• Minireview  31 October 2018

    PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins

    Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without well-folded 3-D structures are still capable of performing important biological functions and furthermore are associated with fatal diseases such as cancers, neurodegenerative diseases and viral pa ...

  • Article  31 October 2018

    Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis

    Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs are synthetic ligands for PPARγ, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In thi ...

  • Article  31 October 2018

    Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic β Cells

    In pancreatic β cells, glucose stimulates the biosynthesis of insulin at transcriptional and post-transcriptional levels. The RNA-binding protein, polypyrimidine tract-binding protein 1 (PTBP1), also named hnRNP I, acts as a critical mediator of insulin biosynthesis through binding to the pyrimidine-rich region in the 3’-untranslated region (UTR) of insulin mRNA. However, the underlying mechanism that regulates its expression in β cells is unclear. Here, we report that glucose induces the ...

  • Minireview  31 October 2018

    Brain Somatic Mutations in Epileptic Disorders

    During the cortical development, cells in the brain acquire somatic mutations that can be implicated in various neurodevelopmental disorders. There is increasing evidence that brain somatic mutations lead to sporadic form of epileptic disorders with previously unknown etiology. In particular, malformation of cortical developments (MCD), ganglioglioma (GG) associated with intractable epilepsy and non-lesional focal epilepsy (NLFE) are known to be attributable to brain somatic mutations in mTOR ...


Mol. Cells 2018; 41(10): 881~932
Minireviews
Brain Somatic Mutations in Epileptic Disorders
Hyun Yong Koh, and Jeong Ho Lee
Mol. Cells 2018; 41(10): 881-888  https://doi.org/10.14348/molcells.2018.0247 PDF PubReader Google Scholar Search
PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins
Do-Hyoung Kim, and Kyou-Hoon Han
Mol. Cells 2018; 41(10): 889-899  https://doi.org/10.14348/molcells.2018.0192 PDF PubReader Google Scholar Search
Articles
Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis
Jee Hyung Sohn, Jong In Kim, Yong Geun Jeon, Jeu Park, and Jae Bum Kim
Mol. Cells 2018; 41(10): 900-908  https://doi.org/10.14348/molcells.2018.0294 PDF PubReader Google Scholar Search
Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic β Cells
Da Eun Jeong, Sungeun Heo, Ji Hye Han, Eun-young Lee, Rohit N. Kulkarni, and Wook Kim
Mol. Cells 2018; 41(10): 909-916  https://doi.org/10.14348/molcells.2018.0147 PDF PubReader Supplementary File(s) Google Scholar Search
Editing of Genomic TNFSF9 by CRISPR-Cas9 Can Be Followed by Re-Editing of Its Transcript
Hyeon-Woo Lee
Mol. Cells 2018; 41(10): 917-922  https://doi.org/10.14348/molcells.2018.0209 PDF PubReader Google Scholar Search
Arabidopsis ACC Oxidase 1 Coordinated by Multiple Signals Mediates Ethylene Biosynthesis and Is Involved in Root Development
Chan Ho Park, Jeehee Roh, Ji-Hyun Youn, Seung-Hyun Son, Ji Hye Park, Soon Young Kim, Tae-Wuk Kim, and Seong-Ki Kim
Mol. Cells 2018; 41(10): 923-932  https://doi.org/10.14348/molcells.2018.0092 PDF PubReader Supplementary File(s) Google Scholar Search
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Current Issue

31 October 2018
Volume 41,
Number 10,
pp. 881~932
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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