Mol. Cells 2018; 41(0): 0
Makorin 1 Regulates Developmental Timing in Drosophila
Hong Thuan Tran1,2, Eunjoo Cho1,2, Seongsu Jeong1,2, Eui Beom Jeong1,2, Hae Sang Lee3, Seon Yong Jeong4, Jin Soon Hwang3, and Eun Young Kim1,2,*
1Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Kyunggi-do 16499, Korea, 2Department of Brain Science, Ajou University Medical Center, 3Department of Pediatrics, Ajou University Medical Center, 4Department of Medical Genetics, Ajou University Medical Center, Kyunggi-do 16499, Korea

Received September 3, 2018; Revised September 15, 2018; Accepted September 25, 2018.; Published online November 6, 2018.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

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Drosophila ortholog of mammalian makorin genes, in the regulation of developmental timing. Loss of MKRN1 in mkrn1exS prolonged the 3rd instar stage and delayed the onset of pupariation, resulting in bigger size pupae. MKRN1 was expressed in the prothoracic gland, where the steroid hormone ecdysone is produced. Furthermore, mkrn1exS larvae exhibited reduced mRNA levels of phantom, which encodes ecdysone-synthesizing enzyme and E74, which is a downstream target of ecdysone. Collectively, these results indicate that MKRN1 fine-tunes developmental timing and sexual maturation by affecting ecdysone synthesis in Drosophila. Moreover, our study supports the notion that malfunction of makorin gene family member, mkrn3 dysregulates the timing of puberty in mammals.
Drosophila, growth, makorin1, makorin3, sexual maturation

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30 November 2018 Volume 41,
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