Molecules and Cells

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Fig. 9.

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Fig. 9. Schematic diagram of how the STAT3/WDR1 signaling axis promotes intimal thickening. When the artery is exposed to stimuli (e.g., external force, hypo­xia, or inflammation), cytokines that activate the JAK2/STAT3 pathway are released. Activated STAT3 translocates to the nucleus, where it directly increases the trans­criptional activity and subse­quent expression of WDR1. Ele­vated levels of WDR1 enhance the proliferation and migration of smooth muscle cells. Smooth muscle cell phenotype conversion and the enhancement of migration and proliferation capacities are key factors that promote the formation of vascular intima.
Mol. Cells 2020;43:749~762
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