Involvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods
Haein Kim1, Yong Taek Jeong2, Min Sung Choi1, Jaekyun Choi1, Seok Jun Moon2,*, and Jae Young Kwon1,*
1Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea, 2Department of Oral Biology, BK21 PLUS
Project, Yonsei University College of Dentistry, Seoul 03722, Korea
*Correspondence: (JYK); (SJM)
Received February 23, 2017; Revised April 3, 2017; Accepted April 18, 2017.; Published online May 2, 2017.
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Regulation of feeding is essential for animal survival. The pharyngeal sense organs can act as a second checkpoint of food quality, due to their position between external taste organs such as the labellum which initially assess food quality, and the digestive tract. Growing evidence provides support that the pharyngeal sensory neurons regulate feeding, but much is still unknown. We found that a pair of gustatory receptor neurons in the LSO, a Drosophila adult pharyngeal organ which expresses four gustatory receptors, is involved in feeding inhibition in response to high concentrations of sodium ions. RNAi experiments and mutant analysis showed that the gustatory receptor Gr2a is necessary for this process. This feeding preference determined by whether a food source is perceived as appetizing or not is influenced by nutritional conditions, such that when the animal is hungry, the need for energy dominates over how appealing the food source is. Our results provide experimental evidence that factors involved in feeding function in a context-dependent manner.
Keywords: Drosophila melanogaster, feeding, gustatory receptor, pharyngeal sense organ

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30 April 2017 Volume 40,
Number 4, pp. 243~314

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