Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape
Jung-Ae Kim1,2,*
1Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141,
Korea, 2Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon 34113,
Received February 25, 2018; Revised March 13, 2018; Accepted March 28, 2018.; Published online April 11, 2018.
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Cells cope with diverse intrinsic and extrinsic stimuli in order to make adaptations for survival. The epigenetic landscape plays a crucial role in cellular adaptation, as it integrates the information generated from stimuli. Signaling pathways induced by stimuli communicate with chromatin to change the epigenetic landscape through regulation of epigenetic modifiers. Metabolic dynamics altered by these stimuli also affect the activity of epigenetic modifiers. Here, I review the current understanding of epigenetic regulation via signaling and metabolic pathways. In addition, I will discuss possible ways to achieve specificity of epigenetic modifications through the cooperation of stimuli-induced signal transduction and metabolic reprogramming.
Keywords: cancer, differentiation, epigenetics, metabolism, signaling

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31 March 2018 Volume 41,
Number 3, pp. 161~255

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