Mol. Cells 2019; 42(): 189  https://doi.org/10.14348/molcells.2019.2431
Microbial Colonization at Early Life Promotes the Development of Diet-Induced CD8αβ Intraepithelial T Cells
Jisun Jung1,2, Charles D. Surh1,2,3, and You Jeong Lee1,2,*
1Academy of Immunology and Microbiology, Institute for Basic Science (IBS), Pohang 37673, Korea, 2Division of Integrative Biosciences & Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea, 3Division of Developmental Immunology, La Jolla Institute for Allergy & Immunology, CA 92037, USA
Received November 21, 2018; Revised December 16, 2018; Accepted December 20, 2018.; Published online March 28, 2019.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit (http://creativecommons.org/licenses/by-nc-sa/3.0/).
ABSTRACT
Intraepithelial lymphocytes (IELs) develop through the continuous interaction with intestinal antigens such as commensal microbiome and diet. However, their respective roles and mutual interactions in the development of IELs are largely unknown. Here, we showed that dietary antigens regulate the development of the majority of CD8αβ IELs in the small intestine and the absence of commensal microbiota particularly during the weaning period, delay the development of IELs. When we tested specific dietary components, such as wheat or combined corn, soybean and yeast, they were dependent on commensal bacteria for the timely development of diet-induced CD8αβ IELs. In addition, supplementation of intestinal antigens later in life was inefficient for the full induction of CD8αβ IELs. Overall, our findings suggest that early exposure to commensal bacteria is important for the proper development of dietary antigen-dependent immune repertoire in the gut.
Keywords: antigen free, dietary antigen, germ free, intraepithelial T cells, microbiota


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