Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers
Dongseok Park1,2, Sungwon Bae1,2, Taek Han Yoon1,2, and Jaewon Ko1,*
1Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988,
Korea, 2These authors contributed equally to this work.
Received February 25, 2018; Revised March 30, 2018; Accepted April 2, 2018.; Published online April 18, 2018.
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Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present minireview, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum.
Keywords: brain disorder, neural circuit, specificity, synapse, synaptic adhesion

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30 April 2018 Volume 41,
Number 4, pp. 257~372

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