Molecules and Cells

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Fig. 1.

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Fig. 1. Advantages of using a combinatorial approach, employing both C. elegans and mammalian systems, in aging research. C. elegans has various advantages as a model organism in aging research, e.g., genetic tractability for random mutagenesis and RNAi screen, a large brood size, and a relatively short wild-type lifespan of 2-3 weeks. Mammalian systems, such as mouse models, compensate the limitations of C. elegans because of their physiological similarity to humans, suitability as age-associated disease models (such as being models of Alzheimer’s disease and sarcopenia), and amenability to organ-level approaches. By exploiting the advantages of these two complementary model systems, researchers can efficiently elucidate evolutionarily conserved aging mechanisms.
Mol. Cells 2021;44:425~432
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