Molecules and Cells

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Fig. 4.

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Fig. 4. Proliferation and migration are significantly inhibited in Wdr1-deficient smooth muscle cells. (A and B) Western blotting analysis and quantification are showing that levels of WDR1 in SMCs from Wdr1 f/f;ERT2Cre are less than those in SMCs from Wdr1 f/f animals. (C and D) After tamoxifen-induced Wdr1 knockout, wound-healing experiments and statistical results showing that SMCs from the Wdr1 f/f group migrated faster than those Wdr1 f/f;ERT2Cre group (n = 3 per group). Scale bar = 200 μm. (E) CCK-8 assays of MASMCs treated with tamoxifen for 2 days (n = 9 per group). (F) Cell-cycle distribution in MASMCs in the absence of Wdr1 (n = 3 per group). Data are expressed as mean ± SEM (n = 3 each). *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.
Mol. Cells 2020;43:749~762 https://doi.org/10.14348/molcells.2020.0085
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