• Research Article  31 October 2019

    Oligomer Model of PB1 Domain of p62/SQSTM1 Based on Crystal Structure of Homo-Dimer and Calculation of Helical Characteristics

    Autophagy is an important process for protein recycling. Oligomerization of p62/SQSTM1 is an essential step in this process and is achieved in two steps. Phox and Bem1p (PB1) domains can oligomerize through both basic and acidic surfaces in each molecule. The ZZ-type zinc finger (ZZ) domain binds to target proteins and promotes higher-oligomerization of p62. This mechanism is an important step in routing target proteins to the autophagosome. Here, we determined the crystal structure of the PB ...

  • Research Article  31 October 2019

    Recovery of TRIM25-Mediated RIG-I Ubiquitination through Suppression of NS1 by RNA Aptamers

    Non-structural protein 1 (NS1) of influenza virus has been shown to inhibit the innate immune response by blocking the induction of interferon (IFN). In this study, we isolated two single-stranded RNA aptamers specific to NS1 with Kd values of 1.62 ± 0.30 nM and 1.97 ± 0.27 nM, respectively, using a systematic evolution of ligand by exponential enrichment (SELEX) procedure. The selected aptamers were able to inhibit the interaction of NS1 with tr ...

  • Research Article  31 October 2019

    The Role of Rice Vacuolar Invertase2 in Seed Size Control

    Sink strength optimizes sucrose import, which is fundamental to support developing seed grains and increase crop yields, including those of rice (Oryza sativa). In this regard, little is known about the function of vacuolar invertase (VIN) in controlling sink strength and thereby seed size. Here, in rice we analyzed mutants of two VINs, OsVIN1 and OsVIN2, to examine their role during seed development. In a phenotypic analysis of the T-DNA insertion mutants, only the OsVIN2 mu ...

  • Research Article  31 October 2019

    KMS99220 Exerts Anti-Inflammatory Effects, Activates the Nrf2 Signaling and Interferes with IKK, JNK and p38 MAPK via HO-1

    Neuroinflammation is an important contributor to the pathogenesis of neurodegenerative disorders including Parkinson’s disease (PD). We previously reported that our novel synthetic compound KMS99220 has a good pharmacokinetic profile, enters the brain, exerts neuroprotective effect, and inhibits NF-κB activation. To further assess the utility of KMS99220 as a potential therapeutic agent for PD, we tested whether KMS99220 exerts an anti-inflammatory effect in vivo ...


Mol. Cells 2019; 42(10): 687~738
Minireview
Transfer RNA-Derived Small Non-Coding RNA: Dual Regulator of Protein Synthesis
Hak Kyun Kim
Mol. Cells 2019; 42(10): 687-692  https://doi.org/10.14348/molcells.2019.0214 PDF PubMed PubMed Central PubReader Google Scholar Search
Research Articles
GIGANTEA Regulates the Timing Stabilization of CONSTANS by Altering the Interaction between FKF1 and ZEITLUPE
Dae Yeon Hwang, Sangkyu Park, Sungbeom Lee, Seung Sik Lee, Takato Imaizumi, and Young Hun Song
Mol. Cells 2019; 42(10): 693-701  https://doi.org/10.14348/molcells.2019.0199 PDF PubMed PubMed Central PubReader Google Scholar Search
KMS99220 Exerts Anti-Inflammatory Effects, Activates the Nrf2 Signaling and Interferes with IKK, JNK and p38 MAPK via HO-1
Ji Ae Lee, Dong Jin Kim, and Onyou Hwang
Mol. Cells 2019; 42(10): 702-710  https://doi.org/10.14348/molcells.2019.0129 PDF PubMed PubMed Central PubReader Google Scholar Search
The Role of Rice Vacuolar Invertase2 in Seed Size Control
Dae-Woo Lee, Sang-Kyu Lee, Md Mizanor Rahman, Yu-Jin Kim, Dabing Zhang, and Jong-Seong Jeon
Mol. Cells 2019; 42(10): 711-720  https://doi.org/10.14348/molcells.2019.0109 PDF PubMed PubMed Central PubReader Google Scholar Search
Recovery of TRIM25-Mediated RIG-I Ubiquitination through Suppression of NS1 by RNA Aptamers
Hye-Min Woo, Jin-Moo Lee, Chul-Joong Kim, Jong-Soo Lee, and Yong-Joo Jeong
Mol. Cells 2019; 42(10): 721-728  https://doi.org/10.14348/molcells.2019.0157 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Oligomer Model of PB1 Domain of p62/SQSTM1 Based on Crystal Structure of Homo-Dimer and Calculation of Helical Characteristics
Dahwan Lim, Hye Seon Lee, Bonsu Ku, Ho-Chul Shin, and Seung Jun Kim
Mol. Cells 2019; 42(10): 729-738  https://doi.org/10.14348/molcells.2019.0096 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
  • e-Submission
    e-Submission Old System (~2016)  e-Submission (2017~) New System
  • For review & Editor
    e-Submission Old System (~2016)  e-Submission (2017~) New System

Current Issue

31 October 2019
Volume 42,
Number 10,
pp. 687~738
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


  • Science Central
  • CrossMark

Indexed in

This journal is indexed in Science Citation Index, Scopus, Current Contents®/Life Science, Sci-search®, Research Alert®, Index Medicus, Chemical Abstract Service, and PubMed.

Manuscript Submission

To submit a manuscript, please visit the Molecules and Cells e-submission management system at http://www.ksmcb.or.kr/submission/Login.html, read the Instructions to Authors, and log into the Molecules and Cells e-submission system. For assistance with manuscript submission, please contact: admin@molcells.org.