Mol. Cells 2011; 31(5): 423~429  DOI: 10.1007/s10059-011-0256-7
Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence
Jong Seok Yun, Jung Woon Pahk, Jong Seok Lee, Won Cheol Shin, Shin Young Lee, and Eock Kee Hong*
Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea
*Correspondence: ekhong@kangwon.ac.kr
Received October 13, 2011; Accepted January 31, 2011.; Published online February 22, 2011.
© The Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senes-cence.
Keywords: antioxidant, apoptosis, Inonotus obliquus, reactive oxygen species (ROS), stress-induced premature senescence


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