Molecules and Cells

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Fig. 6.

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Fig. 6. ST5 induction by RANKL stimulates activation of Src/Syk signaling. Subsequently, transduction of IP3 by PLC-γ signaling induces calcium oscillation by binding the IP3 receptor on the ER, which increases NFATc1 activation, thereby enhancing osteoclast differentiation by promoting transcription of osteoclast marker genes.
Mol. Cells 2019;42:810~819 https://doi.org/10.14348/molcells.2019.0189
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