Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice
Young Lee1, Na-Eun Han1, Wonju Kim1, Jae Gon Kim1, In Bum Lee1, Su Jeong Choi7, Heejung Chun2, Misun Seo3,4, C. Justin Lee2, Hae-Young Koh3,4, Joung-Hun Kim5, Ja-Hyun Baik1, Mark F. Bear6,
Se-Young Choi7, and Bong-June Yoon1,*
1Department of Life Sciences, Korea University, Seoul 02841, Korea, 2Cognitive Glioscience Group, Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 34126, Korea, 3Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea, 4Department of Neuroscience, University of Science and Technology (UST), Daejeon 34113, Korea, 5Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea, 6The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, 7Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry, Seoul 03080, Korea
Received November 19, 2019; Revised December 13, 2019; Accepted December 17, 2019.; Published online January 14, 2020.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) (‘bridging collaterals’) was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.
Keywords: basal ganglia, bridging collaterals, globus pallidus, stress


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31 March 2020 Volume 43,
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