Molecules and Cells

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Fig. 3.

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Fig. 3. Schematic abstract showing that RUNX1 enhances leukemia cell engraftment in the vascular niche possibly through modulating E-selectin expressions. Left: E-Selectin keeps AML cells in the bone marrow (BM) niche where chemodrug concentration is lower. Right: RUNX1 inhibition esposes AML cells to higher concenyrationof chemodrug in periferal blood (PB). Modified from the article of Morita et al. (2018) (Blood Adv. 2, 509-515) with original copyright holder's permission.
Mol. Cells 2020;43:198~202
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