Molecules and Cells

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Fig. 2.

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Fig. 2. The combination of K-Ras activation and Runx3 inactivation is the minimum molecular requirement for induction of lung tumor formation. (A) Microscopic images of lungs of T-CreERT2 and KT-CreERT2 mouse (6 months after birth) stained with anti-Tomato antibody. Tomato-positive cells (red) are indicated by arrows. (B) HE staining of the lungs of KPT-CreERT2 and KRT-CreERT2 mice (6 months after birth). (C and D) Microscopic images of lungs of KPT-CreERT2 mice and KRT-CreERT2 mice (6 months after birth) stained with HE or anti-Tomato antibody. Magnified images of the boxed regions are shown (lower panels). Small clusters of Tomato-positive cells were detected in KPT-CreERT2 mice, but did not develop into cancers. By contrast, Tomato-positive cells in KRT-CreERT2 mice developed into cancers.
Mol. Cells 2020;43:889~897 https://doi.org/10.14348/molcells.2020.0182
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