• Article  31 January 2019

    USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization

    Ubiquitin-specific protease 44 (USP44) has been implicated in tumor progression and metastasis across various tumors. However, the function of USP44 in prostate cancers and regulatory mechanism of histone-modifying enzymes by USP44 in tumors is not well-understood. Here, we found that enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 methyltransferase, is regulated by USP44. We showed that EZH2 is a novel target of USP44 and that the protein stability of EZH2 is upregulated by USP44- ...

  • Minireview  31 January 2019

    Anti-Inflammatory Role of TAM Family of Receptor Tyrosine Kinases Via Modulating Macrophage Function

    Macrophage is an important innate immune cell that not only initiates inflammatory responses, but also functions in tissue repair and anti-inflammatory responses. Regulating macrophage activity is thus critical to maintain immune homeostasis. Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Growing evidence indicates that TAM family receptors play an important role in anti-inflammatory responses through modulating the function ...

  • Article  31 January 2019

    Crystal Structure of Histidine Triad Nucleotide-Binding Protein from the Pathogenic Fungus Candida albicans

    Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif. The HIT superfamily can be divided to five classes with functions in galactose metabolism, DNA repair, and tumor suppression. HINTs are highly conserved from archaea to humans and function as tumor suppressors, translation regulators, and neuropathy inhibitors. Although the structures of HINT proteins from various species have b ...

  • Minireview  31 December 2018

    BC200 RNA: An Emerging Therapeutic Target and Diagnostic Marker for Human Cancer

    One of the most interesting findings from genome-wide expression analysis is that a considerable amount of noncoding RNA (ncRNA) is present in the cell. Recent studies have identified diverse biological functions of ncRNAs, which are expressed in a much wider array of forms than proteins. Certain ncRNAs associated with diseases, in particular, have attracted research attention as novel therapeutic targets and diagnostic markers. BC200 RNA, a 200-nucleotide ncRNA originally identified as a neu ...


Mol. Cells 2019; 42(1): 1~96
Minireviews
Anti-Inflammatory Role of TAM Family of Receptor Tyrosine Kinases Via Modulating Macrophage Function
Chang-Hee Lee, and Taehoon Chun
Mol. Cells 2019; 42(1): 1-7  https://doi.org/10.14348/molcells.2018.0419 PDF PubReader Google Scholar Search
Mutation Hotspots in the β-Catenin Gene: Lessons from the Human Cancer Genome Databases
Sewoon Kim, and Sunjoo Jeong
Mol. Cells 2019; 42(1): 8-16  https://doi.org/10.14348/molcells.2018.0436 PDF PubReader Google Scholar Search
Articles
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization
Jae Min Park, Jae Eun Lee, Chan Mi Park, and Jung Hwa Kim
Mol. Cells 2019; 42(1): 17-27  https://doi.org/10.14348/molcells.2018.0329 PDF PubReader Supplementary File(s) Google Scholar Search
Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans
Jisoo Park, Woochan Choi, Abdul Rouf Dar, Rebecca A. Butcher, and Kyuhyung Kim
Mol. Cells 2019; 42(1): 28-35  https://doi.org/10.14348/molcells.2018.0380 PDF PubReader Supplementary File(s) Google Scholar Search
Effects of δ-Catenin on APP by Its Interaction with Presenilin-1
Weiye Dai, Taeyong Ryu, Hangun Kim, Yun Hye Jin, Young-Chang Cho, and Kwonseop Kim
Mol. Cells 2019; 42(1): 36-44  https://doi.org/10.14348/molcells.2018.0273 PDF PubReader Google Scholar Search
Experimental Applications of in situ Liver Perfusion Machinery for the Study of Liver Disease
Won-Mook Choi, Hyuk Soo Eun, Young-Sun Lee, Sun Jun Kim, Myung-Ho Kim, Jun-Hee Lee, Young-Ri Shim, Hee-Hoon Kim, Ye Eun Kim, Hyon-Seung Yi, and Won-Il Jeong
Mol. Cells 2019; 42(1): 45-55  https://doi.org/10.14348/molcells.2018.0330 PDF PubReader Supplementary File(s) Google Scholar Search
Crystal Structure of Histidine Triad Nucleotide-Binding Protein from the Pathogenic Fungus Candida albicans
Ahjin Jung, Ji-Sook Yun, Shinae Kim, Sang Ryong Kim, Minsang Shin, Dong Hyung Cho, Kwang Shik Choi, and Jeong Ho Chang
Mol. Cells 2019; 42(1): 56-66  https://doi.org/10.14348/molcells.2018.0377 PDF PubReader Supplementary File(s) Google Scholar Search
Hepatitis B Virus X Protein Stimulates Virus Replication Via DNA Methylation of the C-1619 in Covalently Closed Circular DNA
Hyehyeon Lee, Hyerin Jeong, Sun Young Lee, Soo Shin Kim, and Kyung Lib Jang
Mol. Cells 2019; 42(1): 67-78  https://doi.org/10.14348/molcells.2018.0255 PDF PubReader Google Scholar Search
Crystal Structure of LysB4, an Endolysin from Bacillus cereus-Targeting Bacteriophage B4
Seokho Hong, Bokyung Son, Sangryeol Ryu, and Nam-Chul Ha
Mol. Cells 2019; 42(1): 79-86  https://doi.org/10.14348/molcells.2018.0379 PDF PubReader Supplementary File(s) Google Scholar Search
Novel Discovery of LINE-1 in a Korean Individual by a Target Enrichment Method
Wonseok Shin, Seyoung Mun, Junse Kim, Wooseok Lee, Dong-Guk Park, Seungkyu Choi, Tae Yoon Lee, Seunghee Cha, and Kyudong Han
Mol. Cells 2019; 42(1): 87-95  https://doi.org/10.14348/molcells.2018.0351 PDF PubReader Supplementary File(s) Google Scholar Search
Erratum
Erratum to: Clearing and Labeling Techniques for Large-Scale Biological Tissues
Jinyoung Seo, Minjin Choe, and Sung-Yon Kim
Mol. Cells 2019; 42(1): 96-96  https://doi.org/10.14348/molcells.2019.1088 PDF PubReader Google Scholar Search
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Current Issue

31 January 2019
Volume 42,
Number 1,
pp. 1~96
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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