Mol. Cells 1991; 1(4): 381~384  
Protein-Protein Communications within the Transcription Apparatus
Akira Ishihama
Department of Molecular Genetics, National Institute of Genetics. and School of Life Science, Graduate University of Advanced Studies, Mishima, Shizuoka 411, Japan
; Published online December 31, 1991.
© The Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
Gene transcription is regulated by controlling either the promoter activity of the DNA template or the promoter selectivity of RNA polymerase. A number of regulatory proteins are involved in these processes, which bind to either the transcription signals on DNA or the RNA polymerase. Several lines of evidence indicate that many DNA-binding transcription factors also exert their regulatory functions through interaction with the RNA polymerase after they bind to the DNA. The molecular communication between RNA polymerase and transcription factors is therefore a key element in the determination of promoter selection pattern, irrespective of apparent differences in the mechanism of promoter-RNA polymerase-transcription factor ternary complex formation. The variation in transcription rate between genes within a single cell is thus determined by the intracellular levels of individual transcription factors.

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COVER PICTURE Non-mitochondrial localization of the N-terminal-deleted mutant form of ACSL1 in Cos7 cells. Green, ACSL1 mutant; Red, mitotracker; Blue, DAPI (Nan et al., pp. 637-646).

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