Molecules and Cells

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Fig. 3.

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Fig. 3. Role of RUNX proteins in the FA pathway. In response to DNA fork stalling at ICLs during the S phase of cell cycle, ATR and PARP1 are activated, which induces RUNX poly(ADP-ribosyl) ation and its interaction with BLM helicase. This leads to efficient recruitment of FANCD2-FANCI onto the ICLs for repair. Data from the article of Tay et al. (2018) (Cell Rep. 24, 1747-1755) in accordance with the Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
Mol. Cells 2020;43:99~106
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