• Research Article  30 November 2019

    Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells

    Periodontitis is characterized by the loss of periodontal tissues, especially alveolar bone. Common therapies cannot satisfactorily recover lost alveolar bone. Periodontal ligament stem cells (PDLSCs) possess the capacity of self-renewal and multilineage differentiation and are likely to recover lost alveolar bone. In addition, periodontitis is accompanied by hypoxia, and hypoxia-inducible factor-1α (HIF-1α) is a master transcription factor in the response to hypoxia. Thus, we aimed to asce ...

  • Research Article  30 November 2019

    Colorectal Cancer Therapy Using a Pediococcus pentosaceus SL4 Drug Delivery System Secreting Lactic Acid Bacteria-Derived Protein p8

    Despite decades of research into colorectal cancer (CRC), there is an ongoing need for treatments that are more effective and safer than those currently available. Lactic acid bacteria (LAB) show beneficial effects in the context of several diseases, including CRC, and are generally regarded as safe. Here, we isolated a Lactobacillus rhamnosus (LR)-derived therapeutic protein, p8, which suppressed CRC proliferation. We found that p8 translocated specifically to the cytosol of ...

  • Minireview  30 November 2019

    Cellular and Molecular Links between Autoimmunity and Lipid Metabolism

    The incidence of atherosclerosis is higher among patients with several autoimmune diseases such as psoriasis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It is well documented that innate immune cells including macrophages and dendritic cells sense lipid species such as saturated fatty acids and oxidized low-density lipoprotein and produce pro-inflammatory cytokines and chemokines. However, whether a hyperlipidemic environment also impacts autoimmune T cell responses has ...

  • Minireview  30 November 2019

    ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer’s Disease

    Significant knowledge about the pathophysiology of Alzheimer’s disease (AD) has been gained in the last century; however, the understanding of its causes of onset remains limited. Late-onset AD is observed in about 95% of patients, and APOE4-encoding apolipoprotein E4 (ApoE4) is strongly associated with these cases. As an apolipoprotein, the function of ApoE in brain cholesterol transport has been extensively studied and widely appreciated. Development of new technologies s ...


Mol. Cells 2019; 42(11): 739~819
Minireviews
ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer’s Disease
Woojin Jeong, Hyein Lee, Sukhee Cho, and Jinsoo Seo
Mol. Cells 2019; 42(11): 739-746  https://doi.org/10.14348/molcells.2019.0200 PDF PubMed PubReader Google Scholar Search
Cellular and Molecular Links between Autoimmunity and Lipid Metabolism
Heeju Ryu, Jiyeon Kim, Daehong Kim, Jeong-Eun Lee, and Yeonseok Chung
Mol. Cells 2019; 42(11): 747-754  https://doi.org/10.14348/molcells.2019.0196 PDF PubMed PubReader Google Scholar Search
Research Articles
Colorectal Cancer Therapy Using a Pediococcus pentosaceus SL4 Drug Delivery System Secreting Lactic Acid Bacteria-Derived Protein p8
Byung Chull An, Yongku Ryu, Yeo-Sang Yoon, Oksik Choi, Ho Jin Park, Tai Yeub Kim, Song-In Kim, Bong-Kyu Kim, and Myung Jun Chung
Mol. Cells 2019; 42(11): 755-762  https://doi.org/10.14348/molcells.2019.0064 PDF PubMed PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
Qian Xu, Zhihua Liu, Ling Guo, Rui Liu, Rulei Li, Xiang Chu, Jiajia Yang, Jia Luo, Faming Chen, and Manjing Deng
Mol. Cells 2019; 42(11): 763-772  https://doi.org/10.14348/molcells.2019.0023 PDF PubMed PubReader Google Scholar Search
Dephosphorylation of p53 Ser 392 Enhances Trimethylation of Histone H3 Lys 9 via SUV39h1 Stabilization in CK2 Downregulation-Mediated Senescence
Jeong-Woo Park and Young-Seuk Bae
Mol. Cells 2019; 42(11): 773-782  https://doi.org/10.14348/molcells.2019.0018 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Development of a Reporter System Monitoring Regulated Intramembrane Proteolysis of the Transmembrane bZIP Transcription Factor ATF6α
Jin-Ik Kim, Randal J. Kaufman, Sung Hoon Back, and Ja-Young Moon
Mol. Cells 2019; 42(11): 783-793  https://doi.org/10.14348/molcells.2019.0104 PDF PubMed PubReader Google Scholar Search
Involvement of lncRNA-HOTTIP in the Repair of Ultraviolet Light-Induced DNA Damage in Spermatogenic Cells
Meng Liang and Ke Hu
Mol. Cells 2019; 42(11): 794-803  https://doi.org/10.14348/molcells.2019.0121 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Overexpression and Selective Anticancer Efficacy of ENO3 in STK11 Mutant Lung Cancers
Choa Park, Yejin Lee, Soyeon Je, Shengzhi Chang, Nayoung Kim, Euna Jeong, and Sukjoon Yoon
Mol. Cells 2019; 42(11): 804-809  https://doi.org/10.14348/molcells.2019.0099 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
ST5 Positively Regulates Osteoclastogenesis via Src/Syk/calcium Signaling Pathways
Min Kyung Kim, Bongjun Kim, Jun-Oh Kwon, Min-Kyoung Song, Suhan Jung, Zang Hee Lee, and Hong-Hee Kim
Mol. Cells 2019; 42(11): 810-819  https://doi.org/10.14348/molcells.2019.0189 PDF PubMed PubReader Google Scholar Search
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Current Issue

30 November 2019
Volume 42,
Number 11,
pp. 739~819
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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