Mol. Cells 2017; 40(11):   https://doi.org/10.14348/molcells.2017.0137
Endophilin A2: A Potential Link to Adiposity and Beyond
Assim A. Alfadda1,2,*, Reem M. Sallam1,3, Rukhsana Gul1, Injae Hwang4, and Sojeong Ka5
1Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia, 2Department of Medicine,
College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia, 3Clinical Chemistry Unit, Pathology Department, College
of Medicine, King Saud University, Riyadh 11461, Saudi Arabia, 4Department of Biological Sciences, Institute of Molecular
Biology and Genetics, Seoul National University, Seoul 08826, Korea, 5Department of Agricultural Biotechnology, College of
Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
*Correspondence: aalfadda@ksu.edu.sa
Received July 19, 2017; Revised September 7, 2017; Accepted September 20, 2017.; Published online November 6, 2017.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit (http://creativecommons.org/licenses/by-nc-sa/3.0/).
ABSTRACT
Adipose tissue plays a central role in regulating dynamic crosstalk between tissues and organs. A detailed description of molecules that are differentially expressed upon changes in adipose tissue mass is expected to increase our understanding of the molecular mechanisms that underlie obesity and related metabolic co-morbidities. Our previous studies suggest a possible link between endophilins (SH3Grb2 proteins) and changes in body weight. To explore this further, we sought to assess the distribution of endophilin A2 (EA2) in human adipose tissue and experimental animals. Human paired adipose tissue samples (subcutaneous and visceral) were collected from subjects undergoing elective abdominal surgery and abdominal liposuction. We observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with TNF-α in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro. In conclusion, this study provides a description of EA2 distribution and emphasizes a need to study the roles of this protein during the progression of obesity.
Keywords: adipose tissue, endophilin A2, obesity, SH3GL1


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