Synergistic Ensemble of Optogenetic Actuators and Dynamic Indicators in Cell Biology
Jihoon Kim1, and Won Do Heo1,2,3,*
1Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea,
2Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 341141, Korea, 3KAIST Institute for the BioCentury,
Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
Received July 10, 2018; Accepted August 7, 2018.; Published online August 29, 2018.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

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Discovery of the naturally evolved fluorescent proteins and their genetically engineered biosensors have enormously contributed to current bio-imaging techniques. These reporters to trace dynamic changes of intracellular protein activities have continuously transformed according to the various demands in biological studies. Along with that, light-inducible optogenetic technologies have offered scientists to perturb, control and analyze the function of intracellular machineries in spatiotemporal manner. In this review, we present an overview of the molecular strategies that have been exploited for producing genetically encoded protein reporters and various optogenetic modules. Finally, in particular, we discuss the current efforts for combined use of these reporters and optogenetic modules as a powerful tactic for the control and imaging of signaling events in cells and tissues.
Keywords: biosensor, optogenetics

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31 August 2018 Volume 41,
Number 8, pp. 705~807

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