Molecules and Cells

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Fig. 1.

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Fig. 1. Auto-regulatory feedback loop of RUNX1-p53-CBFB. RUNX1-inhibition treatment induces p53. Induced p53 directly binds to CBFB promoter and stimulates its transcription and translation, which in turn acts as a platform for the stabilization of RUNX1, thereby creating the compensative RUNX1-p53-CBFB feedback loop. Modified from the article of Morita et al. (2017c) (Sci. Rep. 7, 16604) in accordance with the Creative Commons Attribution 4.0 International (CC BY 4.0) license.
Mol. Cells 2020;43:198~202
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