Molecules and Cells

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Fig. 1.

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Fig. 1. Development and function of ILCs. ILC differentiation proceeds in a stepwise fashion from hematopoietic stem cells (HSCs) to lymphoid lineage restricted precursors. The development of ILCs from CLPs requires ID2-mediated suppression of alternative lymphoid cell fates that generate B and T cells. CLPs further commit to the ILC/NK lineage via multiā€potent ILCp. Individual subsets depend on the expression of specific transcription factors that determine their terminal differentiation and function. CLP, common lymphoid progenitor; EILP, early innate lymphoid progenitor; CHILP, common helper ILC precursor; NKp, NK cell precursor; ILCp, ILC precursor; LTip, LTi cell precursor.
Mol. Cells 2021;44:301~309
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