Signaling Pathways Controlling Microglia Chemotaxis
Yang Fan, Lirui Xie, and Chang Y. Chung*
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P.R. China
Received January 24, 2017; Revised March 5, 2017; Accepted March 7, 2017.; Published online March 17, 2017.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

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Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain’s innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.
Keywords: activation, chemotaxis, cell migration, microglia, P2Y12 receptor

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28 February 2017 Volume 40,
Number 2, pp. 83~161

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