Role of RUNX Family Members in G1 Restriction Point Regulation
Jung-Won Lee* and Suk-Chul Bae*
Department of Biochemistry, College of Medicine, Chungbuk National University, Cheongju 28644, Korea
Received December 20, 2019; Accepted December 20, 2019.; Published online January 28, 2020.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
When cells are stimulated by growth factors, they make a critical choice in early G1, phase: proceed forward to S phase, remain in G1, or revert to G0, phase. Once the critical decision is made, cells execute a fixed program independently of extracellular signals. The specific stage at which the critical decision is made is called the restriction point or R-point. The existence of the R-point raises a major question: what is the nature of the molecular machinery that decides whether or not a cell in G1, will continue to advance through the cell cycle or exit from the cell cycle? The R-point program is perturbed in nearly all cancer cells. Therefore, exploring the nature of the R-point decision-making machinery will provide insight into how cells consult extracellular signals and intracellular status to make an appropriate R-point decision, as well into the development of cancers. Recent studies have shown that expression of a number of immediate early genes is associated with the R-point decision, and that the decisionmaking program constitutes an oncogene surveillance mechanism. In this review, we briefly summarize recent findings regarding the mechanisms underlying the contextdependent R-point decision.
Keywords: BRD, PcG complex, restriction point, RUNX, TrxG complex


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31 January 2020 Volume 43,
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