Mol. Cells 2017; 40(6): 434~439  https://doi.org/10.14348/molcells.2017.0053
Gestational Diabetes Affects the Growth and Functions of Perivascular Stem Cells
Borim An1,8, Eunbi Kim1,8, Haengseok Song2, Kwon-Soo Ha3, Eun-Taek Han4, Won Sun Park5, Tae Gyu Ahn6, Se-Ran Yang7, Sunghun Na6,*, and Seok-Ho Hong1,*
1Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon 24341, Korea, 2Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13496, Korea, 3Department of Molecular and Cellular Biochemistry, 4Department of Medical Environmental Biology and Tropical Medicine, 5Department of Physiology, 6Department of Obstetrics and Gynecology, 7Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kangwon National University, Chuncheon 24341, Korea, 8These authors contributed equally to this work.
*Correspondence: shhong@kangwon.ac.kr (SHH); lahun@kangwon.ac.kr (SN)
Received March 31, 2017; Revised May 1, 2017; Accepted May 11, 2017.; Published online June 13, 2017.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit (http://creativecommons.org/licenses/by-nc-sa/3.0/).
ABSTRACT
Gestational diabetes mellitus (GDM), one of the common metabolic disorders of pregnancy, leads to functional alterations in various cells including stem cells as well as some abnormalities in fetal development. Perivascular stem cells (PVCs) have gained more attention in recent years, for the treatment of various diseases. However, the effect of GDM on PVC function has not been investigated. In our study, we isolated PVCs from umbilical cord of normal pregnant women and GDM patients and compared their phenotypes and function. There is no significant difference in phenotypic expression, response to bFGF exposure and adipogenic differentiation capacity between normal PVCs and GDM-PVCs. However, when compared with normal PVCs, early passage GDMPVCs displayed decreased initial rates of cell yield and proliferation as well as a reduced ability to promote wound closure. These results suggest that maternal metabolic dysregulation during gestation can alter the function of endogenous multipotent stem cells, which may impact their therapeutic effectiveness.
Keywords: differentiation, gestational diabetes mellitus, perivascular
stem cells, proliferation


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