Molecules and Cells

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Fig. 7.

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Fig. 7. HYOU1 expression is downregulated by the inhibition of the PI3K/AKT/mTOR pathway. (A) Expression levels of HYOU1 in NSCLC cells (NCI-H460 and H1299) treated with 0.1 μM or 1 μM of an mTOR inhibitor (Torin2 or WYE-125132) or a PI3K inhibitor (GDC0032 or PKI-402). (B) Expression levels of HYOU1 and mTOR in NSCLC cells (NCI-H460 and H1299) transfected with nonspecific siRNA (siCont), HYOU1 siRNA (siHYOU1), or mTOR siRNA (simTOR). The data shown are the mean ± SD from three independent experiments; *P < 0.05 compared to the control group.
Mol. Cells 2021;44:50~62
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