Molecules and Cells

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 0219-1032   pISSN 1016-8478

Fig. 3.

Download original image
Fig. 3. Human RCAN Family members. RCAN genes contain seven exons. RCAN1-1 transcripts (exons 1,5,6,7) produce RCAN1-1L (252 aa) and RCAN1-1S (197 aa) using different start codons in exon 1, while RCAN1-4 transcripts (exons 4,5,6,7) do RCAN1-4 protein (197 aa). RCAN2-1 or RCAN2-2 transcripts (exons 1,3,5,6,7 or exons 2,3,5,6,7) produce RCAN2-3/RCAN2L (243 aa) and RCAN2-4 Transcripts (exons 4,5,6,7) produce RCAN2-4/RCAN2S (197 aa). All RCAN3 transcripts, RCAN3-1, -2, and -3 (exons 1,4,5,6,7; 2,4,6,7; 3,4,5,6,7), produce only one translational product of RCAN3 (241 aa). Green arrows indicate start codons and open red arrowheads point stop codons. Introns containing promoters for the transcripts starting exon 4 are shown in orange. Untranslated regions are in light blue. NCBI database (https://www.ncbi.nlm.nih.gov/gene/) indicates that other transcript variants are detected in various RNA-seq datasets, but their predicted translational products have not confirmed.
Mol. Cells 2020;43:671~685 https://doi.org/10.14348/molcells.2020.0060
© Mol. Cells