The Role of Lozenge in Drosophila Hematopoiesis
Ferdinand Koranteng1,4, Nuri Cha1,4, Mingyu Shin1,4, and Jiwon Shim1,2,3,*
1Department of Life Science, Hanyang University, Seoul 04763, Korea, 2Research Institute for Natural Science, Hanyang University, Seoul 04763, Korea, 3Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Korea, 4These authors contributed equally to this work.
Received October 30, 2019; Accepted December 4, 2019.; Published online January 29, 2020.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

Drosophila hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of Drosophila genetics. A Runt domain protein, lozenge, is one of the first players recognized and closely studied in the hematopoietic lineage specification. Here, we explore the role of lozenge in determination of prohemocytes into a special class of hemocyte, namely the crystal cell, and discuss molecules and signals controlling the lozenge function and its implication in immunity and stress response. Given the highly conserved nature of Runt domain in both invertebrates and vertebrates, studies in Drosophila will enlighten our perspectives on Runxmediated development and pathologies.
Keywords: crystal cells, Drosophila melanogaster, hematopoiesis, lozenge, lymph gland, melanization, prophenoloxidase, RUNX

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31 January 2020 Volume 43,
Number 1, pp. 1~95

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