Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila
Yoon Seok Suh1,2, Eunbyul Yeom1, Jong-Woo Nam3, Kyung-Jin Min3, Jeongsoo Lee1,2, and Kweon Yu1,2,4,*
1Metabolism and Neurophysiology Research Group, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Korea, 2Convergence Research Center of Dementia, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea, 3Department of Biological Sciences, Inha University, Incheon 22212, Korea, 4Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34113, Korea
Received November 15, 2019; Revised December 18, 2019; Accepted December 18, 2019.; Published online January 14, 2020.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
Methionyl-tRNA synthetase (MRS) is essential for translation. MRS mutants reduce global translation, which usually increases lifespan in various genetic models. However, we found that MRS inhibited Drosophila reduced lifespan despite of the reduced protein synthesis. Microarray analysis with MRS inhibited Drosophila revealed significant changes in inflammatory and immune response genes. Especially, the expression of anti-microbial peptides (AMPs) genes was reduced. When we measured the expression levels of AMP genes during aging, those were getting increased in the control flies but reduced in MRS inhibition flies agedependently. Interestingly, in the germ-free condition, the maximum lifespan was increased in MRS inhibition flies compared with that of the conventional condition. These findings suggest that the lifespan of MRS inhibition flies is reduced due to the down-regulated AMPs expression in Drosophila
Keywords: anti-microbial peptides, Drosophila, lifespan, methionyl-tRNA synthetase
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31 January 2020 Volume 43,
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