Molecules and Cells

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Fig. 8.

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Fig. 8. Inhibition of the JAK2/STAT3 pathway in vivo inhibits neointima formation. (A and B) The activation of JAK2/STAT3 in the ligation group treated with AG490 on at 7 days post-ligation is downregulated. The level of WDR1 decreases significantly. (C-E) Morphometry analysis of CAL and AG490 treatment at 14 days post-ligation. The neointimal area and neointima/media ratio are quantified. The black dotted lines represent the boundary between the arterial tunica media and the neointima; the yellow dotted lines indicate the external elastic lamina (n = 6 per group). Scale bar = 50 μm. *P < 0.05; **P < 0.01.
Mol. Cells 2020;43:749~762
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