Molecules and Cells

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Fig. 2.

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Fig. 2. HYOU1 expression is increased by factors secreted in response to crosstalk between ECs and lung cancer cells. (A) A gene expression heat map representing fold changes greater than 1.5 in samples from lung cancer spheroids grown in CM from cultured HUVECs, cultured NCI-H460 cells, or lung cancer cells co-cultured with HUVECs. (B and C) Categorization of biological pathways (B) and biological processes (C) identified by microarray analysis as markedly altered in lung cancer spheroids grown in CM from cultured HUVECs, cultured NCI-H460 cells, or lung cancer cells co-cultured with HUVECs. (D) Expression levels of CARS, HYOU1, MARS, and pAKT (Ser437) in lung cancer spheroids grown in CM from NCI-H460 cells cultured alone or co-cultured with HUVECs, as assessed by western blot analysis.
Mol. Cells 2021;44:50~62 https://doi.org/10.14348/molcells.2020.0212
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