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Fig. 4.

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Fig. 4. (A) The schedule of tumor cell injection for therapeutic effect. Normal mice were implanted with wild-type (WT) CT26 cells (1 × 105 cells/mouse) subcutaneously at the right flank, and injected with MMC-inactivated mock or IL-15:IL-15Rα tumor clones (1 × 106 cells/mouse) at near sites after 3 days (n = 5 for each group). (B and C) Tumor growth (B) and survival (C) of mice were monitored. (D) The schedule of tumor cell injection for vaccination. Mice were subcutaneously vaccinated with MMC-inactivated mock or tumor clones expressing IL-15:IL-15Rα (5 × 105 cells/mouse) at right flank. After two weeks, WT CT26 cells (5 × 105 cells/mouse) were subcutaneously implanted at the left flank. (E and F) Tumor growth (E) and survival (F) of mice were monitored. *P < 0.05.
Mol. Cells 2019;42:869~883 https://doi.org/10.14348/molcells.2019.0188
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