The Roles of RUNX Family Proteins in Development of Immune Cells
Wooseok Seo1,2,* and Ichiro Taniuchi2
1 Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan, 2Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan
Received November 26, 2019; Accepted December 12, 2019.; Published online January 10, 2020.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
The Runt-related transcription factors (RUNX) transcription factors have been known for their critical roles in numerous developmental processes and diseases such as autoimmune disorders and cancer. Especially, RUNX proteins are best known for their roles in hematopoiesis, particularly during the development of T cells. As scientists discover more types of new immune cells, the functional diversity of RUNX proteins also has been increased over time. Furthermore, recent research has revealed complicated transcriptional networks involving RUNX proteins by the current technical advances. Databases established by next generation sequencing data analysis has identified ever increasing numbers of potential targets for RUNX proteins and other transcription factors. Here, we summarize diverse functions of RUNX proteins mainly on lymphoid lineage cells by incorporating recent discoveries.
Keywords: development, immune cells, Runx family, transcription factors


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31 December 2019 Volume 42,
Number 12, pp. 821~918

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