Mol. Cells 2013; 35(6): 550~556  DOI: 10.1007/s10059-013-0088-8
Angiopoietin-1 Elicits Pro-Inflammatory Responses in Monocytes and Differentiating Macrophages
Seung Hyeok Seok, Jong-Ik Heo, Ji-Hye Hwang, Yi-Rang Na, Jang-Hyuk Yun, Eun Hui Lee, Jong-Wan Park, and Chung-Hyun Cho
Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 110-799, Korea, 1Department of Microbiology and Immunology and Institute of Endemic Disease, 2Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Received March 19, 2013; Revised April 20, 2013; Accepted April 22, 2013.; Published online May 16, 2013.
© The Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
The angiopoietin/Tie2 system is an important regulator of angiogenesis and inflammation. In addition to its functions in endothelial cells, Tie2 expression on non-endothelial cells allows for angiopoietin ligands to stimulate the cells. Although Ang1 is a strong Tie2 receptor agonist, little is known regarding the effect of Ang1 on non-endothelial cells, such as monocytes and macrophages. In this study, we found that Ang1 functionally binds to and stimulates monocytes via p38 and Erk1/2 phosphorylation. Ang1-mediated monocyte stimulation is associated with pro-inflammatory cytokine TNF-alpha expression. We also determined that Ang1 switched macrophage differentiation toward a pro-inflammatory phenotype, even in the presence of an anti-inflammatory mediator. These findings suggest that Ang1 plays a role in stimulating pro-inflammatory responses and could provide a new strategy by which to manage inflammatory responses.
Keywords: angiopoietin, inflammation, macrophage, monocyte, Tie2
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