Molecules and Cells

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Fig. 2.

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Fig. 2. HOXA11-AS upregulates c-Met by absorbing miR-454-3p. (A) The prediction website StarBase revealed the binding site between HOXA11-AS and miR-454-3p. (B) The prediction of TargetScan showed the binding site between miR-454-3p and c-Met. (C and D) Dual luciferase reporter gene assay verified the relationship between HOXA11-AS and miR-454-3p (C) and between miR-454-3p and c-Met (D); *P < 0.05 vs miR-NC group. (E) RIP experiment with an anti-Ago2 antibody, with IgG as a negative control or input from HNE1 and C666-1 cells using qRT-PCR as a positive control; *P < 0.05 vs anti-IgG group. (F) RNA pull-down assay were used to verify the target site between HOXA11-AS and miR-454-3p and between miR-454-3p and c-Met; *P < 0.05 vs beads group.
Mol. Cells 2020;43:856~869 https://doi.org/10.14348/molcells.2020.0133
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