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Fig. 6.

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Fig. 6. (A) The schedule of tumor implantation. (1st) Mice were subcutaneously primed tumor clones expressing IL-15:IL-15Rα (1 × 106 cells/mouse) at day 0 on the left flank. (2nd) One month after the priming, tumor-free mice were subcutaneously challenged with 1 × 106 cells of live wild-type (WT) CT26 cells on the right flank. (3rd) Two months after the boosting step, the tumor-free mice were re-challenged subcutaneously with 1 × 106 cells of live WT CT26 cells on the left flank. (B and C) After the boosting step, the average tumor growth (B) and the survival of mice (C) were monitored daily basis. (D-F) After the re-challenging step with WT CT26, the tumor growth (D) and survival of mice (E) were recorded. On day 18 after the re-challenging, mice with tumor growth were sacrificed, and spleens and tumor masses (F) were photographed. *P < 0.05; **P < 0.01; ***P < 0.001.
Mol. Cells 2019;42:869~883
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