Molecules and Cells

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Fig. 1.

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Fig. 1. Gut microbiota immune modulation and Immune checkpoint inhibitors. Gut microbiota activates the T cell priming process of dendritic cells. In this process, anti-CTLA 4 antibody has synergy with the Immune stimulatory microbiota (such as Bacteroides species). As a result, it promotes the formation of functional effector T cells. In addition, intestinal microbes affect CD4 T cell recruitment and activation. Enrichment of certain intestinal microbes, such as Akkermansia muciniphila or Bifidobacterium species, contributes to enhancement and expansion of functional CD8 T cells, IFN-γ production, and increased granzyme and perforin secretion. These points contribute to enhancing the effect of the PD-1/PD-L1 blockade, thus contributing to enhancing the antitumor immunity.
Mol. Cells 2021;44:356~362
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