Molecules and Cells

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 0219-1032   pISSN 1016-8478

Fig. 6.

Download original image
Fig. 6. Overexpression of Wdr1 rescues impaired cell migration and proliferation in Stat3 knockdown cells. (A and B) HASMCs were treated with Stat3 siRNA and transfected with the pCDNA-WDR1 plasmid (siSTAT3+Wdr1). The transfection efficiency of WDR1 was determined by western blotting. Quantitation of the indicated proteins to the corresponding control is also shown. (C and D) Representative images and averaged data from wound-healing assays in Stat3-siRNA-treated HASMCs show that forced overexpression of Wdr1 rescues the decrease in cell migration caused by Stat3 knockdown (n = 3 per group). Scale bar = 200 μm. (E) CCK-8 assay in HASMCs treated with Stat3 siRNA and transfected with the pCDNA-WDR1 plasmid (n = 3 per group). *P < 0.05; **P < 0.01; ***P < 0.001.
Mol. Cells 2020;43:749~762 https://doi.org/10.14348/molcells.2020.0085
© Mol. Cells