Molecules and Cells

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 0219-1032   pISSN 1016-8478

Fig. 3.

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Fig. 3. KR-CreERT1 mice develop lymphomas and skin cancers, as well as lung ADs/ADCs. (A) Gross and microscopic images of a skin cancer that developed in a KR-CreERT1 mouse. (B) Gross and microscopic images of the spleen and thymus of WT and KR-CreERT1 mice. Histological analysis revealed that the cortex–medulla boundary in the enlarged thymuses was obscure and filled with undifferentiated T-cells, indicating thymic lymphoma. (C) HE-stained gross images and magnified microscopic images of thymus and lung of KRT-CreERT2 mice (6 months after birth). Lung-invading tumor cells were morphologically identical to thymic lymphoma cells, indicating that the lung-invading tumors originated from a thymic lymphoma. (D) Targeting of the K-Ras* and Runx3flox alleles by leaky activation of CreERT1 in tumors was verified by genomic PCR. L, lung ADC; Th, thymus; Sp, spleen; Sk, skin cancer. Targeting of the K-Ras* and Runx3flox alleles by leaky activation of CreERT2 in tumors was verified by genomic PCR. M, DNA size marker; L, lung ADC; Th, thymus; LT, lung infiltrated thymic lymphoma.
Mol. Cells 2020;43:889~897 https://doi.org/10.14348/molcells.2020.0182
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