol. Cells 2021; 44(9): 637-646  https://doi.org/10.14348/molcells.2021.0077 PDF PubMed PubMed Central Google Scholar Search
Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression
Jie Guo , Mengfan Liao , Xianmin Hu , and Jun Wang
Mol. Cells 2021; 44(9): 647-657  https://doi.org/10.14348/molcells.2021.0145 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
Identification and Functional Characterization of Two Noncoding RNAs Transcribed from Putative Active Enhancers in Hepatocellular Carcinoma
Ye-Eun Lee , Jiyeon Lee , Yong Sun Lee , Jiyoung Joan Jang , Hyeonju Woo , Hae In Choi , Young Gyu Chai , Tae-Kyung Kim , TaeSoo Kim , Lark Kyun Kim , and Sun Shim Choi
Mol. Cells 2021; 44(9): 658-669  https://doi.org/10.14348/molcells.2021.0173 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
Synaptotagmin 5 Controls SYP132-VAMP721/722 Interaction for Arabidopsis Immunity to Pseudomonas syringae pv tomato DC3000
Soohong Kim , Hyeran Kim , Keunchun Park , Da Jeong Cho , Mi Kyung Kim , Chian Kwon , and Hye Sup Yun
Mol. Cells 2021; 44(9): 670-679  https://doi.org/10.14348/molcells.2021.0100 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
Regional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates
Sungwon Jeon , Asta Blazyte , Changhan Yoon , Hyojung Ryu , Yeonsu Jeon , Youngjune Bhak , Dan Bolser , Andrea Manica , Eun-Seok Shin , Yun Sung Cho , Byung Chul Kim , Namhee Ryoo , Hansol Choi , and Jong Bhak
Mol. Cells 2021; 44(9): 680-687  https://doi.org/10.14348/molcells.2021.2249 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation
Yun-Sook Lim , Lap P. Nguyen , Gun-Hee Lee , Sung-Geun Lee , Kwang-Soo Lyoo , Bumseok Kim , and Soon B. Hwang
Mol. Cells 2021; 44(9): 688-695  https://doi.org/10.14348/molcells.2021.0076 PDF PubMed PubMed Central Google Scholar Search
Journal Club
Sure, Fathers Give Birth, Too!
Postnatal paternal folate deficiency increases congenital disabilities through H3K4me3
histone methylation changes in sperm and embryos.

Sun-Kyung Lee *
Mol. Cells 2021; 44(9): 696-698  https://doi.org/10.14348/molcells.2021.0202 PDF PubMed PubMed Central Google Scholar Search
  • e-Submission
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Current Issue

30 September 2021
Volume 44,
Number 9,
pp. 627~698
COVER PICTURE Non-mitochondrial localization of the N-terminal-deleted mutant form of ACSL1 in Cos7 cells. Green, ACSL1 mutant; Red, mitotracker; Blue, DAPI (Nan et al., pp. 637-646).
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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