Mol. Cells 2020; 43(9): 774~783
WNT Signaling in Lung Repair and Regeneration
Ahmed A. Raslan 1,2 and Jeong Kyo Yoon 1,2,*
1Soonchunhyang Institute of Medi-bio Science and 2Department of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, Korea
Received March 5, 2020; Revised July 6, 2020; Accepted July 23, 2020.; Published online August 14, 2020.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

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The lung has a vital function in gas exchange between the blood and the external atmosphere. It also has a critical role in the immune defense against external pathogens and environmental factors. While the lung is classified as a relatively quiescent organ with little homeostatic turnover, it shows robust regenerative capacity in response to injury, mediated by the resident stem/progenitor cells. During regeneration, regionally distinct epithelial cell populations with specific functions are generated from several different types of stem/progenitor cells localized within four histologically distinguished regions: trachea, bronchi, bronchioles, and alveoli. WNT signaling is one of the key signaling pathways involved in regulating many types of stem/progenitor cells in various organs. In addition to its developmental role in the embryonic and fetal lung, WNT signaling is critical for lung homeostasis and regeneration. In this minireview, we summarize and discuss recent advances in the understanding of the role of WNT signaling in lung regeneration with an emphasis on stem/progenitor cells.
Keywords: β-catenin, lung homeostasis, lung regeneration, lung stem/progenitor cells, WNT signaling

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30 September 2020 Volume 43,
Number 9, pp. 763~840

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