• Article  30 November 2016

    Allele-Specific Phenotype Suggests a Possible Stimulatory Activity of RCAN-1 on Calcineurin in Caenorhabditis elegans

    Regulator of calcineurin 1 (RCAN1) binds to calcineurin through the PxIxIT motif, which is evolutionarily conserved. SP repeat phosphorylation in RCAN1 is required for its complete function. The specific interaction between RCAN1 and calcineurin is critical for calcium/calmodulin-dependent regulation of calcineurin serine/threonine phosphatase activity. In this study, we investigated two available deletion rcan-1 mutants in Caenorhabditis elegans, which proce ...

  • Article  30 November 2016

    Structural and Biochemical Studies Reveal a Putative FtsZ Recognition Site on the Z-ring Stabilizer ZapD

    FtsZ, a tubulin homologue, is an essential protein of the Z-ring assembly in bacterial cell division. It consists of two domains, the N-terminal and C-terminal core domains, and has a conserved C-terminal tail region. Lateral interactions between FtsZ protofilaments and several Z-ring associated proteins (Zaps) are necessary for modulating Z-ring formation. ZapD, one of the positive regulators of Z-ring assembly, directly binds to the C-terminal tail of FtsZ and promotes stable Z-ring formati ...

  • Minireview  30 November 2016

    Epigenetic Changes in Neurodegenerative Diseases

    Afflicted neurons in various neurodegenerative diseases generally display diverse and complex pathological features before catastrophic occurrence of massive neuronal loss at the late stages of the diseases. This complex nature of neuronal pathophysiology inevitably implicates systemwide changes in basic cellular activities such as transcriptional controls and signal cascades, and so on, as a cause. Recently, as one of these systemwide cellular changes associated with neurodegenerative diseas ...

  • Minireview  30 November 2016

    Viral Inhibition of PRR-Mediated Innate Immune Response: Learning from KSHV Evasion Strategies

    The innate immune system has evolved to detect and destroy invading pathogens before they can establish systemic infection. To successfully eradicate pathogens, including viruses, host innate immunity is activated through diverse pattern recognition receptors (PRRs) which detect conserved viral signatures and trigger the production of type I interferon (IFN) and pro-inflammatory cytokines to mediate viral clearance. Viral persistence requires that viruses co-opt cellular pathways and activiti ...

Mol. Cells 2016; 39(12): 841~914
Imaging Single-mRNA Localization and Translation in Live Neurons
Byung Hun Lee, Seong-Woo Bae, Jaeyoun Jay Shim, Sung Young Park, and Hye Yoon Park
Mol. Cells 2016; 39(12): 841-846  https://doi.org/10.14348/molcells.2016.0277 PDF PubMed PubReader Google Scholar Search
Cancer Metabolism: Fueling More than Just Growth
Namgyu Lee, and Dohoon Kim
Mol. Cells 2016; 39(12): 847-854  https://doi.org/10.14348/molcells.2016.0310 PDF PubMed PubReader Google Scholar Search
Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model
Chan-Mi Park, Hye-Min Kim, Dong Hyun Kim, Ho-Jin Han, Haneul Noh, Jae-Hyuk Jang, Soo-Hyun Park, Han-Jung Chae, Soo-Wan Chae, Eun Kyoung Ryu, Sangku Lee, Kangdong Liu, Haidan Liu, Jong-Seog Ahn, Young Ock Kim, Bo-Yeon Kim, and Nak-Kyun Soung
Mol. Cells 2016; 39(12): 855-861  https://doi.org/10.14348/molcells.2016.0111 PDF PubMed PubReader Google Scholar Search
Detecting Positive Selection of Korean Native Goat Populations Using Next-Generation Sequencing
Wonseok Lee, Sojin Ahn, Mengistie Taye, Samsun Sung, Hyun-Jeong Lee, Seoae Cho, and Heebal Kim
Mol. Cells 2016; 39(12): 862-868  https://doi.org/10.14348/molcells.2016.0219 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Overcomes Imatinib Resistance by Depleting BCR-ABL in Chronic Myeloid Leukemia
Xiaoyan Sun, Xueting Cai, Jie Yang, Jiao Chen, Caixia Guo, and Peng Cao
Mol. Cells 2016; 39(12): 869-876  https://doi.org/10.14348/molcells.2016.0023 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192
Rong-Yaun Shyu, Chun-Hua Wang, Chang-Chieh Wu, Mao-Liang Chen, Ming-Cheng Lee, Lu-Kai Wang, Shun-Yuan Jiang, and Fu-Ming Tsai
Mol. Cells 2016; 39(12): 877-887  https://doi.org/10.14348/molcells.2016.0161 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases
Varun Sasidharan Nair, Mi Hye Song, Myunggon Ko, and Kwon Ik Oh
Mol. Cells 2016; 39(12): 888-897  https://doi.org/10.14348/molcells.2016.0276 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Highly Expressed Integrin-α8 Induces Epithelial to Mesenchymal Transition-Like Features in Multiple Myeloma with Early Relapse
Jiyeon Ryu, Youngil Koh, Hyejoo Park, Dae Yoon Kim, Dong Chan Kim, Ja Min Byun, Hyun Jung Lee, and Sung-Soo Yoon
Mol. Cells 2016; 39(12): 898-908  https://doi.org/10.14348/molcells.2016.0210 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Baicalein Inhibits Epithelial to Mesenchymal Transition via Downregulation of Cyr61 and LOXL-2 in MDA-MB231 Breast Cancer Cells
Linh Thi Thao Nguyen, Yeon Woo Song, and Somi Kim Cho
Mol. Cells 2016; 39(12): 909-914  https://doi.org/10.14348/molcells.2016.0243 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
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Current Issue

31 December 2016
Volume 39,
Number 12,
pp. 841~914
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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