Molecules and Cells

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 0219-1032   pISSN 1016-8478

Fig. 1.

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Fig. 1. A total of 15,080 gene probes were plotted to determine STK11 sensitive vs. STK11 specific expression in the CCLE dataset. The sensitivity (i.e., log2 fold-change) was determined based on the gene expression ratio in nine STK11-mutant cell lines compared with 38 STK11 wild-type cell lines. The specificity (i.e., log2 odds ratio) of a gene expression was based on the ratio of the observed odds in STK11-mutant cell lines over the expected odds in all cell lines. Orange circles represent the 71 STK11-specific gene probes with > 2 odds ratio (Fisher’s exact test, P < 0.01) in STK11-mutant cell lines. Blue circles represent the 222 STK11-sensitive gene probes with > 2 fold change (Student’s t-test, P < 0.01) in STK11-mutant cell lines. Filled red circles represent 11 common hits of specific (orange) and sensitive (blue) gene probes.
Mol. Cells 2019;42:804~809
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